昼夜节律对生理系统分子调控的影响

IF 4.2 2区医学 Q1 PHYSIOLOGY Comprehensive Physiology Pub Date : 2021-12-29 DOI:10.1002/cphy.c210011

G Ryan Crislip, Jermaine G Johnston, Lauren G Douma, Hannah M Costello, Alexandria Juffre, Kyla Boyd, Wendy Li, Cheoting C Maugans, Miguel Gutierrez-Monreal, Karyn A Esser, Andrew J Bryant, Andrew C Liu, Michelle L Gumz

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引用次数: 0

摘要

人体内几乎每个系统都有一个固有的细胞昼夜节律钟。昼夜节律钟通过调控基因表达来调节哺乳动物体内的各种平衡过程。生理系统的昼夜节律紊乱与病理生理紊乱有关。在此，我们回顾了目前对已知生理功能昼夜节律的分子机制的理解。本文的重点是对人类的了解，以及对细胞和啮齿动物模型的发现。特别讨论了昼夜节律对代谢、心血管、内分泌、肌肉骨骼、免疫和中枢神经系统的影响。© 2021 美国生理学会。Compr Physiol 11:1-30, 2021.

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Circadian Rhythm Effects on the Molecular Regulation of Physiological Systems.

Nearly every system within the body contains an intrinsic cellular circadian clock. The circadian clock contributes to the regulation of a variety of homeostatic processes in mammals through the regulation of gene expression. Circadian disruption of physiological systems is associated with pathophysiological disorders. Here, we review the current understanding of the molecular mechanisms contributing to the known circadian rhythms in physiological function. This article focuses on what is known in humans, along with discoveries made with cell and rodent models. In particular, the impact of circadian clock components in metabolic, cardiovascular, endocrine, musculoskeletal, immune, and central nervous systems are discussed. © 2021 American Physiological Society. Compr Physiol 11:1-30, 2021.

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来源期刊

Comprehensive Physiology PHYSIOLOGY-

CiteScore

10.50

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Comprehensive Physiology is the most authoritative and comprehensive collection of physiology information ever assembled, and uses the most powerful features of review journals and electronic reference works to cover the latest key developments in the field, through the most authoritative articles on the subjects covered. This makes Comprehensive Physiology a valued reference work on the evolving science of physiology for both researchers and clinicians. It also provides a useful teaching tool for instructors and an informative resource for medical students and other students in the life and health sciences.