维生素D在癌症中的代谢:维生素D代谢阻断疗法的潜在可行性。

IF 1.2 4区医学 Q3 PATHOLOGY Medical Molecular Morphology Pub Date : 2023-06-01 DOI:10.1007/s00795-023-00348-x

Sakura Kamiya, Yuna Nakamori, Akira Takasawa, Kumi Takasawa, Daisuke Kyuno, Yusuke Ono, Kazufumi Magara, Makoto Osanai

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摘要

在这篇综述中，我们讨论了维生素D代谢酶CYP24A1作为多种肿瘤包括乳腺癌、结肠直肠癌和前列腺肿瘤的治疗靶点的可能性。鉴于维生素D的多效性细胞活性，其缺乏会损害其在靶细胞中的生理功能，并导致包括癌症在内的各种病理。此外，积累的数据表明，CYP24A1的表达升高通过降低维生素D代谢物的生物利用度来促进各种癌症亚型的癌变。因此，我们提出维生素D代谢阻断治疗多种表达构成型CYP24A1的人类恶性肿瘤的潜在可行性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Vitamin D metabolism in cancer: potential feasibility of vitamin D metabolism blocking therapy.

In this review, we discuss the possibility of the vitamin D metabolizing enzyme CYP24A1 being a therapeutic target for various tumors including breast, colorectal and prostate tumors. Given the pleiotropic cellular activity of vitamin D, its deficiency impairs its physiological function in target cells and results in various pathologies including cancer. In addition, accumulated data have shown that elevated expression of CYP24A1 promotes carcinogenesis in various cancer subtypes by decreasing the bioavailability of vitamin D metabolites. Thus, we propose the potential feasibility of vitamin D metabolism-blocking therapy in various types of human malignancies that express constitutive CYP24A1.

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来源期刊

Medical Molecular Morphology 医学-病理学

CiteScore

2.90

自引率

5.60%

发文量

审稿时长

>12 weeks

期刊介绍： Medical Molecular Morphology is an international forum for researchers in both basic and clinical medicine to present and discuss new research on the structural mechanisms and the processes of health and disease at the molecular level. The structures of molecules, organelles, cells, tissues, and organs determine their normal function. Disease is thus best understood in terms of structural changes in these different levels of biological organization, especially in molecules and molecular interactions as well as the cellular localization of chemical components. Medical Molecular Morphology welcomes articles on basic or clinical research in the fields of cell biology, molecular biology, and medical, veterinary, and dental sciences using techniques for structural research such as electron microscopy, confocal laser scanning microscopy, enzyme histochemistry, immunohistochemistry, radioautography, X-ray microanalysis, and in situ hybridization. Manuscripts submitted for publication must contain a statement to the effect that all human studies have been reviewed by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in an appropriate version of the 1964 Declaration of Helsinki. It should also be stated clearly in the text that all persons gave their informed consent prior to their inclusion in the study. Details that might disclose the identity of the subjects under study should be omitted.