双相抑郁症患者肠道菌群及其与炎症的关系:一项横断面研究。

IF 3.6 3区 医学 Q1 PSYCHIATRY Annals of General Psychiatry Pub Date : 2023-05-19 DOI:10.1186/s12991-023-00453-2
Tingting Huang, Yushan Shang, Chunxiao Dai, Qixiu Zhang, Shaohua Hu, Jian Xie
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引用次数: 1

摘要

背景:探讨抑郁症双相情感障碍(BD)患者肠道菌群特征及肠道菌群与炎症标志物的关系。方法:72例抑郁症双相障碍患者和16例健康对照(hc)。从每位受试者身上抽取血液和粪便样本。在16s -核糖体RNA基因测序的帮助下,研究了每个参与者的肠道微生物群特征。然后利用相关性分析来评估肠道菌群与临床参数之间的关系。结果:我们发现,与hc患者相比,BD患者的肠道微生物群的分类组成存在显著差异,但其多样性不存在显著差异。我们发现,杆菌属、乳酸杆菌属和细微杆菌属在BD患者中的丰度高于hc患者,而Dorea属在hc患者中丰度更高。此外,相关分析显示,BD患者的细菌属丰度与抑郁症的严重程度和炎症标志物密切相关。结论:根据这些结果,抑郁症BD患者的肠道菌群特征发生了变化,这可能与抑郁症的严重程度和炎症途径有关。
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Gut microbiota and its relation to inflammation in patients with bipolar depression: a cross-sectional study.

Background: To explore the gut microbiota characteristics in depressed patients with bipolar disorder (BD) as well as the connection between the gut microbiota and inflammatory markers.

Methods: Totally 72 depressed BD patients and 16 healthy controls (HCs) were enrolled in the study. Blood and feces samples were taken from each subject. With the help of 16S-ribosomal RNA gene sequencing, the characteristics of the gut microbiota in each participant were examined. Correlation analysis was then utilized to assess the relationship between the gut microbiota and clinical parameters.

Results: We found the taxonomic composition of the gut microbiota, but not its diversity, was significantly different in BD patients compared to HCs. We found the abundance of Bacilli, Lactobacillales and genus Veillonella were higher in BD patients than in HCs, while genus Dorea was more abundant in HCs. Additionally, correlation analysis showed that the bacterial genera' abundance in BD patients was strongly correlated with the severity of depression and inflammatory markers.

Conclusions: According to these results, the gut microbiota characteristics were changed in depressed BD patients, which may have been associated with the severity of depression and the inflammatory pathways.

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来源期刊
CiteScore
6.60
自引率
2.70%
发文量
43
审稿时长
>12 weeks
期刊介绍: Annals of General Psychiatry considers manuscripts on all aspects of psychiatry, including neuroscience and psychological medicine. Both basic and clinical neuroscience contributions are encouraged. Annals of General Psychiatry emphasizes a biopsychosocial approach to illness and health and strongly supports and follows the principles of evidence-based medicine. As an open access journal, Annals of General Psychiatry facilitates the worldwide distribution of high quality psychiatry and mental health research. The journal considers submissions on a wide range of topics including, but not limited to, psychopharmacology, forensic psychiatry, psychotic disorders, psychiatric genetics, and mood and anxiety disorders.
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