左旋肉碱通过抗氧化和抗炎途径对X射线致子宫损伤的保护作用。

IF 2.1 4区 医学 Q2 BIOLOGY International Journal of Radiation Biology Pub Date : 2023-01-01 DOI:10.1080/09553002.2023.2158247
Serkan Karacetin, Meryem Akpolat, Zehra Safi Oz, Ayse Ceylan Hamamcioglu
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引用次数: 0

摘要

目的:电离辐射可引起氧化应激引起的组织损伤,降低生殖发生率。本研究旨在探讨左旋肉碱对辐射性子宫损伤的影响。材料与方法:30只Wistar白化大鼠分为5组。对照组腹腔注射生理盐水。辐射1组和辐射2组采用单剂量8.3 Gy全身x射线照射。各组分别于照射后第6小时和第4天处死。辐射-1 +左旋肉碱组和辐射-2 +左旋肉碱组在相同剂量照射的基础上,每日给予200 mg/kg左旋肉碱剂量。在照射前1天和照射后4天分别应用左旋肉碱。结果:左旋肉碱治疗部分阻断了深部腺体的耗竭和辐射诱导的腺上皮和子宫内膜表面变平。IL-1β、IL-6、TNF-α等促炎因子在辐照小鼠子宫组织中显著表达。放疗组子宫组织中NFκB、PARP-1的表达均较左旋肉碱处理组和对照组显著升高。结果表明,辐射组小鼠氧化应激指数升高,左旋肉碱组小鼠氧化应激指数降低。结论:左旋肉碱对辐射致子宫损伤有积极作用。左旋肉碱在盆腔癌放疗期间可能是一种潜在的安全的放射性保护剂,前提是肿瘤不像正常组织那样受到辐射损伤的保护。然而,前瞻性临床试验研究是必要的,以了解其疗效。
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Protective effects of L-carnitine on X irradiation-induced uterus injury via antioxidant and anti-inflammatory pathways.
Abstract Purpose Ionizing radiation causes oxidative stress induced tissue damage as well as a decline in reproduction incidence. The purpose of our study was to evaluate the effects of L-carnitine on radiation-induced uterine injury. Materials and methods Thirty Wistar albino rats were classified into five groups. Physiological saline was administered intraperitoneally to the control group. A single dose of 8.3 Gy whole body X-irradiation was applied to the radiation-1 and radiation-2 groups. These groups were sacrificed on the 6th hour and 4th day, respectively, after irradiation. Radiation-1 + L-carnitine and radiation-2 + L-carnitine groups received a daily dose of 200 mg/kg L-carnitine in addition to the same dose of irradiation. L-carnitine was also applied one day before and four days after irradiation. Results L-carnitine therapy partially blocks the depletion of the deep glands and radiation-induced flattening of the glandular epithelium and endometrial surface. Proinflammatory cytokines such as IL-1β, IL-6 and TNF-α were found to be significantly expressed in the uterus tissue of irradiated mice. In the radiation groups, NFκB and PARP-1 expressions in uterine tissue was significantly increased compared to L-carnitine treated and the control groups. It was observed that the oxidative stress index increased in the radiation groups, but decreased in the L-carnitine applied groups. Conclusions Our findings showed that L-carnitine has a positive effect on radiation-induced uterine damage. L-carnitine may be a potential safe radio protective agent during radiotherapy for pelvic cancer provided the tumor is not protected from radiation damage to the same extent as the normal tissue is. However, prospective clinical trial studies are necessary to understand its efficacy.
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来源期刊
CiteScore
5.00
自引率
11.50%
发文量
142
审稿时长
3 months
期刊介绍: The International Journal of Radiation Biology publishes original papers, reviews, current topic articles, technical notes/reports, and meeting reports on the effects of ionizing, UV and visible radiation, accelerated particles, electromagnetic fields, ultrasound, heat and related modalities. The focus is on the biological effects of such radiations: from radiation chemistry to the spectrum of responses of living organisms and underlying mechanisms, including genetic abnormalities, repair phenomena, cell death, dose modifying agents and tissue responses. Application of basic studies to medical uses of radiation extends the coverage to practical problems such as physical and chemical adjuvants which improve the effectiveness of radiation in cancer therapy. Assessment of the hazards of low doses of radiation is also considered.
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