脂质I和II及其缩短类似物的合成策略和策略:细菌细胞壁生物合成的功能构建块。

IF 12.7 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY ACS Central Science Pub Date : 2023-11-15 DOI:10.1039/d3np00018d

Christina Braun , Lukas Martin Wingen , Dirk Menche

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引用次数: 0

摘要

涵盖:截至2022年的文献。本研究讨论了合成脂质II的各种合成策略，脂质II是关键的细菌细胞壁前体。详细地，它检查不同的溶液相方法，回顾各种固相序列，并评估酶的风险。讨论了这些策略的基本原理、范围、限制和前景。重点是针对真正的肽聚糖化合物的战术和策略，以及其缩短侧链的类似物，它们越来越被认为是更有益的替代品，具有更有利的物理化学性质。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Strategies and tactics for the synthesis of lipid I and II and shortened analogues: functional building blocks of bacterial cell wall biosynthesis

Covering: the literature up to 2022

This study discusses various synthetic strategies for the synthesis of lipid II, the pivotal bacterial cell wall precursor. In detail, it examines different solution phase approaches, reviews various solid phase sequences, and evaluates enzymatic ventures. The underlying rationale, scope, limitations, and perspectives of these strategies are discussed. The focus is on the tactics and strategies towards the authentic peptidoglycan compound, as well as analogues thereof with shortened side chains, which are increasingly recognized as more beneficial surrogates with more favorable physicochemical properties.

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来源期刊

ACS Central Science Chemical Engineering-General Chemical Engineering

CiteScore

25.50

自引率

0.50%

发文量

194

审稿时长

10 weeks

期刊介绍： ACS Central Science publishes significant primary reports on research in chemistry and allied fields where chemical approaches are pivotal. As the first fully open-access journal by the American Chemical Society, it covers compelling and important contributions to the broad chemistry and scientific community. "Central science," a term popularized nearly 40 years ago, emphasizes chemistry's central role in connecting physical and life sciences, and fundamental sciences with applied disciplines like medicine and engineering. The journal focuses on exceptional quality articles, addressing advances in fundamental chemistry and interdisciplinary research.