黄斑部一氧化氮合成酶 1 Beta 突变在调节肾小管反馈中的作用

IF 4.2 2区 医学 Q1 PHYSIOLOGY Comprehensive Physiology Pub Date : 2023-01-30 DOI:10.1002/cphy.c210043
Ruisheng Liu, Luis A Juncos, Yan Lu, Jin Wei, Jie Zhang, Lei Wang, En Y Lai, Mattias Carlstrom, A Erik G Persson
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引用次数: 0

摘要

肾脏电解质和水排泄异常可能导致不适当的盐和水潴留,从而促进高血压以及酸碱和电解质紊乱的发生和维持。肾脏调节肾血流动力学和电解质排泄的一个关键机制是肾小管肾小球反馈(TGF),这是肾小管和动脉之间的一种肾内负反馈。肾小管肾小球反馈(TGF)是肾小管和动脉血管之间的一种肾内负反馈。增加的 NaCl 会激活肾小管黄斑细胞腔内的 Na-K-2Cl 共转运体(NKCC2),从而激活多个细胞内过程,随后产生旁分泌信号,最终导致传入动脉收缩和单肾小球滤过率的强直性抑制。神经元一氧化氮(NOS1)在黄斑中高度表达。NOS1β 是主要的剪接变体,占黄斑部产生的 NO 的大部分,可抑制 TGF 反应。黄斑区 NOS1β 介导的对 TGF 反应的调节在控制钠排泄、血容量和电解质止血以及血压方面发挥着重要作用。在本文中,我们描述了在生理和病理条件下调节黄斑区源性 NO 的机制及其对 TGF 反应的影响。© 2023 美国生理学会。Compr Physiol 13:4215-4229, 2023.
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The Role of Macula Densa Nitric Oxide Synthase 1 Beta Splice Variant in Modulating Tubuloglomerular Feedback.

Abnormalities in renal electrolyte and water excretion may result in inappropriate salt and water retention, which facilitates the development and maintenance of hypertension, as well as acid-base and electrolyte disorders. A key mechanism by which the kidney regulates renal hemodynamics and electrolyte excretion is via tubuloglomerular feedback (TGF), an intrarenal negative feedback between tubules and arterioles. TGF is initiated by an increase of NaCl delivery at the macula densa cells. The increased NaCl activates luminal Na-K-2Cl cotransporter (NKCC2) of the macula densa cells, which leads to activation of several intracellular processes followed by the production of paracrine signals that ultimately result in a constriction of the afferent arteriole and a tonic inhibition of single nephron glomerular filtration rate. Neuronal nitric oxide (NOS1) is highly expressed in the macula densa. NOS1β is the major splice variant and accounts for most of NO generation by the macula densa, which inhibits TGF response. Macula densa NOS1β-mediated modulation of TGF responses plays an essential role in control of sodium excretion, volume and electrolyte hemostasis, and blood pressure. In this article, we describe the mechanisms that regulate macula densa-derived NO and their effect on TGF response in physiologic and pathologic conditions. © 2023 American Physiological Society. Compr Physiol 13:4215-4229, 2023.

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来源期刊
CiteScore
10.50
自引率
0.00%
发文量
38
审稿时长
6-12 weeks
期刊介绍: Comprehensive Physiology is the most authoritative and comprehensive collection of physiology information ever assembled, and uses the most powerful features of review journals and electronic reference works to cover the latest key developments in the field, through the most authoritative articles on the subjects covered. This makes Comprehensive Physiology a valued reference work on the evolving science of physiology for both researchers and clinicians. It also provides a useful teaching tool for instructors and an informative resource for medical students and other students in the life and health sciences.
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