2019冠状病毒病妊娠期感染及不良妊娠结局:系统综述和荟萃分析

IF 2 Q2 OBSTETRICS & GYNECOLOGY Obstetrics and Gynecology Science Pub Date : 2023-07-01 Epub Date: 2023-05-17 DOI:10.5468/ogs.22323
Yeonsong Jeong, Min-A Kim
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引用次数: 4

摘要

2019年12月开始的2019冠状病毒病(COVID-19)疫情迅速发展成为全球卫生问题。孕妇易患呼吸道感染,并可能出现不良后果。本系统综述和荟萃分析比较了COVID-19疾病状态下的妊娠结局。在MEDLINE、EMBASE和Cochrane图书馆数据库中检索2019年12月1日至2022年10月19日之间发表的相关文章。主要纳入标准是任何基于人群的、横断面的、队列的或病例对照的研究,这些研究评估了有或没有实验室确诊的COVID-19妇女的妊娠结局。纳入69项研究,包括1,606,543名孕妇(诊断为COVID-19的39,716名[2.4%])。covid -19感染孕妇早产风险较高(优势比[OR], 1.59;95%可信区间[CI], 1.42-1.78),先兆子痫(OR, 1.41;95% CI, 1.30-1.53),低出生体重(OR, 1.52;95% CI, 1.30-1.79),剖宫产(OR, 1.20;95% CI, 1.10-1.30),死产(OR, 1.71;95% CI, 1.39-2.10),胎儿窘迫(OR, 2.49;95% CI, 1.54-4.03),新生儿重症监护病房入院(OR, 2.33;95% CI, 1.72-3.16),围产期死亡率(OR, 1.96;95% CI, 1.15-3.34)和孕产妇死亡率(OR, 6.15;95% ci, 3.74-10.10)。总流产、早产、胎膜早破、产后出血、胆汁淤积、绒毛膜羊膜炎的感染情况差异无统计学意义。本综述表明,妊娠期感染COVID-19可导致不良妊娠结局。这些信息可以帮助研究人员和临床医生为新发现的呼吸道病毒引起的另一场大流行做准备。这项研究的结果可能有助于基于证据的咨询,并帮助临床医生管理感染COVID-19的孕妇。
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The coronavirus disease 2019 infection in pregnancy and adverse pregnancy outcomes: a systematic review and meta-analysis.

The coronavirus disease 2019 (COVID-19) outbreak which started in December 2019 rapidly developed into a global health concern. Pregnant women are susceptible to respiratory infections and can experience adverse outcomes. This systematic review and meta-analysis compared pregnancy outcomes according to COVID-19 disease status. The MEDLINE, EMBASE, and Cochrane Library databases were searched for relevant articles published between December 1, 2019, and October 19, 2022. Main inclusion criterion was any population-based, cross-sectional, cohort, or case-control study that assessed pregnancy outcomes in women with or without laboratory-confirmed COVID-19. Sixty-nine studies including 1,606,543 pregnant women (39,716 [2.4%] diagnosed with COVID-19) were retrieved. COVID-19-infected pregnant women had a higher risk of preterm birth (odds ratio [OR], 1.59; 95% confidence interval [CI], 1.42-1.78), preeclampsia (OR, 1.41; 95% CI, 1.30-1.53), low birth weight (OR, 1.52; 95% CI, 1.30-1.79), cesarean delivery (OR, 1.20; 95% CI, 1.10-1.30), stillbirth (OR, 1.71; 95% CI, 1.39-2.10), fetal distress (OR, 2.49; 95% CI, 1.54-4.03), neonatal intensive care unit admission (OR, 2.33; 95% CI, 1.72-3.16), perinatal mortality (OR, 1.96; 95% CI, 1.15-3.34), and maternal mortality (OR, 6.15; 95% CI, 3.74-10.10). There were no significant differences in total miscarriage, preterm premature rupture of membranes, postpartum hemorrhage, cholestasis, or chorioamnionitis according to infection. This review demonstrates that COVID-19 infection during pregnancy can lead to adverse pregnancy outcomes. This information could aid researchers and clinicians in preparing for another pandemic caused by newly discovered respiratory viruses. The findings of this study may assist with evidence-based counseling and help clinicians manage pregnant women with COVID-19.

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来源期刊
Obstetrics and Gynecology Science
Obstetrics and Gynecology Science Medicine-Obstetrics and Gynecology
CiteScore
3.80
自引率
15.80%
发文量
58
审稿时长
16 weeks
期刊介绍: Obstetrics & Gynecology Science (NLM title: Obstet Gynecol Sci) is an international peer-review journal that published basic, translational, clinical research, and clinical practice guideline to promote women’s health and prevent obstetric and gynecologic disorders. The journal has an international editorial board and is published in English on the 15th day of every other month. Submitted manuscripts should not contain previously published material and should not be under consideration for publication elsewhere. The journal has been publishing articles since 1958. The aim of the journal is to publish original articles, reviews, case reports, short communications, letters to the editor, and video articles that have the potential to change the practices in women''s health care. The journal’s main focus is the diagnosis, treatment, prediction, and prevention of obstetric and gynecologic disorders. Because the life expectancy of Korean and Asian women is increasing, the journal''s editors are particularly interested in the health of elderly women in these population groups. The journal also publishes articles about reproductive biology, stem cell research, and artificial intelligence research for women; additionally, it provides insights into the physiology and mechanisms of obstetric and gynecologic diseases.
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