{"title":"Acanthus ilicifoliusL.的两种新木脂素苷及其 NO 抑制和细胞毒活性。","authors":"","doi":"10.1080/14786419.2023.2218009","DOIUrl":null,"url":null,"abstract":"<div><div>A phytochemical investigation of the methanolic extract of aerial parts of the <em>Acanthus ilicifolius</em> led to the isolation of two new lignan glycosides, acaniliciosides A and B (<strong>1</strong> and <strong>2</strong>), together with ten known compounds (<strong>3</strong>-<strong>12</strong>). The structures of isolated compounds were elucidated based on HR-ESI-MS, 1D and 2D NMR spectroscopic data. The absolute configurations of two new compounds were established by CD spectra. With the exception of compound <strong>12</strong>, other compounds inhibited NO production in LPS activated RAW264.7 cells with IC<sub>50</sub> values of 2.14-28.18 µM, as potent as that of the positive control of <em>N</em><sup>G</sup>-monomethyl-L-arginine acetate (L-NMMA, IC<sub>50</sub> of 32.50 µM). In addition, compounds <strong>5</strong>-<strong>8</strong> showed cytotoxic effects against SK-LU-1 and HepG2 cell lines with the IC<sub>50</sub> values ranging from 16.48 to 76.40 μM compared to the positive control (ellipticine) with the IC<sub>50</sub> values ranging from 1.23 to 1.46 μM.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9000,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Two new lignan glycosides from Acanthus ilicifoliusL. with their NO inhibition and cytotoxic activity\",\"authors\":\"\",\"doi\":\"10.1080/14786419.2023.2218009\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>A phytochemical investigation of the methanolic extract of aerial parts of the <em>Acanthus ilicifolius</em> led to the isolation of two new lignan glycosides, acaniliciosides A and B (<strong>1</strong> and <strong>2</strong>), together with ten known compounds (<strong>3</strong>-<strong>12</strong>). The structures of isolated compounds were elucidated based on HR-ESI-MS, 1D and 2D NMR spectroscopic data. The absolute configurations of two new compounds were established by CD spectra. With the exception of compound <strong>12</strong>, other compounds inhibited NO production in LPS activated RAW264.7 cells with IC<sub>50</sub> values of 2.14-28.18 µM, as potent as that of the positive control of <em>N</em><sup>G</sup>-monomethyl-L-arginine acetate (L-NMMA, IC<sub>50</sub> of 32.50 µM). In addition, compounds <strong>5</strong>-<strong>8</strong> showed cytotoxic effects against SK-LU-1 and HepG2 cell lines with the IC<sub>50</sub> values ranging from 16.48 to 76.40 μM compared to the positive control (ellipticine) with the IC<sub>50</sub> values ranging from 1.23 to 1.46 μM.</div></div>\",\"PeriodicalId\":18990,\"journal\":{\"name\":\"Natural Product Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2024-09-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Natural Product Research\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S1478641923017163\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1478641923017163","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
Two new lignan glycosides from Acanthus ilicifoliusL. with their NO inhibition and cytotoxic activity
A phytochemical investigation of the methanolic extract of aerial parts of the Acanthus ilicifolius led to the isolation of two new lignan glycosides, acaniliciosides A and B (1 and 2), together with ten known compounds (3-12). The structures of isolated compounds were elucidated based on HR-ESI-MS, 1D and 2D NMR spectroscopic data. The absolute configurations of two new compounds were established by CD spectra. With the exception of compound 12, other compounds inhibited NO production in LPS activated RAW264.7 cells with IC50 values of 2.14-28.18 µM, as potent as that of the positive control of NG-monomethyl-L-arginine acetate (L-NMMA, IC50 of 32.50 µM). In addition, compounds 5-8 showed cytotoxic effects against SK-LU-1 and HepG2 cell lines with the IC50 values ranging from 16.48 to 76.40 μM compared to the positive control (ellipticine) with the IC50 values ranging from 1.23 to 1.46 μM.
期刊介绍:
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.