循环多不饱和脂肪酸,压力疼痛阈值,和伤害性疼痛状况

Anne E. Sanders , E. Diane Weatherspoon , Brandie M. Ehrmann , Paul S. Soma , Saame R. Shaikh , John S. Preisser , Richard Ohrbach , Roger B. Fillingim , Gary D. Slade
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引用次数: 6

摘要

目的探讨多不饱和脂肪酸(PUFAs)在疼痛调节中的作用。这项研究试图确定在红细胞中发现的游离PUFAs是否也在伤害性加工中发挥作用。我们研究了循环PUFAs与有害机械刺激的伤害阈值之间的关系。我们还确定了伤害阈是否与伤害性疼痛有关。方法:本横断面研究使用605名慢性重叠性疼痛的opopera -2研究中储存的红细胞和数据。在opopera -2中,成年人完成了定量感觉测试,其中压力测量法测量了六个解剖部位的深层肌肉组织敏感性。标准化方案根据存在或不存在五种害性疼痛情况对成人进行分类:颞下颌紊乱、头痛、腰痛、肠易激综合征和纤维肌痛。液相色谱串联质谱法定量红细胞PUFAs。我们进行了三组分析。首先,多变量线性回归模型评估了n-6/n-3 PUFA比率与重叠伤害性疼痛状况的数量之间的关系。其次,36个多变量线性回归模型评估了pufa与6个解剖部位伤害阈值之间的协变量调整关联。第三,一系列30个多变量线性回归模型评估了6个解剖部位的伤害阈值与5种疼痛状况之间的协变量调整关联。结果在多元线性回归中,n-6/n-3 PUFA比值每增加一个单位与更多的疼痛状况相关(β = 0.30, 95%置信区间:0.07,0.53,p = 0.012)。Omega-6亚油酸和花生四烯酸分别与3个和5个解剖部位的较低伤害性阈值负相关。相比之下,omega-3 α -亚麻酸、二十碳五烯酸、二十二碳六烯酸和n-6/n-3 PUFA比例与任何部位的伤害阈值无关。在所有解剖部位,疼痛病例的伤害阈值明显低于非病例对照。结论n-6/n-3 PUFA比值越高,疼痛状况越严重。Omega-6 PUFAs可能促进伤害性加工的普遍上调。
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Circulating polyunsaturated fatty acids, pressure pain thresholds, and nociplastic pain conditions

Objective

Polyunsaturated fatty acids (PUFAs) play a role in pain regulation. This study sought to determine whether free PUFAs found in red blood cells also play a role in nociceptive processing. We examined associations between circulating PUFAs and nociceptive thresholds to noxious mechanical stimuli. We also determined whether nociceptive thresholds were associated with nociplastic pain conditions.

Methods

This cross-sectional study used stored red bloods cells and data from 605 adult participants in the OPPERA-2 study of chronic overlapping pain conditions. In OPPERA-2 adults completed quantitative sensory testing in which pressure algometry measured deep muscular tissue sensitivity at six anatomical sites. Standardized protocols classified adults for presence or absence of five nociplastic pain conditions: temporomandibular disorder, headache, low back pain, irritable bowel syndrome and fibromyalgia. Liquid chromatography tandem mass spectroscopy quantified erythrocyte PUFAs. We conducted three sets of analyses. First, a multivariable linear regression model assessed the association between n-6/n-3 PUFA ratio and the number of overlapping nociplastic pain conditions. Second, a series of 36 multivariable linear regression models assessed covariate-adjusted associations between PUFAs and nociceptive thresholds at each of six anatomical sites. Third, a series of 30 multivariable linear regression models assessed covariate-adjusted associations between nociceptive thresholds at six anatomical sites and each of five pain conditions.

Results

In multiple linear regression, each unit increase in n-6/n-3 PUFA ratio was associated with more pain conditions (β = 0.30, 95% confidence limits: 0.07, 0.53, p = 0.012). Omega-6 linoleic acid and arachidonic acid were negatively associated with lower nociceptive thresholds at three and at five, respectively, anatomical sites. In contrast, omega-3 alpha-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid and the n-6/n-3 PUFA ratio were not associated with nociceptive thresholds at any site. Pain cases had significantly lower nociceptive thresholds than non-case controls at all anatomical sites.

Conclusion

A higher n-6/n-3 PUFA ratio was associated with more pain conditions. Omega-6 PUFAs may promote a generalized upregulation of nociceptive processing.

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来源期刊
Prostaglandins, leukotrienes, and essential fatty acids
Prostaglandins, leukotrienes, and essential fatty acids Clinical Biochemistry, Endocrinology, Diabetes and Metabolism
CiteScore
5.30
自引率
0.00%
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0
审稿时长
64 days
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