自身免疫性肝炎患者长期硫唑嘌呤治疗后出现可逆性颅内病变1例报告。

IF 1.2 Q4 GASTROENTEROLOGY & HEPATOLOGY Hepatology Forum Pub Date : 2023-03-01 DOI:10.14744/hf.2023.2023.0006
Ali Hasan Aysha, Elif Bulut, Onur Keskin
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引用次数: 0

摘要

本研究报告一例患有自身免疫性肝炎(AIH)的67岁女性,出现平衡和行走困难。临床和影像学检查更多提示AIH合并淋巴细胞增生性疾病。为了确定潜在的疑似淋巴增生性疾病,进行了一系列脑部扫描,显示多发性脑病变。这是一个引人注目的病例,在AIH患者中发现了多发增强对比剂脑病变,并在停用硫唑嘌呤后得到解决。硫唑嘌呤的许多副作用是全世界公认的;然而,据我们所知,一篇关于硫唑嘌呤诱导疑似恶性肿瘤的文章从未报道过。
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A case report of reversible intracranial lesions after long-term Azathioprine therapy in an autoimmune hepatitis patient.

This study is written to report a case of 67-year-old female with known autoimmune hepatitis (AIH) who developed balance and walking difficulties. Clinical and imaging investigations were more suggestive of AIH suffering from lymphoproliferative disease. To identify the underlying suspected lymphoproliferative disease, series of brain scans were performed, which showed multiple brain lesions. This is a report on a striking case of multiple contrast enhanced brain lesions discovered in an AIH patient that was resolved upon withdrawal of azathioprine. Many side effects of azathioprine are acknowledged around the world; however, to the very best of our knowledge, an article on azathioprine inducing suspected malignancy was never reported.

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1.90
自引率
12.50%
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