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Safety analysis of different ıntensities of elf-pemf in terms of apoptotic, inflammatory, and transcription factor NF-Κb expression levels in rat liver. 不同浓度的 elf-pemf 对大鼠肝脏中细胞凋亡、炎症和转录因子 NF-Κb 表达水平的安全性分析。
IF 1.2 Q4 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-11-09 eCollection Date: 2024-01-01 DOI: 10.14744/hf.2024.2024.0005
Yasin Gokce, Ugur Seker, Merve Pekince Ozoner

Background and aim: The purpose of this research was to ascertain how exposure to extremely low-frequency pulsed electromagnetic fields (ELF-PEMFs) at varying intensities affects apoptosis-related protein expression levels and liver morphology in rats.

Materials and methods: In this experimental study, 40 Wistar albino rats were randomly divided into 4 groups, with 10 animals in each group: Control, Sham, 1 milli Tesla (1mT), and 5 mT groups. The control group did not expose any application during the experiment. Animals in the sham group were placed into the closed ELF-PEMF exposure environment, but the device was kept closed. The rats in the 1mT and 5mT groups were placed into a closed ELF-PEMF exposure environment, and the magnetic field application was applied 5 days a week for 4 hours a day for 8 weeks. At the end of the study, the animals were sacrificed, and their liver tissues were examined morphologically, and the expression levels of proteins related to apoptosis and inflammation in these tissues were analyzed.

Results: Our results indicated that ELF-PEMFs did not lead to any exact morphological alterations in the groups. Tissue apoptotic Bax and Caspase 3 expression levels in the 1mT and 5mT groups were similar (p>0.05) to the control group. Additionally, pro-inflammatory TNF-α and transcription factor NF-κB in the 1mT and 5mT groups were similar (p>0.05) to each other and the control group.

Conclusion: It is feasible to conclude that neither the administration nor the exposure design of this study is changing the immunoexpression of apoptosis-regulating protein expression levels or liver morphology exposed to ELF-PEMF in rats.

背景和目的:本研究旨在确定暴露于不同强度的极低频脉冲电磁场(ELF-PEMFs)如何影响大鼠体内与细胞凋亡相关的蛋白质表达水平和肝脏形态:本实验研究将 40 只 Wistar 白化大鼠随机分为 4 组,每组 10 只:对照组、Sham 组、1 毫特斯拉(1mT)组和 5 mT 组。对照组在实验过程中不接触任何应用。假组的动物被放入封闭的 ELF-PEMF 暴露环境中,但装置保持封闭。1mT 和 5mT 组的大鼠被置于封闭的 ELF-PEMF 暴露环境中,每周 5 天、每天 4 小时施加磁场,持续 8 周。研究结束后,动物被处死,对其肝组织进行形态学检查,并分析这些组织中与细胞凋亡和炎症有关的蛋白质的表达水平:结果:我们的研究结果表明,ELF-PEMFs 并未导致各组动物发生任何确切的形态学改变。1mT组和5mT组组织凋亡Bax和Caspase 3的表达水平与对照组相似(P>0.05)。此外,1mT 组和 5mT 组的促炎因子 TNF-α 和转录因子 NF-κB 与对照组相似(P>0.05):本研究的给药和暴露设计均未改变大鼠暴露于 ELF-PEMF 后凋亡调节蛋白的免疫表达水平或肝脏形态,这一结论是可行的。
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引用次数: 0
An alternative method in the diagnosis of intrabiliary lesions: Percutaneous endobiliary brush biopsy. 诊断胆道内病变的另一种方法:经皮胆管刷状活检。
IF 1.2 Q4 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-10-09 eCollection Date: 2024-01-01 DOI: 10.14744/hf.2023.2023.0073
Mustafa Ozdemir, Tunahan Dertli, Omer Faruk Sevinc, Onur Taydas, Gurkan Danisan, Omer Faruk Ates, Mehmet Halil Ozturk

Background and aim: Biliary strictures can occur as a result of various benign or malignant processes. The aim of this study is to evaluate the effectiveness and reliability of percutaneous endobiliary brush biopsy in the diagnosis of intrabiliary lesions.

Materials and methods: This retrospective, single-center study was conducted between January 2022 and April 2023, involving a total of 16 patients. Of the patients, 10 were male (62.5%), and 6 were female (37.5%). The average age of the patients was 68.1±8. All patients underwent the procedure using an endobiliary biopsy brush under ultrasound and fluoroscopic guidance.

Results: Technical success was achieved in all patients (100%). Cell detection was not observed in biopsy samples from 2 patients (12.5%), resulting in a diagnostic success rate of 87.5%. Access was made to the right biliary system in 14 patients (87.5%) and to the left biliary system in 2 patients (12.5%). Biopsy locations included the common bile duct in 12 patients (75%), hepatic hilum in 2 patients (12.5%), and bilioenteric anastomosis line in 2 patients (12.5%). The mean fluoroscopy time was 16.2±7.1 minutes. The average radiation dose was 660±370 mSv. Pathological diagnosis revealed malignancy in 8 patients (50%) and benign findings in 6 patients (37.5%). Liver abscess requiring drainage developed in 2 patients (12.5%).

Conclusion: Percutaneous endobiliary brush biopsy performed under imaging guidance is an effective and reliable method for the diagnosis of biliary lesions.

背景和目的:各种良性或恶性过程均可导致胆道狭窄。本研究旨在评估经皮胆道内刷状活检术在诊断胆道内病变中的有效性和可靠性:这项回顾性单中心研究于 2022 年 1 月至 2023 年 4 月间进行,共涉及 16 名患者。其中男性 10 例(62.5%),女性 6 例(37.5%)。所有患者均在超声和透视引导下使用胆道内活检刷进行了手术:结果:所有患者都取得了技术成功(100%)。2例患者(12.5%)的活检样本未发现细胞,诊断成功率为87.5%。14名患者(87.5%)的活检进入了右胆管系统,2名患者(12.5%)的活检进入了左胆管系统。活检位置包括 12 名患者(75%)的胆总管、2 名患者(12.5%)的肝门和 2 名患者(12.5%)的胆肠吻合线。平均透视时间为(16.2±7.1)分钟。平均辐射剂量为 660±370 mSv。病理诊断显示,8 名患者(50%)为恶性,6 名患者(37.5%)为良性。2例患者(12.5%)出现需要引流的肝脓肿:结论:在影像学引导下进行经皮胆管刷状活检是诊断胆道病变的一种有效而可靠的方法。
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引用次数: 0
D-dimer is a prognostic marker for 1-year mortality in patients with chronic liver failure and hepatic encephalopathy. D 二聚体是慢性肝衰竭和肝性脑病患者 1 年死亡率的预后指标。
IF 1.2 Q4 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-09-11 eCollection Date: 2024-01-01 DOI: 10.14744/hf.2023.2023.0065
Yi-Shan He, Su-Hua Yang, Ze-Yu Huang, Lin Lin, Xue-Cheng Tong, Hong Dai, Yuan Xue

Background and aim: Hepatic encephalopathy (HE) is a neuropsychiatric complication of liver failure with poor outcomes. The present study aimed to evaluate the predictive values of D-dimer in patients with HE.

Materials and methods: Patients with chronic liver failure (CLF) and HE were enrolled. Univariate and multivariate logistic analysis was performed to investigate the risk factors for 1-year mortality of HE.

Results: During the first year after diagnosis, 39.2% (65/166) of the patients died. D-dimer was significantly higher in non-survivors (Z=2.617, p<0.01). Both D-dimer and international normalized ratio (INR) positively correlated with Child-Pugh and MELD scores, and negatively correlated with sodium (all p<0.01). Moreover, there was a negative relationship between D-dimer and HE grades (r=-0.168, p=0.031), while the relationship between INR and HE grades was not significant (r=0.083, p=0.289). Multivariate analysis showed that age (odds ratio (OR):1.035, 95% CI:1.004-1.067, p=0.03), D-dimer (OR=1.138, 95% CI:1.030-1.258, p=0.01), ALT (OR=1.012, 95% CI:1.001-1.022, p=0.03), and sodium (OR=0.920, 95% CI:0.858-0.986, p=0.02) were independent risk factors for 1-year mortality. Then, a new model Model(Age_DD_ALT_Na) incorporating age, D-dimer, ALT, and sodium was developed. AUROC of Model(Age_DD_ALT_Na) was 0.732, which was significantly higher than MELD and Child-Pugh scores (AUROC: 0.602 and 0.599, p=0.013 and 0.022).

Conclusion: D-dimer is a prognostic marker for 1-year mortality in patients with CLF and HE.

背景和目的:肝性脑病(HE)是肝衰竭的一种神经精神并发症,治疗效果不佳。本研究旨在评估 D-二聚体对 HE 患者的预测价值:研究对象为慢性肝衰竭(CLF)和肝性脑病患者。采用单变量和多变量逻辑分析法研究肝衰竭患者1年死亡率的风险因素:结果:确诊后第一年,39.2%(65/166)的患者死亡。非存活者的 D-二聚体明显更高(Z=2.617,p 结论:D-二聚体是一种预后指标:D-二聚体是CLF和HE患者1年死亡率的预后指标。
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引用次数: 0
Leflunomide induced fatal dress syndrome need liver transplantation. 来氟米特诱发的致命着装综合征需要肝移植。
IF 1.2 Q4 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-09-10 eCollection Date: 2024-01-01 DOI: 10.14744/hf.2024.2024.0010
Ali Riza Caliskan, Mehmet Ali Erdogan

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe, potentially life-threatening, drug-induced hypersensitivity reaction that involves hematological abnormalities (atypical lymphocytosis, eosinophilia), lymphadenopathy, skin eruption, and internal organ involvement (lung, liver, kidney). The 36-year-old female patient was followed by bloody diarrhea, diffuse skin rashes and hepatitis. She was diagnosed with psoriatic arthritis, and Leflunomide 20 mg was added to the treatment six weeks ago. Upon developing hepatic encephalopathy and deepening the fulminant liver failure during the follow-up, a living donor liver from her son was transplanted on the 4th day of hospitalization. The patient had deceased on the second day after liver transplantation due to multiple organ failures. In the literature, mortality in DRESS syndrome is mostly secondary to hepatic failure. Liver transplantation cannot be effective due to systemic involvement and recurrence in the transplanted liver.

嗜酸性粒细胞增多和全身症状药物反应(DRESS)综合征是一种严重的、可能危及生命的药物超敏反应,包括血液学异常(非典型淋巴细胞增多、嗜酸性粒细胞增多)、淋巴结病、皮肤糜烂和内脏器官受累(肺、肝、肾)。这名 36 岁的女性患者随后出现血性腹泻、弥漫性皮疹和肝炎。她被诊断为银屑病关节炎,六周前开始在治疗中添加来氟米特 20 毫克。在随访期间出现肝性脑病并加深了暴发性肝衰竭,住院第 4 天移植了她儿子的活体肝脏。患者在肝移植后第二天因多器官功能衰竭而死亡。在文献中,DRESS 综合征的死亡率大多继发于肝功能衰竭。由于全身受累和移植肝脏复发,肝移植无法奏效。
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引用次数: 0
Intrabiliary pressure in the pathophysiology of extra hepatic biliary obstruction. 肝外胆道梗阻病理生理学中的胆道内压。
IF 1.2 Q4 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-09-10 eCollection Date: 2024-01-01 DOI: 10.14744/hf.2023.2023.0066
Dhananjay Saxena, Shridhar Vasantrao Sasturkar, Amar Mukund, Yashwant Patidar, Ashok Kumar Choudhury, Ragini Kilambi, Pratibha Kale

Background and aim: The aim of this study was to evaluate the role of intrabiliary pressure (IBP) in the pathophysiology of extrahepatic biliary obstruction (EHBO) during percutaneous transhepatic biliary drainage (PTBD).

Materials and methods: Adult patients with EHBO who underwent PTBD were prospectively enrolled. IBP was recorded during primary PTBD. The parameters of interest were age, gender, etiology of EHBO, baseline and post-PTBD liver function tests, duration for resolution of jaundice (decrease in total serum bilirubin ≥30% of baseline or <2 mg/dL), cholangitis, bile cultures, and serum albumin levels. The level of EHBO was divided into three types: Type 1 - secondary biliary confluence involved; Type 2 - primary biliary confluence involved; Type 3 - mid and distal common bile duct obstruction.

Results: IBP was measured in 102 patients, and finally, 87 patients, including 52 (59.77%) females, were analyzed. The mean age of the patients was 56.1±11.6 years. The most common etiology of EHBO was carcinoma of the gallbladder in 44 (50.6%) patients. The mean IBP was 18.41±3.91 mmHg. IBP was significantly higher in Type 3 EHBO compared to Type 1 and 2 (p=0.012). A significant correlation was seen between IBP and baseline total serum bilirubin (p<0.01). There was a negative correlation between IBP and baseline serum albumin (p=0.017). In 56.3% of patients, resolution of jaundice was observed by day 3, but this was not significantly associated with IBP (p=0.19). There was no correlation between IBP and cholangitis (p=0.97) or bacterial cultures (p=0.21).

Conclusion: IBP was significantly associated with the type of EHBO, baseline serum bilirubin, and albumin levels. IBP could not predict cholangitis or the resolution of jaundice after PTBD.

背景和目的:本研究旨在评估胆道内压力(IBP)在经皮经肝胆道引流术(PTBD)期间肝外胆道梗阻(EHBO)病理生理学中的作用:对接受经皮经肝胆道引流术(PTBD)的肝外胆道梗阻(EHBO)成人患者进行前瞻性研究。经皮经肝胆管引流术(PTBD)期间记录 IBP。相关参数包括年龄、性别、EHBO病因、基线和PTBD后肝功能检查、黄疸消退持续时间(血清总胆红素下降≥基线的30%或结果):对 102 名患者的 IBP 进行了测量,最后分析了 87 名患者,包括 52 名女性(59.77%)。患者的平均年龄为(56.1±11.6)岁。EHBO 最常见的病因是胆囊癌,有 44 例(50.6%)患者。平均 IBP 为 18.41±3.91 mmHg。3 型 EHBO 的 IBP 明显高于 1 型和 2 型(P=0.012)。IBP 与基线血清总胆红素之间存在明显相关性(p结论:IBP与EHBO类型、基线血清胆红素和白蛋白水平有明显相关性。IBP 无法预测胆管炎或 PTBD 后黄疸的消退。
{"title":"Intrabiliary pressure in the pathophysiology of extra hepatic biliary obstruction.","authors":"Dhananjay Saxena, Shridhar Vasantrao Sasturkar, Amar Mukund, Yashwant Patidar, Ashok Kumar Choudhury, Ragini Kilambi, Pratibha Kale","doi":"10.14744/hf.2023.2023.0066","DOIUrl":"10.14744/hf.2023.2023.0066","url":null,"abstract":"<p><strong>Background and aim: </strong>The aim of this study was to evaluate the role of intrabiliary pressure (IBP) in the pathophysiology of extrahepatic biliary obstruction (EHBO) during percutaneous transhepatic biliary drainage (PTBD).</p><p><strong>Materials and methods: </strong>Adult patients with EHBO who underwent PTBD were prospectively enrolled. IBP was recorded during primary PTBD. The parameters of interest were age, gender, etiology of EHBO, baseline and post-PTBD liver function tests, duration for resolution of jaundice (decrease in total serum bilirubin ≥30% of baseline or <2 mg/dL), cholangitis, bile cultures, and serum albumin levels. The level of EHBO was divided into three types: Type 1 - secondary biliary confluence involved; Type 2 - primary biliary confluence involved; Type 3 - mid and distal common bile duct obstruction.</p><p><strong>Results: </strong>IBP was measured in 102 patients, and finally, 87 patients, including 52 (59.77%) females, were analyzed. The mean age of the patients was 56.1±11.6 years. The most common etiology of EHBO was carcinoma of the gallbladder in 44 (50.6%) patients. The mean IBP was 18.41±3.91 mmHg. IBP was significantly higher in Type 3 EHBO compared to Type 1 and 2 (p=0.012). A significant correlation was seen between IBP and baseline total serum bilirubin (p<0.01). There was a negative correlation between IBP and baseline serum albumin (p=0.017). In 56.3% of patients, resolution of jaundice was observed by day 3, but this was not significantly associated with IBP (p=0.19). There was no correlation between IBP and cholangitis (p=0.97) or bacterial cultures (p=0.21).</p><p><strong>Conclusion: </strong>IBP was significantly associated with the type of EHBO, baseline serum bilirubin, and albumin levels. IBP could not predict cholangitis or the resolution of jaundice after PTBD.</p>","PeriodicalId":29722,"journal":{"name":"Hepatology Forum","volume":"5 4","pages":"198-203"},"PeriodicalIF":1.2,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11440221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Action of melatonin and physical exercise on the liver of cirrhotic rats: Study of oxidative stress and the inflammatory process. 褪黑激素和体育锻炼对肝硬化大鼠肝脏的作用:氧化应激和炎症过程研究
IF 1.2 Q4 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-09-01 eCollection Date: 2024-01-01 DOI: 10.14744/hf.2023.2023.0037
Gabriela S Martins, Carlos Gustavo S Rosa, Elizangela G Schemitt, Josieli R Colares, Sandielly Rb Fonseca, Marilda S Brasil, Millena O Engeroff, Norma P Marroni

Background and aim: Cirrhosis is characterized by structural and functional alterations of the liver. Melatonin (MLT) has antioxidant properties. Physical exercise (EX) can reverse muscle loss in cirrhotic patients. The objective was to evaluate the action of MLT and EX on the liver of rats subjected to the experimental model of bile duct ligation (BLD).

Materials and methods: 48 male Wistar rats were used, divided into groups: Control (CO), CO+MLT, CO+EX, CO+MLT+EX, BDL, BDL+MLT, BDL+EX, and BDL+MLT+EX. The treatments occurred from the 15th to the 28th day. The dose of MLT was 20 mg/kg via I.p (1x/day), and the EX was performed 10 min/day. Blood and liver were collected for analysis.

Results: The liver integrity enzymes AST, ALT, and ALP showed a significant reduction in the groups treated with MLT and EX. Histological analyses showed reorganization of the liver parenchyma, reduction of inflammatory infiltrate, and fibrotic nodules. Lipoperoxidation (LPO), the activity of antioxidant enzymes, and nitric oxide metabolites showed a significant reduction in the groups treated with MLT and EX. The expression of TNF-α and NF-kB decreased in the treated groups.

Conclusion: Melatonin and physical exercise seem to be effective in restoring the parameters evaluated in this model of experimental cirrhosis.

背景和目的:肝硬化以肝脏结构和功能改变为特征。褪黑素(MLT)具有抗氧化作用。体育锻炼(EX)可逆转肝硬化患者的肌肉损失。材料和方法:使用 48 只雄性 Wistar 大鼠,分为对照组(CO)、CO+MLT 组(CO+MLT 组)和 EX 组(EX 组):对照组(CO)、CO+MLT 组、CO+EX 组、CO+MLT+EX 组、BDL 组、BDL+MLT 组、BDL+EX 组和 BDL+MLT+EX 组。治疗时间为第 15 天至第 28 天。MLT的剂量为20毫克/千克,经静脉注射(1次/天),EX的剂量为10分钟/天。采集血液和肝脏进行分析:结果:接受 MLT 和 EX 治疗组的肝脏完整性酶 AST、ALT 和 ALP 显著降低。组织学分析表明,肝实质重组,炎症浸润和纤维化结节减少。脂肪过氧化(LPO)、抗氧化酶活性和一氧化氮代谢物在接受 MLT 和 EX 治疗的组别中显著减少。结论:结论:褪黑素和体育锻炼似乎能有效恢复实验性肝硬化模型中的评估指标。
{"title":"Action of melatonin and physical exercise on the liver of cirrhotic rats: Study of oxidative stress and the inflammatory process.","authors":"Gabriela S Martins, Carlos Gustavo S Rosa, Elizangela G Schemitt, Josieli R Colares, Sandielly Rb Fonseca, Marilda S Brasil, Millena O Engeroff, Norma P Marroni","doi":"10.14744/hf.2023.2023.0037","DOIUrl":"10.14744/hf.2023.2023.0037","url":null,"abstract":"<p><strong>Background and aim: </strong>Cirrhosis is characterized by structural and functional alterations of the liver. Melatonin (MLT) has antioxidant properties. Physical exercise (EX) can reverse muscle loss in cirrhotic patients. The objective was to evaluate the action of MLT and EX on the liver of rats subjected to the experimental model of bile duct ligation (BLD).</p><p><strong>Materials and methods: </strong>48 male Wistar rats were used, divided into groups: Control (CO), CO+MLT, CO+EX, CO+MLT+EX, BDL, BDL+MLT, BDL+EX, and BDL+MLT+EX. The treatments occurred from the 15<sup>th</sup> to the 28<sup>th</sup> day. The dose of MLT was 20 mg/kg via I.p (1x/day), and the EX was performed 10 min/day. Blood and liver were collected for analysis.</p><p><strong>Results: </strong>The liver integrity enzymes AST, ALT, and ALP showed a significant reduction in the groups treated with MLT and EX. Histological analyses showed reorganization of the liver parenchyma, reduction of inflammatory infiltrate, and fibrotic nodules. Lipoperoxidation (LPO), the activity of antioxidant enzymes, and nitric oxide metabolites showed a significant reduction in the groups treated with MLT and EX. The expression of TNF-α and NF-kB decreased in the treated groups.</p><p><strong>Conclusion: </strong>Melatonin and physical exercise seem to be effective in restoring the parameters evaluated in this model of experimental cirrhosis.</p>","PeriodicalId":29722,"journal":{"name":"Hepatology Forum","volume":"5 4","pages":"184-192"},"PeriodicalIF":1.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11440217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of triglyceride-glucose index and anthropometric obesity indices in predicting severe grades of hepatic steatosis in nonalcoholic fatty liver disease among non-diabetic obese individuals. 甘油三酯-葡萄糖指数与人体测量肥胖指数在预测非糖尿病肥胖者非酒精性脂肪肝肝脂肪变性严重程度方面的比较。
IF 1.2 Q4 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-07-02 eCollection Date: 2024-01-01 DOI: 10.14744/hf.2023.2023.0049
Huseyin Karaaslan, Hasan Inan, Alper Tunga Turkmen, Ismail Altintas, Nida Uyar, Mehmet Ali Eren

Background and aim: The triglyceride glucose index (TyG) has been proposed as a promising indicator of both insulin resistance (IR) and non-alcoholic fatty liver disease (NAFLD). However, the efficacy of the TyG index in predicting NAFLD has not been adequately studied, particularly in obese individuals.

Materials and methods: We analyzed 190 morbidly obese individuals. The TyG index, anthropometric obesity indices, homeostatic model assessment (HOMA-IR), and biochemical parameters were compared. NAFLD was diagnosed by hepatic ultrasonography and classified into four grades (0, 1, 2, and 3). Individuals in grades 2 and 3 are considered to have severe steatosis, while those in grades 0 and 1 do not.

Results: The area under the curve (AUC) values of the TyG index, body mass index, neck circumferences, waist-to-hip ratio, and HOMA-IR did not differ significantly in predicting severe steatosis (0.640, 0.742, 0.725, 0.620, and 0.624 respectively). However, the AUC values of waist circumference and alanine aminotransferase provided better predictions than the TyG index (0.782, 0.744, and 0.640 respectively).

Conclusion: The TyG index is highly effective in predicting both the presence and severity of NAFLD. However, it did not outperform simple obesity indices in predicting NAFLD and its severity in obese patients.

背景和目的:甘油三酯血糖指数(TyG)已被认为是胰岛素抵抗(IR)和非酒精性脂肪肝(NAFLD)的可靠指标。然而,TyG 指数在预测非酒精性脂肪肝方面的功效尚未得到充分研究,尤其是在肥胖人群中:我们对 190 名病态肥胖者进行了分析。对 TyG 指数、人体测量肥胖指数、稳态模型评估(HOMA-IR)和生化参数进行了比较。非酒精性脂肪肝通过肝脏超声波检查确诊,并分为四级(0、1、2 和 3)。2级和3级的人被认为有严重的脂肪变性,而0级和1级的人则没有:TyG指数、体重指数、颈围、腰臀比和HOMA-IR的曲线下面积(AUC)值在预测严重脂肪变性方面没有显著差异(分别为0.640、0.742、0.725、0.620和0.624)。然而,腰围和丙氨酸氨基转移酶的 AUC 值比 TyG 指数的预测效果更好(分别为 0.782、0.744 和 0.640):结论:TyG指数能有效预测非酒精性脂肪肝的存在和严重程度。结论:TyG 指数在预测是否存在非酒精性脂肪肝及其严重程度方面非常有效,但在预测肥胖患者的非酒精性脂肪肝及其严重程度方面,它并不优于简单的肥胖指数。
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引用次数: 0
Optimal testing strategies for incidental anti-mitochondrial M2 antibody-positive patients. 针对偶发性抗线粒体 M2 抗体阳性患者的最佳检测策略。
IF 1.2 Q4 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-07-02 eCollection Date: 2024-01-01 DOI: 10.14744/hf.2024.2024.0007
Ilkay Ergenc, Busra Gozaydinoglu, Caglayan Keklikkiran, Yusuf Yilmaz
{"title":"Optimal testing strategies for incidental anti-mitochondrial M2 antibody-positive patients.","authors":"Ilkay Ergenc, Busra Gozaydinoglu, Caglayan Keklikkiran, Yusuf Yilmaz","doi":"10.14744/hf.2024.2024.0007","DOIUrl":"10.14744/hf.2024.2024.0007","url":null,"abstract":"","PeriodicalId":29722,"journal":{"name":"Hepatology Forum","volume":"5 3","pages":"165-166"},"PeriodicalIF":1.2,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11237246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141617277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From NAFLD to MASLD: Meta-analysis and systematic review of NAFLD patients in Turkiye in terms of metabolic profile and MASLD potential. 从 NAFLD 到 MASLD:对土耳其 NAFLD 患者的代谢概况和 MASLD 潜力进行 Meta 分析和系统回顾。
IF 1.2 Q4 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-07-02 eCollection Date: 2024-01-01 DOI: 10.14744/hf.2023.2023.0042
Sevginur Akdas, Nuray Yazihan

Non-alcoholic Fatty Liver Disease (NAFLD) is both a cause and a consequence of metabolic disturbances. Consequently, the disease term has recently changed to Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). Turkiye is one of the leading countries with high incidences of diseases such as diabetes, obesity, metabolic syndrome, and fatty liver. This study aims to identify the metabolic parameters and MASLD potential of NAFLD in Turkiye. All NAFLD studies conducted in Turkiye were systematically searched using the keywords "fatty liver disease" AND " Turkiye " on PubMed, Scopus, and Web of Science databases. A total of 2653 articles were scanned, and 120 studies were eligible for meta-analysis. The metabolic parameters were meta-analyzed from a broad perspective. According to the meta-analysis results, there were significant increases in waist circumferences (mean difference: 10.90, p<0.00001), HOMA-IR (mean difference: 2.13, p<0.00001), aspartate aminotransferase (AST) (mean difference: 17.82, p<0.00001), systolic blood pressure (SBP) (mean difference: 5.86, p<0.00001), and C-reactive protein (CRP) levels (mean difference: 0.95, p<0.00001). These parameters are representative biochemical findings of disturbed glucose metabolism, lipid profile, blood pressure, and acute phase response mechanisms. Furthermore, the analysis of all related parameters commonly found among the articles confirmed these metabolic dysfunctions. NAFLD is a metabolic disease that encompasses multiple pathways related to glucose and lipid metabolism, vascular function, inflammation, and acute phase responses. Additionally, our results suggest that Turkish NAFLD patients identified in previous studies mostly have MASLD. This is the first meta-analysis study indicating changes in metabolism-related parameters with a cumulative meta-analysis of all Turkish NAFLD studies.

非酒精性脂肪肝(NAFLD)既是代谢紊乱的原因,也是代谢紊乱的结果。因此,该疾病的名称最近已改为代谢功能障碍相关性脂肪肝(MASLD)。土耳其是糖尿病、肥胖症、代谢综合征和脂肪肝等疾病高发的主要国家之一。本研究旨在确定土耳其非酒精性脂肪肝的代谢参数和 MASLD 可能性。在 PubMed、Scopus 和 Web of Science 数据库中,使用关键词 "脂肪肝 "和 "土耳其 "系统地搜索了在土耳其进行的所有非酒精性脂肪肝研究。共扫描了 2653 篇文章,其中 120 项研究符合荟萃分析条件。从广泛的角度对代谢参数进行了荟萃分析。根据荟萃分析结果,腰围明显增加(平均差异为 10.90,P<0.05):10.90, p
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引用次数: 0
The evolution and revolution of artificial intelligence in hepatology: From current applications to future paradigms. 人工智能在肝病学中的演变与革命:从当前应用到未来范例。
IF 1.2 Q4 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-07-02 eCollection Date: 2024-01-01 DOI: 10.14744/hf.2024.2024.ed0001
Cem Simsek
{"title":"The evolution and revolution of artificial intelligence in hepatology: From current applications to future paradigms.","authors":"Cem Simsek","doi":"10.14744/hf.2024.2024.ed0001","DOIUrl":"10.14744/hf.2024.2024.ed0001","url":null,"abstract":"","PeriodicalId":29722,"journal":{"name":"Hepatology Forum","volume":"5 3","pages":"97-99"},"PeriodicalIF":1.2,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11237248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141617279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Hepatology Forum
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