成软骨细胞瘤:10例细胞形态学分析并文献复习。

IF 1.6 4区 医学 Q3 PATHOLOGY Acta Cytologica Pub Date : 2023-01-01 DOI:10.1159/000528932
Carla Saoud, Paul E Wakely, Liron Pantanowitz, Momin T Siddiqui, Syed Z Ali
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引用次数: 1

摘要

成软骨细胞瘤(CB)是一种罕见的、产生软骨的良性肿瘤,通常影响骨骼未成熟个体的长骨骨骺。只有有限的病例报告描述了这种肿瘤的细胞形态学特征,因此细胞病理学诊断标准是有争议的。在此,我们报告了10例CB病例的细胞学结果,讨论了诊断标准和关键鉴别诊断,并对文献进行了全面的回顾。方法:我们对四家大型医疗机构的细胞病理学和外科病理学数据库中诊断为CB的病例进行了回顾性检索,这些病例具有相应的细胞学标本。所有可用的细胞病理学标本被检索和审查。记录临床病理和放射学资料。结果:8例患者10例,年龄15 ~ 42岁,平均24岁,其中男性5例。原发肿瘤8例,复发2例。3例发生在股骨,2例发生在肱骨,1例发生在关节盂、距骨和第3趾近端指骨。7例获得细胞学诊断。所有病例均可见肿瘤性单核细胞,其细胞学特征相似。细胞核呈圆形至卵圆形偏心,染色质分布均匀,核仁不明显;很少有核凹痕。多核巨细胞9例(90%)。细胞学检查有4例(40%)出现软骨粘液样基质碎片。8例可用细胞块。单核和多核巨细胞存在于所有适当的细胞块中,其细胞学特征与涂片中所见的相同。软骨基质仅存在于3个适当的细胞块中(43%)。结论:我们的结论是,在适当的临床和放射学背景下,如果存在特征性的成软骨细胞,则可以通过细胞学诊断CB。软骨粘液样基质的存在是一个有用的线索,但不是诊断所必需的。与外科病理学一样,骨肿瘤的细胞学评估应结合临床和放射学结果进行解释。
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Chondroblastoma: Cytomorphologic Analysis of 10 Cases with Review of the Literature.

Introduction: Chondroblastoma (CB) is a rare, benign cartilage-producing tumor, typically affecting the epiphysis of long bones in skeletally immature individuals. There have been only limited case reports describing the cytomorphologic features of this tumor, and thus the cytopathologic diagnostic criteria are controversial. Herein, we report the cytologic findings of 10 CB cases, discuss the diagnostic criteria and critical differential diagnosis, along with a comprehensive review of the literature.

Methods: We performed a retrospective search of our cytopathology and surgical pathology databases for cases diagnosed as CB that had corresponding cytology specimens from four large medical institutions. All available cytopathology specimens were retrieved and reviewed. Clinicopathologic and radiologic data were recorded.

Results: Ten cases were retrieved from 8 patients aged 15-42 years (mean, 24 years), five of whom were males. Eight cases represented primary tumors while 2 cases were recurrences. Three cases occurred in the femur, two cases occurred in the humerus, while 1 case occurred in each of the glenoid, talus, and proximal phalanx of the 3rd toe. The cytologic diagnosis of CB was achieved in 7 cases. The neoplastic mononuclear cells were present in all cases and their cytologic features were similar. These cells displayed round to oval eccentric nuclei, evenly distributed chromatin, and inconspicuous nucleoli; few of which had nuclear indentations. Multinucleated giant cells were present in 9 cases (90%). Fragments of chondromyxoid matrix were present in 4 cases on cytologic preparations (40%). Cell blocks were available in 8 cases. Mononuclear and multinucleated giant cells were present in all adequate cell blocks and their cytologic features were identical to those seen in the smears. The chondroid matrix was present in only three of the adequate cell blocks (43%).

Conclusion: We concluded that with the appropriate clinical and radiologic setting, the diagnosis of CB can be achieved on cytology if characteristic chondroblasts are present. The presence of chondromyxoid matrix is a helpful clue but is not necessary for the diagnosis. As in surgical pathology, cytologic evaluation of bone tumors should be interpreted in conjunction with clinical and radiologic findings.

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来源期刊
Acta Cytologica
Acta Cytologica 生物-病理学
CiteScore
3.70
自引率
11.10%
发文量
46
审稿时长
4-8 weeks
期刊介绍: With articles offering an excellent balance between clinical cytology and cytopathology, ''Acta Cytologica'' fosters the understanding of the pathogenetic mechanisms behind cytomorphology and thus facilitates the translation of frontline research into clinical practice. As the official journal of the International Academy of Cytology and affiliated to over 50 national cytology societies around the world, ''Acta Cytologica'' evaluates new and existing diagnostic applications of scientific advances as well as their clinical correlations. Original papers, review articles, meta-analyses, novel insights from clinical practice, and letters to the editor cover topics from diagnostic cytopathology, gynecologic and non-gynecologic cytopathology to fine needle aspiration, molecular techniques and their diagnostic applications. As the perfect reference for practical use, ''Acta Cytologica'' addresses a multidisciplinary audience practicing clinical cytopathology, cell biology, oncology, interventional radiology, otorhinolaryngology, gastroenterology, urology, pulmonology and preventive medicine.
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