{"title":"【CAR-T细胞治疗血液恶性肿瘤的现状及优化策略】","authors":"F C Wang, P Li, A B Liang","doi":"10.3760/cma.j.cn112138-20230410-00191","DOIUrl":null,"url":null,"abstract":"嵌合抗原受体T细胞(CAR-T细胞)疗法已成为治疗某些血液系统恶性肿瘤包括白血病、淋巴瘤和多发性骨髓瘤很有前途的一种治疗方式。然而耐药和疾病复发的出现,也给CAR-T细胞疗法提出了挑战。本文总结了目前CAR-T细胞疗法在中国的审批情况、提高CAR-T治疗效果方面的研究进展以及CAR-T细胞治疗遇到的挑战和未来方向,以期能为后续CAR-T治疗方案的优化提供借鉴。.","PeriodicalId":24000,"journal":{"name":"Zhonghua nei ke za zhi","volume":"62 6","pages":"581-586"},"PeriodicalIF":0.0000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[The current status and optimization strategies of CAR-T cell therapy in hematological malignancies].\",\"authors\":\"F C Wang, P Li, A B Liang\",\"doi\":\"10.3760/cma.j.cn112138-20230410-00191\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"嵌合抗原受体T细胞(CAR-T细胞)疗法已成为治疗某些血液系统恶性肿瘤包括白血病、淋巴瘤和多发性骨髓瘤很有前途的一种治疗方式。然而耐药和疾病复发的出现,也给CAR-T细胞疗法提出了挑战。本文总结了目前CAR-T细胞疗法在中国的审批情况、提高CAR-T治疗效果方面的研究进展以及CAR-T细胞治疗遇到的挑战和未来方向,以期能为后续CAR-T治疗方案的优化提供借鉴。.\",\"PeriodicalId\":24000,\"journal\":{\"name\":\"Zhonghua nei ke za zhi\",\"volume\":\"62 6\",\"pages\":\"581-586\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Zhonghua nei ke za zhi\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3760/cma.j.cn112138-20230410-00191\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zhonghua nei ke za zhi","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3760/cma.j.cn112138-20230410-00191","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}