迷走神经的发育和再生

IF 6.2 2区 生物学 Q1 CELL BIOLOGY Seminars in cell & developmental biology Pub Date : 2023-08-01 DOI:10.1016/j.semcdb.2023.07.008
Adam J. Isabella , Cecilia B. Moens
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引用次数: 1

摘要

迷走神经具有无数组成轴突分支和神经支配目标,长期以来一直是神经系统解剖复杂性的模型。迷走神经的分支结构现在被认为是高度组织的,围绕着支配每个目标组织的神经元的地形和/或分子特征。然而,我们才刚刚开始了解异质迷走神经神经元身份被指定、定型并用于引导特定神经元轴突到达特定目标的发育机制。在这里,我们总结了我们目前对迷走神经复杂的地形和分子组织的理解,支持这种组织的神经元规范和模式轴突引导的发育基础,以及促进或抑制神经损伤后迷走神经组织恢复的再生机制。最后,我们强调了这些领域中未解决的关键问题,并讨论了解决这些问题的潜在策略。
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Development and regeneration of the vagus nerve

The vagus nerve, with its myriad constituent axon branches and innervation targets, has long been a model of anatomical complexity in the nervous system. The branched architecture of the vagus nerve is now appreciated to be highly organized around the topographic and/or molecular identities of the neurons that innervate each target tissue. However, we are only just beginning to understand the developmental mechanisms by which heterogeneous vagus neuron identity is specified, patterned, and used to guide the axons of particular neurons to particular targets. Here, we summarize our current understanding of the complex topographic and molecular organization of the vagus nerve, the developmental basis of neuron specification and patterned axon guidance that supports this organization, and the regenerative mechanisms that promote, or inhibit, the restoration of vagus nerve organization after nerve damage. Finally, we highlight key unanswered questions in these areas and discuss potential strategies to address these questions.

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来源期刊
CiteScore
15.10
自引率
1.40%
发文量
310
审稿时长
9.1 weeks
期刊介绍: Seminars in Cell and Developmental Biology is a review journal dedicated to keeping scientists informed of developments in the field of molecular cell and developmental biology, on a topic by topic basis. Each issue is thematic in approach, devoted to an important topic of interest to cell and developmental biologists, focusing on the latest advances and their specific implications. The aim of each issue is to provide a coordinated, readable, and lively review of a selected area, published rapidly to ensure currency.
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