YKL-40作为帕金森病生物标志物和治疗靶点的早期研究

IF 2.3 Q3 CLINICAL NEUROLOGY Neurodegenerative disease management Pub Date : 2023-04-01 DOI:10.2217/nmt-2022-0010
Mai M Anwar, Mohamed H Fathi
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引用次数: 4

摘要

目的:探讨脑脊液(CSF)和脑YKL-40水平的测定是否可作为帕金森病(PD)的有效生物标志物。方法:将脂多糖(LPS)注入右侧黑质致密部(SNpc)。将大鼠分为:对照组、早期lps诱导PD组(14 d)和晚期lps诱导PD组(28 d)。脑脊液及脑组织中检测YKL-40等相关因子。结果:pd诱导大鼠脑组织和脑脊液中YKL-40的表达升高,与触发炎性细胞因子释放有关。结论:目前的研究仅限于检测脑和脑脊液中的YKL-40等炎症因子。YKL-40可能被认为是PD的早期生物标志物和治疗靶点。
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Early approaches of YKL-40 as a biomarker and therapeutic target for Parkinson's disease.

Aim: To investigate whether the estimation of cerebrospinal fluid (CSF) and brain YKL-40 levels may be used as an efficient biomarker for Parkinson's disease (PD). Methods: Lipopolysaccharides (LPS) was injected into the right substantia nigra pars compacta (SNpc). Rats were divided into: control group, early LPS-induced PD group (14 days), and advanced LPS-induced PD group (28 days). YKL-40 and other related factors were detected in CSF and brain tissue. Results: Increased expression of YKL-40 was observed in brain tissue and CSF of PD-induced rats associated with triggered inflammatory cytokine release. Conclusion: The current study was limited to detecting YKL-40 and other inflammatory factors in brain and CSF. YKL-40 may be considered as an early biomarker and therapeutic target for PD.

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CiteScore
4.30
自引率
0.00%
发文量
35
期刊最新文献
Investigation of nonmotor symptoms and their clinical correlates in patients with Parkinson's disease. Detailed investigation of the levodopa response rates in distinct motor subscores in Parkinson's disease patients with and without STN-DBS. Correction. Economic evaluation of mHealth solutions in PD: where do we stand? Advances in the management of Alzheimer's disease.
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