Rab22a在内体货物循环中的关键作用。

IF 3.6 3区 生物学 Q3 CELL BIOLOGY Traffic Pub Date : 2023-09-01 DOI:10.1111/tra.12907
Lingjie Kong, Shenghao Huang, Yuxuan Bao, Yingtong Chen, Chunyan Hua, Sheng Gao
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引用次数: 1

摘要

在几种ras相关的gtp结合蛋白(Rabs)的管理下,内体货物回收是亚细胞运输过程的核心,这些蛋白质由上游调节因子协调,并要求下游效应物发挥其功能。在这方面,除了Rab22a,其他几个Rabs已经得到了很好的评价。Rab22a是囊泡运输、早期核内体和再循环核内体形成的关键调节因子。值得注意的是,最近的研究表明Rab22a的免疫学作用与癌症、感染和自身免疫性疾病密切相关。本文综述了Rab22a的调控因子和效应因子。此外,我们还重点介绍了Rab22a在内体货物回收中的作用,包括在以Rab22a为核心的复合体的帮助下回收小管的生物发生,以及不同的内化货物如何在Rab22a、其效应物和调节剂的合作下选择不同的回收路线。值得注意的是,还讨论了与Rab22a对内体货物回收产生影响有关的矛盾和猜测。最后,本文简要介绍了Rab22a影响的各种事件,特别关注与Rab22a征用相关的内体成熟和内体货物循环,以及广泛研究的Rab22a的致癌作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Crucial roles of Rab22a in endosomal cargo recycling.

Endosomal cargo recycling lies at the heart of subcellular trafficking processes under the management of several Ras-related GTP-binding proteins (Rabs) which are coordinated by their upstream regulators and require their downstream effectors to display their functions. In this regard, several Rabs have been well-reviewed except Rab22a. Rab22a is a crucial regulator of vesicle trafficking, early endosome and recycling endosome formation. Notably, recent studies demonstrated the immunological roles of Rab22a, which are closely associated with cancers, infection and autoimmune disorders. This review provides an overview of the regulators and effectors of Rab22a. Also, we highlight the current knowledge of the role of Rab22a in endosomal cargo recycling, including the biogenesis of recycling tubules with the help of a complex with Rab22a at its core, and how different internalized cargo chooses different recycling routes thanks to the cooperation of Rab22a, its effectors and its regulators. Of note, contradictions and speculation related to endosomal cargo recycling that Rab22a brings impacts on are also discussed. Finally, this review endeavors to briefly introduce the various events impacted by Rab22a, particularly focusing on the commandeered Rab22a-associated endosomal maturation and endosomal cargo recycling, in addition to the extensively investigated oncogenic role of Rab22a.

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来源期刊
Traffic
Traffic 生物-细胞生物学
CiteScore
8.10
自引率
2.20%
发文量
50
审稿时长
2 months
期刊介绍: Traffic encourages and facilitates the publication of papers in any field relating to intracellular transport in health and disease. Traffic papers span disciplines such as developmental biology, neuroscience, innate and adaptive immunity, epithelial cell biology, intracellular pathogens and host-pathogen interactions, among others using any eukaryotic model system. Areas of particular interest include protein, nucleic acid and lipid traffic, molecular motors, intracellular pathogens, intracellular proteolysis, nuclear import and export, cytokinesis and the cell cycle, the interface between signaling and trafficking or localization, protein translocation, the cell biology of adaptive an innate immunity, organelle biogenesis, metabolism, cell polarity and organization, and organelle movement. All aspects of the structural, molecular biology, biochemistry, genetics, morphology, intracellular signaling and relationship to hereditary or infectious diseases will be covered. Manuscripts must provide a clear conceptual or mechanistic advance. The editors will reject papers that require major changes, including addition of significant experimental data or other significant revision. Traffic will consider manuscripts of any length, but encourages authors to limit their papers to 16 typeset pages or less.
期刊最新文献
Fluorescent Reporters, Imaging, and Artificial Intelligence Toolkits to Monitor and Quantify Autophagy, Heterophagy, and Lysosomal Trafficking Fluxes. Intercellular Mitochondrial Transfer: The Novel Therapeutic Mechanism for Diseases. Mechanistic Insights Into an Ancient Adenovirus Precursor Protein VII Show Multiple Nuclear Import Receptor Pathways. Dissociation of Drosophila Evi-Wg Complex Occurs Post Apical Internalization in the Maturing Acidic Endosomes. Post-Transcriptional Regulation of Rab7a in Lysosomal Positioning and Drug Resistance in Nutrient-Limited Cancer Cells.
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