所有鸡蛋放在一个篮子里:如何在一个帽独立的翻译事件中控制痘病毒感染

IF 6.2 2区 生物学 Q1 CELL BIOLOGY Seminars in cell & developmental biology Pub Date : 2023-10-01 DOI:10.1016/j.semcdb.2022.12.011
Helena Jaramillo-Mesa, Aurélie M. Rakotondrafara
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引用次数: 1

摘要

蛋白质合成的调节是病毒致病性的一个重要决定因素。Potyviridae家族是感染正义RNA病毒的植物中最大的家族。与感染小核糖核酸病毒科的动物相似,病毒核糖核酸基因组没有5′端,而是在其5′端连接了一种病毒蛋白(VPg)。Potyviral基因组主要依靠单个翻译事件翻译成一个大的多蛋白来表达其所有蛋白质库。在没有5′端帽的情况下,Potyviridae家族依靠其5′非翻译区(UTR)中的顺式作用元件来招募翻译机器。在这篇综述中,我们总结了Potyviridae家族所采用的各种5′UTR驱动的、与帽无关的翻译机制,包括扫描依赖性机制、内部启动和VPg的刺激作用。这些机制对potyviral致病性有直接影响,包括宿主范围特异性和耐药性。最后,我们讨论了这些病毒策略如何不仅为作物抗性的工程和/或育种提供新的途径,而且为开发植物系统中大规模蛋白质生产的生物技术工具提供机会。
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All eggs in one basket: How potyvirus infection is controlled at a single cap-independent translation event

Regulation of protein synthesis is a strong determinant of potyviral pathogenicity. The Potyviridae family is the largest family of plant-infecting positive sense RNA viruses. Similar to the animal-infecting Picornaviridae family, the potyviral RNA genome lacks a 5′ cap, and instead has a viral protein (VPg) linked to its 5′ end. Potyviral genomes are mainly translated into one large polyprotein relying on a single translation event to express all their protein repertoire. In the absence of the 5′ cap, the Potyviridae family depends on cis-acting elements in their 5′ untranslated regions (UTR) to recruit the translation machinery. In this review, we summarize the diverse 5′UTR-driven, cap-independent translation mechanisms employed by the Potyviridae family including scanning-dependent mechanism, internal initiation, and the stimulatory role of the VPg. These mechanisms have direct implications on potyviral pathogenicity, including host range specificity and resistance. Finally, we discuss how these viral strategies could not only inform new avenues for engineering and/or breeding for crop resistance but would also provide opportunities for the development of biotechnological tools for large-scale protein production in plant systems.

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来源期刊
CiteScore
15.10
自引率
1.40%
发文量
310
审稿时长
9.1 weeks
期刊介绍: Seminars in Cell and Developmental Biology is a review journal dedicated to keeping scientists informed of developments in the field of molecular cell and developmental biology, on a topic by topic basis. Each issue is thematic in approach, devoted to an important topic of interest to cell and developmental biologists, focusing on the latest advances and their specific implications. The aim of each issue is to provide a coordinated, readable, and lively review of a selected area, published rapidly to ensure currency.
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