{"title":"口服异维甲酸治疗青少年痤疮及精神不良反应的系统综述。","authors":"Tânia Fernandes, Sofia Magina","doi":"10.1080/15569527.2023.2227889","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Acne vulgaris is a very prevalent dermatological condition, especially among adolescents and young adults up to 25 years old, classifying it as juvenile acne. One of the most effective treatments for severe acne is isotretinoin, a derivative of retinoic acid. Despite its high efficacy, this drug has been linked to several side effects including psychiatric adverse alterations, such as anxiety, depression and even suicide. With this systematic review we aim to determine if it is possible to establish a causal relation between oral isotretinoin in the treatment of juvenile acne and the appearance of psychiatric adverse effects.</p><p><strong>Materials and methods: </strong>We searched two distinct databases, PubMed and Web of Science, and considered the work published between January 2000 and November 2021.</p><p><strong>Results: </strong>Out of the 599 identified articles, we included 19 studies in this systematic review. Globally, the results we found do not support an association between the use of isotretinoin for acne treatment and mental side effects and the safety of this drug appears to be assured. However, the individual characteristics of each adolescent and their environment should be considered; the personal and family history of mental disorders are pointed out as red flags we should look out for when treating these patients.</p><p><strong>Conclusion: </strong>Despite this being a highly debated topic, especially among the dermatology community, more studies with larger populations and randomised controlled trials are necessary to increase the strength of the evidence presented.</p>","PeriodicalId":11023,"journal":{"name":"Cutaneous and Ocular Toxicology","volume":null,"pages":null},"PeriodicalIF":1.6000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Oral isotretinoin in the treatment of juvenile acne and psychiatric adverse effects - a systematic review.\",\"authors\":\"Tânia Fernandes, Sofia Magina\",\"doi\":\"10.1080/15569527.2023.2227889\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Acne vulgaris is a very prevalent dermatological condition, especially among adolescents and young adults up to 25 years old, classifying it as juvenile acne. One of the most effective treatments for severe acne is isotretinoin, a derivative of retinoic acid. Despite its high efficacy, this drug has been linked to several side effects including psychiatric adverse alterations, such as anxiety, depression and even suicide. With this systematic review we aim to determine if it is possible to establish a causal relation between oral isotretinoin in the treatment of juvenile acne and the appearance of psychiatric adverse effects.</p><p><strong>Materials and methods: </strong>We searched two distinct databases, PubMed and Web of Science, and considered the work published between January 2000 and November 2021.</p><p><strong>Results: </strong>Out of the 599 identified articles, we included 19 studies in this systematic review. Globally, the results we found do not support an association between the use of isotretinoin for acne treatment and mental side effects and the safety of this drug appears to be assured. However, the individual characteristics of each adolescent and their environment should be considered; the personal and family history of mental disorders are pointed out as red flags we should look out for when treating these patients.</p><p><strong>Conclusion: </strong>Despite this being a highly debated topic, especially among the dermatology community, more studies with larger populations and randomised controlled trials are necessary to increase the strength of the evidence presented.</p>\",\"PeriodicalId\":11023,\"journal\":{\"name\":\"Cutaneous and Ocular Toxicology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2023-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cutaneous and Ocular Toxicology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/15569527.2023.2227889\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cutaneous and Ocular Toxicology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/15569527.2023.2227889","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
目的:寻常痤疮是一种非常普遍的皮肤病,特别是在青少年和25岁以下的年轻人中,将其归类为青少年痤疮。治疗严重痤疮最有效的方法之一是异维甲酸,它是维甲酸的衍生物。尽管这种药物疗效很高,但它也有一些副作用,包括精神上的不良改变,如焦虑、抑郁甚至自杀。通过这一系统综述,我们的目的是确定是否有可能在口服异维甲酸治疗青少年痤疮和出现精神不良反应之间建立因果关系。材料和方法:我们检索了两个不同的数据库,PubMed和Web of Science,并考虑了2000年1月至2021年11月之间发表的作品。结果:在599篇确定的文章中,我们纳入了19项研究。在全球范围内,我们发现的结果并不支持使用异维甲酸治疗痤疮与精神副作用之间的联系,而且这种药物的安全性似乎得到了保证。但是,应该考虑到每个青少年的个人特点及其环境;精神障碍的个人和家族史被指出是我们在治疗这些患者时应该注意的危险信号。结论:尽管这是一个备受争议的话题,特别是在皮肤学界,但需要更多的大规模研究和随机对照试验来增加证据的强度。
Oral isotretinoin in the treatment of juvenile acne and psychiatric adverse effects - a systematic review.
Purpose: Acne vulgaris is a very prevalent dermatological condition, especially among adolescents and young adults up to 25 years old, classifying it as juvenile acne. One of the most effective treatments for severe acne is isotretinoin, a derivative of retinoic acid. Despite its high efficacy, this drug has been linked to several side effects including psychiatric adverse alterations, such as anxiety, depression and even suicide. With this systematic review we aim to determine if it is possible to establish a causal relation between oral isotretinoin in the treatment of juvenile acne and the appearance of psychiatric adverse effects.
Materials and methods: We searched two distinct databases, PubMed and Web of Science, and considered the work published between January 2000 and November 2021.
Results: Out of the 599 identified articles, we included 19 studies in this systematic review. Globally, the results we found do not support an association between the use of isotretinoin for acne treatment and mental side effects and the safety of this drug appears to be assured. However, the individual characteristics of each adolescent and their environment should be considered; the personal and family history of mental disorders are pointed out as red flags we should look out for when treating these patients.
Conclusion: Despite this being a highly debated topic, especially among the dermatology community, more studies with larger populations and randomised controlled trials are necessary to increase the strength of the evidence presented.
期刊介绍:
Cutaneous and Ocular Toxicology is an international, peer-reviewed journal that covers all types of harm to cutaneous and ocular systems. Areas of particular interest include pharmaceutical and medical products; consumer, personal care, and household products; and issues in environmental and occupational exposures.
In addition to original research papers, reviews and short communications are invited, as well as concise, relevant, and critical reviews of topics of contemporary significance.