芯片实验室中了解健康和疾病障碍的模型。

IF 3.6 Q2 MEDICINE, RESEARCH & EXPERIMENTAL Tissue Barriers Pub Date : 2024-04-02 Epub Date: 2023-06-09 DOI:10.1080/21688370.2023.2221632
J Ponmozhi, S Dhinakaran, Dorottya Kocsis, Kristóf Iván, Franciska Erdő
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引用次数: 0

摘要

人体平衡的维持在很大程度上依赖于生理屏障。这些屏障的功能失调会导致各种病理过程,包括增加接触有毒物质和微生物的机会。目前有多种方法来研究体内和体外的屏障功能。为了以高度可重复性、符合道德规范和高通量的方式研究屏障功能,研究人员转向了非动物技术和微尺度技术。在这篇综合性综述中,作者总结了器官芯片微流控装置在生理屏障研究中的应用现状。综述涵盖了健康和病理条件下的血脑屏障、眼屏障、皮肤屏障、呼吸屏障、肠屏障、肝胆屏障和肾/膀胱屏障。然后,文章简要介绍了器官芯片设备中的胎盘/阴道和肿瘤/多器官屏障。最后,文章讨论了微流控系统中集成生物屏障的计算流体力学。本文简明而翔实地概述了目前利用微流体设备进行屏障研究的最新进展。
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Models for barrier understanding in health and disease in lab-on-a-chips.

The maintenance of body homeostasis relies heavily on physiological barriers. Dysfunction of these barriers can lead to various pathological processes, including increased exposure to toxic materials and microorganisms. Various methods exist to investigate barrier function in vivo and in vitro. To investigate barrier function in a highly reproducible manner, ethically, and high throughput, researchers have turned to non-animal techniques and micro-scale technologies. In this comprehensive review, the authors summarize the current applications of organ-on-a-chip microfluidic devices in the study of physiological barriers. The review covers the blood-brain barrier, ocular barriers, dermal barrier, respiratory barriers, intestinal, hepatobiliary, and renal/bladder barriers under both healthy and pathological conditions. The article then briefly presents placental/vaginal, and tumour/multi-organ barriers in organ-on-a-chip devices. Finally, the review discusses Computational Fluid Dynamics in microfluidic systems that integrate biological barriers. This article provides a concise yet informative overview of the current state-of-the-art in barrier studies using microfluidic devices.

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来源期刊
Tissue Barriers
Tissue Barriers MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
6.60
自引率
6.50%
发文量
25
期刊介绍: Tissue Barriers is the first international interdisciplinary journal that focuses on the architecture, biological roles and regulation of tissue barriers and intercellular junctions. We publish high quality peer-reviewed articles that cover a wide range of topics including structure and functions of the diverse and complex tissue barriers that occur across tissue and cell types, including the molecular composition and dynamics of polarized cell junctions and cell-cell interactions during normal homeostasis, injury and disease state. Tissue barrier formation in regenerative medicine and restoration of tissue and organ function is also of interest. Tissue Barriers publishes several categories of articles including: Original Research Papers, Short Communications, Technical Papers, Reviews, Perspectives and Commentaries, Hypothesis and Meeting Reports. Reviews and Perspectives/Commentaries will typically be invited. We also anticipate to publish special issues that are devoted to rapidly developing or controversial areas of research. Suggestions for topics are welcome. Tissue Barriers objectives: Promote interdisciplinary awareness and collaboration between researchers working with epithelial, epidermal and endothelial barriers and to build a broad and cohesive worldwide community of scientists interesting in this exciting field. Comprehend the enormous complexity of tissue barriers and map cross-talks and interactions between their different cellular and non-cellular components. Highlight the roles of tissue barrier dysfunctions in human diseases. Promote understanding and strategies for restoration of tissue barrier formation and function in regenerative medicine. Accelerate a search for pharmacological enhancers of tissue barriers as potential therapeutic agents. Understand and optimize drug delivery across epithelial and endothelial barriers.
期刊最新文献
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