主动脉瓣再植术修复及维持关节定向的效果。

IF 3.3 2区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Annals of cardiothoracic surgery Pub Date : 2023-07-31 DOI:10.21037/acs-2023-avs2-18
John J Kelly, Nimesh D Desai, William L Patrick, Brittany J Cannon, Yu Zhao, Selim Mosbahi, Mikolaj Berezowksi, Amit Iyengar, Wilson Y Szeto, Joseph E Bavaria
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引用次数: 0

摘要

背景:对于非常不对称的双尖瓣主动脉瓣(BAV),是否应该完成保留瓣根再植(VSRR),以保留原关节的不对称取向,或者是否应该使其对称(180°-180°),争论仍然存在。在此,我们提出了我们的方法,其中保留了原有的不对称性,并将瓣膜重新植入210°-150°方向。方法:回顾性分析2004年1月1日至2023年3月1日在同一医院接受VSRR治疗的130例BAV患者。其中37例不对称移植(210°-150°)。主要结局为>中度主动脉不全(AI)。次要结局包括严重主动脉瓣狭窄(AS)、再干预和生存。结果:37例患者以男性居多[94.6%(35/37)],平均年龄46.3岁,合并症发生率低。40.5%(15/37)的患者在手术前至少存在中度AI。本组病例均为Sievers 1型,平均相交角为128.2°。81.1%(30/37)需要小叶修复,最常见的是连体尖中央应用[96.7%(29/30)]和中缝松解[73.3%(22/30)]。没有30天死亡率或中风。10年时,>中度AI、重度AS和再干预的累积发生率分别为7.6%(0-17.2%)、7.1%(0-19.7%)和5.3%(0.3-22%)。在整个研究期间没有死亡率。结论:该系列研究表明,在不对称BAV再植手术中,保持关节朝向的10年预后良好。然而,需要更多患者的进一步研究,更长的随访时间,并直接比较相似BAV形态的对称再植。
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Outcomes of aortic valve repair with the reimplantation technique and maintenance of commissural orientation.

Background: Debate still persists on whether valve-sparing root reimplantation (VSRR) of a very asymmetric bicuspid aortic valve (BAV) should be completed such that the asymmetry of the native commissural orientation is retained, or if it should be made symmetric (180°-180°). Herein, we present our approach, in which the native asymmetry is preserved, and the valve is reimplanted in a 210°-150° orientation.

Methods: A retrospective review was performed of 130 patients with BAV who underwent VSRR between January 1, 2004 and March 1, 2023 at a single institution. Of this total, 37 were reimplanted asymmetrically (210°-150°). The primary outcome was > moderate aortic insufficiency (AI). Secondary outcomes included severe aortic stenosis (AS), reintervention, and survival.

Results: The included 37 patients were mostly male [94.6% (35/37)] with mean age of 46.3 years, and with low rates of comorbidities. At least moderate AI was present in 40.5% (15/37) prior to surgery. All BAV in this series were Sievers Type 1 with a mean commissural angle of 128.2°. Leaflet repair was required in 81.1% (30/37), most commonly involving central plication of the conjoined cusp [96.7% (29/30)] and raphe release [73.3% (22/30)]. There was no 30-day mortality or stroke. At 10 years, the cumulative incidences of > moderate AI, severe AS, and reintervention were 7.6% (0-17.2%), 7.1% (0-19.7%), and 5.3% (0.3-22%), respectively. There was no mortality for the entire duration of the study period.

Conclusions: This series demonstrates excellent 10-year outcomes of maintaining commissural orientation in asymmetric BAV reimplantation procedures. However, further study with additional patients, longer follow-up, and direct comparison to symmetric reimplantation for similar BAV morphology is required.

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