犬急性胰腺炎红细胞分布宽度、中性粒细胞与淋巴细胞比率及其他血液学参数的评估。

IF 1.1 3区 农林科学 Q3 VETERINARY SCIENCES Journal of veterinary emergency and critical care Pub Date : 2023-08-12 DOI:10.1111/vec.13325
Meghan M. Johnson DVM, CVA, DACVECC, John C. Gicking DVM, DACVECC, Deborah A. Keys PhD
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引用次数: 0

摘要

目的:通过犬急性胰腺炎(AP)的犬急性胰腺炎严重程度(CAPS)评分,确定红细胞分布宽度(RDW)、中性粒细胞与淋巴细胞比率(NLR)和其他血液学参数是否与住院死亡率、住院时间(LOH)或疾病严重程度的增加有关,2016年1月至2020年8月的多中心研究。设置:四个私人急诊和专科转诊中心。动物:在最初的病例搜索中,118只客户拥有的狗被确认为AP的临床诊断。在这些病例中,114只狗符合纳入标准,定义为突然出现≥2种兼容的临床症状(嗜睡、厌食、呕吐或腹痛),特定的犬胰脂肪酶浓度>400μg/L,入院,以及首次住院后48小时内的CBC和血清生物化学检查。除了LOH和住院死亡率外,还使用CAPS评分计算和测量疾病严重程度。干预措施:无。测量和主要结果:根据CAPS评分评估,临床终点为住院死亡率、LOH和疾病严重程度。住院总死亡率为36.8%,较高的百分比与不存活的可能性增加有关(比值比:1.1,95%置信区间:1.0-1.2;P=0.006,调整后P=0.04)当RDW、血小板与淋巴细胞的比率、WBC计数、平均血小板体积、RDW与血小板的比率或RDW与血清总钙的比率与结果指标进行评估时,注意到显著的相关性。结论:本研究回顾性评估了几种容易获得的血液学参数对AP住院犬预后的影响。NLR增加的狗可能有更高的住院死亡率和LOH增加的风险,尽管未来的前瞻性研究有必要证实这些发现。
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Evaluation of red blood cell distribution width, neutrophil-to-lymphocyte ratio, and other hematologic parameters in canine acute pancreatitis

Objective

To determine if RBC distribution width (RDW), neutrophil-to-lymphocyte ratio (NLR), and other hematological parameters are associated with increased odds of in-hospital mortality, increased length of hospitalization (LOH), or disease severity as measured by the Canine Acute Pancreatitis Severity (CAPS) score in dogs with acute pancreatitis (AP).

Design

Retrospective, multicenter study from January 2016 to August 2020.

Setting

Four private emergency and specialty referral centers.

Animals

On initial case search, 118 client-owned dogs were identified with a clinical diagnosis of AP. Out of these cases, 114 dogs met inclusion criteria, defined as sudden onset of ≥2 compatible clinic signs (lethargy, anorexia, vomiting, or abdominal pain), a specific canine pancreatic lipase concentration >400 μg/L, hospital admission, as well as CBC and serum biochemistry run within 48 hours of initial hospitalization. Disease severity was calculated and measured using the CAPS score, in addition to LOH and in-hospital mortality.

Interventions

None.

Measurements and Main Results

Clinical endpoints were in-hospital mortality, LOH, and disease severity, as evaluated by the CAPS score. Overall in-hospital mortality was 36.8%. NLR was significantly associated with survival, with a higher percentage being associated with an increased likelihood of nonsurvival (odds ratio: 1.1, 95% confidence interval: 1.0–1.2; P = 0.006, adjusted P = 0.04). Increased NLR was found to be significantly associated with a longer LOH based on the unadjusted P-value (P = 0.02) but was not statistically significant based on a P-value adjusted for multiple comparisons (P = 0.12). No significant associations were noted when RDW, platelet-to-lymphocyte ratio, WBC count, mean platelet volume, RDW-to-platelet ratio, or RDW-to-total serum calcium ratio was evaluated against outcome measures.

Conclusions

This study retrospectively evaluated the prognostic utility of several readily available hematological parameters in dogs hospitalized for AP. Dogs with an increased NLR may have a higher risk of in-hospital mortality and increased LOH, although future prospective studies are necessary to confirm these findings.

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来源期刊
CiteScore
2.50
自引率
15.40%
发文量
121
审稿时长
18-36 weeks
期刊介绍: The Journal of Veterinary Emergency and Critical Care’s primary aim is to advance the international clinical standard of care for emergency/critical care patients of all species. The journal’s content is relevant to specialist and non-specialist veterinarians practicing emergency/critical care medicine. The journal achieves it aims by publishing descriptions of unique presentation or management; retrospective and prospective evaluations of prognosis, novel diagnosis, or therapy; translational basic science studies with clinical relevance; in depth reviews of pertinent topics; topical news and letters; and regular themed issues. The journal is the official publication of the Veterinary Emergency and Critical Care Society, the American College of Veterinary Emergency and Critical Care, the European Veterinary Emergency and Critical Care Society, and the European College of Veterinary Emergency and Critical Care. It is a bimonthly publication with international impact and adheres to currently accepted ethical standards.
期刊最新文献
Fabio Viganó Jennifer J. Devey Issue Information - Prelim AUTHOR INDEX Abstracts from the International Veterinary Emergency and Critical Care Symposium and the European Veterinary Emergency and Critical Care Annual Congress 2024
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