用于发现新型天然产品及其衍生物的宿主工程和体外酶合成。

IF 8.1 2区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Critical Reviews in Biotechnology Pub Date : 2024-09-01 Epub Date: 2023-08-13 DOI:10.1080/07388551.2023.2236787
Huanyu Zhang, Lanping Guo, Yaowu Su, Rubing Wang, Wenqi Yang, Wenrong Mu, Liangshuang Xuan, Luqi Huang, Juan Wang, Wenyuan Gao
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引用次数: 0

摘要

新型天然产物(NPs)及其衍生物是药物发现的重要来源,已广泛应用于农业、畜牧业和医药领域,因此 NPs 及其衍生物的合成必然十分重要。近年来,生物合成技术因其在合成高附加值新型产品方面的高效率以及绿色、环保、可控等优势而受到越来越多的关注。本综述概述了生物合成策略在发现新型 NPs 及其衍生物方面的技术进展,重点关注宿主工程和体外酶法合成两个领域。在宿主工程方面,多年来,包括链霉菌、曲霉和青霉在内的多种微生物被用作生物合成基因簇(BGCs)的提供者和表达BGCs的宿主菌株,以发现新化合物。此外,本文还介绍了利用体外酶合成策略生成三萜类皂甙和黄酮类等新型化合物的方法。
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Hosts engineering and in vitro enzymatic synthesis for the discovery of novel natural products and their derivatives.

Novel natural products (NPs) and their derivatives are important sources for drug discovery, which have been broadly applied in the fields of agriculture, livestock, and medicine, making the synthesis of NPs and their derivatives necessarily important. In recent years, biosynthesis technology has received increasing attention due to its high efficiency in the synthesis of high value-added novel products and its advantages of green, environmental protection, and controllability. In this review, the technological advances of biosynthesis strategies in the discovery of novel NPs and their derivatives are outlined, with an emphasis on two areas of host engineering and in vitro enzymatic synthesis. In terms of hosts engineering, multiple microorganisms, including Streptomyces, Aspergillus, and Penicillium, have been used as the biosynthetic gene clusters (BGCs) provider and host strain for the expression of BGCs to discover new compounds over the past years. In addition, the use of in vitro enzymatic synthesis strategy to generate novel compounds such as triterpenoid saponins and flavonoids is also hereby described.

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来源期刊
Critical Reviews in Biotechnology
Critical Reviews in Biotechnology 工程技术-生物工程与应用微生物
CiteScore
20.80
自引率
1.10%
发文量
71
审稿时长
4.8 months
期刊介绍: Biotechnological techniques, from fermentation to genetic manipulation, have become increasingly relevant to the food and beverage, fuel production, chemical and pharmaceutical, and waste management industries. Consequently, academic as well as industrial institutions need to keep abreast of the concepts, data, and methodologies evolved by continuing research. This journal provides a forum of critical evaluation of recent and current publications and, periodically, for state-of-the-art reports from various geographic areas around the world. Contributing authors are recognized experts in their fields, and each article is reviewed by an objective expert to ensure accuracy and objectivity of the presentation.
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