Acute Toxicity Study of 5, 11-Dihydroindolo [3, 2-ß]carbazole as per OECD Regulatory Guidelines.

Q3 Pharmacology, Toxicology and Pharmaceutics Current drug discovery technologies Pub Date : 2023-01-01 DOI:10.2174/1570163819666220429095155

Navyashree V Gowda, Shailesh Bhosale, Anoop Kumar

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Abstract

Background: 5,11-Dihydroindolo [3, 2-ß]carbazole is one of the phytoconstituent of the Arisaema genus, which might have various important biological activities. Recently, we have predicted the antiviral potential of this phytoconstituent against the Japanese Encephalitis virus (JEV).

Methods: Thus, in the current study, the acute toxicity profile of 5, 11-dihydroindolo [3, 2-ß]carbazole as per OECD regulatory guidelines in female Wistar rats was evaluated.

Results: We did not find any adverse effects, mortality, and altered behaviour in animals after administration of 5, 11-dihydroindolo [3, 2-ß] carbazole at a dose of 300 and 2000 mg/Kg. Furthermore, no significant changes in physiological and haematological parameters were observed. The histopathological study of vital organs also showed no significant changes compared to the control.

Conclusion: Based on the findings of the current investigation, 5, 11-dihydroindolo [3, 2-ß]carbazole is a safe phytoconstituent of the Arisaema genus, which can be explored for various biological activities.

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根据经合组织监管指南研究5,11 -二氢吲哚[3,2 -ß]咔唑的急性毒性。

背景:5,11-二氢吲哚[3,2 -ß]咔唑是鸢尾属植物成分之一，可能具有多种重要的生物活性。最近，我们预测了该植物成分对日本脑炎病毒(JEV)的抗病毒潜力。方法:因此，在本研究中，根据OECD监管指南评估了5,11 -二氢吲哚[3,2 -ß]咔唑对雌性Wistar大鼠的急性毒性。结果:我们未发现300和2000 mg/Kg剂量的5,11 -二氢吲哚[3,2 -ß]咔唑对动物有任何不良反应、死亡率和行为改变。此外，未观察到生理和血液学参数的显著变化。与对照组相比，重要器官的组织病理学研究也没有明显变化。结论:根据目前的研究结果，5,11 -二氢吲哚[3,2 -ß]咔唑是一种安全的鸢尾属植物成分，可开发多种生物活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current drug discovery technologies Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

CiteScore

3.70

自引率

0.00%

发文量

期刊介绍： Due to the plethora of new approaches being used in modern drug discovery by the pharmaceutical industry, Current Drug Discovery Technologies has been established to provide comprehensive overviews of all the major modern techniques and technologies used in drug design and discovery. The journal is the forum for publishing both original research papers and reviews describing novel approaches and cutting edge technologies used in all stages of drug discovery. The journal addresses the multidimensional challenges of drug discovery science including integration issues of the drug discovery process.