CBD: A Potential Lead against Hair Loss, Alopecia, and its Potential Mechanisms.

Q3 Pharmacology, Toxicology and Pharmaceutics Current drug discovery technologies Pub Date : 2024-01-01 DOI:10.2174/1570163820666230720153607

Pranay Wal, Ankita Wal

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Abstract

Background: Nowadays, the majority of the population suffers from the problem of hair loss. It leads to disturbed mental health, lower self-confidence, and a lot more problems. A lot of the hair loss therapies available are not reliable and lead to recurrence and side effects after some time. Cannabinoids (CBD) have recently become quite popular for their benefits against hair loss. CBD oil preparations have been used both internally and externally for oral and topical use, respectively. Due to the presence of the endocannabinoid system (ECS) in the body, which naturally targets CB1 and CB2 receptors, the control of hair fall is possible. CBD is used topically for hair loss, whereas it is administered orally for the treatment and management of a medical condition, i.e., alopecia.

Aim/objective: The present review aimed to provide an in-depth study on hair loss and its management using CBD and its associated mechanisms.

Methods: Electronic databases, such as ScienceDirect, Google Scholar, PubMed, Wiley, Springer, and Scopus, were thoroughly searched for information about how CBD is used, how it works, and what role it plays in treating alopecia and hair loss.

Results: This review has highlighted the use of CBD-based hair loss therapy, and described various types of hair loss and their treatments. This review also details the phytocannabinoids and the potential mechanisms of CBD's activity against hair loss and alopecia.

Conclusion: The data obtained from the literature regarding CBD and hair loss provide a scientific basis for CBD use in alopecia. Additionally, a more precise and comprehensive study concerning CBD needs to be carried out at the pre-clinical and clinical levels.

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CBD：治疗脱发和脱发症的潜在药物及其潜在机制。

背景：如今，大多数人都受到脱发问题的困扰。脱发会导致心理健康受到干扰、自信心下降以及其他许多问题。很多脱发疗法并不可靠，一段时间后会复发并产生副作用。最近，大麻素（CBD）因其对脱发的益处而颇受欢迎。CBD 油制剂已分别用于口服和外用。由于体内存在内源性大麻素系统（ECS），其天然目标是 CB1 和 CB2 受体，因此可以控制掉发。CBD 可用于局部治疗脱发，而口服 CBD 则可用于治疗和控制脱发等病症：本综述旨在深入研究使用 CBD 治疗脱发及其相关机制：方法：彻底搜索了 ScienceDirect、Google Scholar、PubMed、Wiley、Springer 和 Scopus 等电子数据库，以了解有关如何使用 CBD、CBD 如何发挥作用以及 CBD 在治疗脱发和脱发中发挥的作用的信息：本综述重点介绍了使用 CBD 治疗脱发的情况，并描述了各种类型的脱发及其治疗方法。本综述还详细介绍了植物大麻素以及 CBD 治疗脱发和脱发的潜在机制：从文献中获得的有关 CBD 和脱发的数据为将 CBD 用于治疗脱发提供了科学依据。此外，还需要在临床前和临床层面对 CBD 进行更精确、更全面的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current drug discovery technologies Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

CiteScore

3.70

自引率

0.00%

发文量

期刊介绍： Due to the plethora of new approaches being used in modern drug discovery by the pharmaceutical industry, Current Drug Discovery Technologies has been established to provide comprehensive overviews of all the major modern techniques and technologies used in drug design and discovery. The journal is the forum for publishing both original research papers and reviews describing novel approaches and cutting edge technologies used in all stages of drug discovery. The journal addresses the multidimensional challenges of drug discovery science including integration issues of the drug discovery process.