Antifungal Effect of Carrot Carotenoids on Candida Species.

Q3 Pharmacology, Toxicology and Pharmaceutics Current drug discovery technologies Pub Date : 2023-01-01 DOI:10.2174/1570163820666230227113802

Neda Askari, Mahboobeh Madani, Masoud Fouladgar, Pegah Shakib

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引用次数: 1

Abstract

Background: Candidiasis is a serious problem in women's health that is caused by Candida species, especially Candida albicans. In this study, the effect of carotenoids in carrot extracts on Candida species including Candida albicans ATCC1677, Candida glabrata CBS2175, Candida parapsilosis ATCC2195, and Candida tropicalis CBS94 was investigated.

Methods: In this descriptive study, the carrot plant was prepared from a carrot planting site in December 2012, and then the characteristics of the plant were determined. After extracting carotenoids from carrots, the susceptibility of different Candida species to carotenoids in carrot extract was determined. Also, the minimum inhibitory concentration and the minimum lethal concentration of the extracts were measured by the macro-dilution method. Finally, the data were analyzed by SPSS software using the Kruskal-Wallis test and Mann-Whitney post-hoc test with Bonferroni adjustment.

Results: The highest growth inhibition zone was obtained for carrot extract at a concentration of 500 mg/ml for C. glabrata and C. tropicalis. The MFC of carrot extract on Candida species was 62.5 mg/ml for C. albicans, C. glabrata, and C. parapsilosis, and 125 mg/ml for C. tropicalis. The MFC of carrot extract on Candida species was 125 mg/ml for C. albicans, C. glabrata, and C. parapsilosis, and 250 mg/ml for C. tropicalis.

Conclusion: The present study can be the starting point for research activities in this direction and promises new therapies based on the use of carotenoids.

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胡萝卜类胡萝卜素对念珠菌的抑菌作用。

背景:念珠菌病是由念珠菌引起的严重的妇女健康问题，尤其是白色念珠菌。本研究研究了胡萝卜提取物中类胡萝卜素对白色念珠菌ATCC1677、光滑念珠菌CBS2175、假丝酵母菌ATCC2195、热带念珠菌CBS94等念珠菌的影响。方法:采用描述性研究方法，于2012年12月在某胡萝卜种植场地制备胡萝卜植株，对其性状进行测定。从胡萝卜中提取类胡萝卜素，测定了不同念珠菌对胡萝卜提取物中类胡萝卜素的敏感性。并采用宏稀释法测定了各提取物的最小抑菌浓度和最小致死浓度。最后，采用SPSS软件进行Kruskal-Wallis检验和Mann-Whitney事后检验，并进行Bonferroni调整。结果:胡萝卜提取物浓度为500 mg/ml时，对光棘和热带棘的生长抑制带最大;胡萝卜提取物对白色念珠菌、光秃念珠菌和副念珠菌的MFC为62.5 mg/ml，对热带念珠菌的MFC为125 mg/ml。胡萝卜提取物对白色念珠菌、光秃念珠菌和副念珠菌的MFC为125 mg/ml，对热带念珠菌的MFC为250 mg/ml。结论:本研究为这一方向的研究提供了一个起点，并为基于类胡萝卜素的新疗法提供了希望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current drug discovery technologies Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

CiteScore

3.70

自引率

0.00%

发文量

期刊介绍： Due to the plethora of new approaches being used in modern drug discovery by the pharmaceutical industry, Current Drug Discovery Technologies has been established to provide comprehensive overviews of all the major modern techniques and technologies used in drug design and discovery. The journal is the forum for publishing both original research papers and reviews describing novel approaches and cutting edge technologies used in all stages of drug discovery. The journal addresses the multidimensional challenges of drug discovery science including integration issues of the drug discovery process.