Prevalence of Thyroid Peroxidase and Thyroglobulin Autoantibodies in the Swedish Population.

IF 1.6 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM Experimental and Clinical Endocrinology & Diabetes Pub Date : 2023-09-01 DOI:10.1055/a-2096-9641
Neele Bergemann, Berglind Jonsdottir, Anna-Lena Nilsson, Mikael Lantz, Alexander Lind
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Abstract

Autoimmune thyroid disease (AITD) may be detected prior to clinical symptoms through the presence of autoantibodies against thyroid peroxidase (TPOab), thyroglobulin (TGab), or both.The present study aimed to develop a novel radiobinding assay (RBA) for TPOab and to determine the prevalence of TPOab and TGab in the Swedish population.Patient samples from 27 newly diagnosed Graves' disease patients in longitudinal follow-up and 124 AITD autoantibody-positive children in prospective follow-up for increased risk of type 1 diabetes were included to validate the novel RBA for TPO. The results of RBA were compared with those obtained by commercial radioimmunoassay (RIA) and electrochemiluminescence (ECL). Furthermore, 476 serum samples from adult blood donors and 297 from 13-year-old school children were analyzed for the presence of TPOab and TGab.Receiver operating characteristics analysis for the novel TPOab resulted in an area under curve (AUC) value of 0.82 (p<0.0001), a sensitivity of 77.8%, and a specificity of 91.9% in adult blood donors, and an AUC value of 0.70 (p<0.0001), a sensitivity of 53.2% and a specificity of 95.3% in the 13-year-old school children, respectively. TPOab levels in RBA correlated with both ECL (r=0.8950, p<0.0001) and RIA (r=0.9295, p<0.0001). The prevalence of TPOab and TGab was 6.3% and 7.6% in adult blood donors and 2.9 and 3.7% in 13-year-old school children.In conclusion, a novel RBA for the determination of TPOab was developed and validated with current methodologies. This study also reports an increasing prevalence of thyroid autoantibodies from adolescence to adulthood.

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瑞典人群中甲状腺过氧化物酶和甲状腺球蛋白自身抗体的患病率。
自身免疫性甲状腺疾病(AITD)可以通过抗甲状腺过氧化物酶(TPOab)、甲状腺球蛋白(TGab)或两者的自身抗体在临床症状出现之前检测到。本研究旨在开发一种新的TPOab放射性结合试验(RBA),并确定瑞典人群中TPOab和TGab的患病率。纵向随访的27例新诊断的Graves病患者和前瞻性随访的124例AITD自身抗体阳性的1型糖尿病风险增加的儿童样本被纳入TPO的新型RBA验证。将RBA的结果与商业放射免疫测定法(RIA)和电化学发光法(ECL)的结果进行比较。此外,对476名成人献血者和297名13岁学龄儿童的血清样本进行了TPOab和TGab的分析。新型TPOab的受试者工作特性分析结果显示,曲线下面积(AUC)值为0.82 (p
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来源期刊
CiteScore
4.10
自引率
5.60%
发文量
72
审稿时长
3 months
期刊介绍: Publishing outstanding articles from all fields of endocrinology and diabetology, from molecular biology to clinical research, this journal is a brilliant resource. Since being published in English in 1983, the popularity of this journal has grown steadily, reflecting the importance of this publication within its field. Original contributions and short communications appear in each issue along with reviews addressing current topics. In addition, supplementary issues are published each year presenting abstracts or proceedings of national and international scientific meetings. The journal was initially published in German and is still the oldest endocrinological periodical in the German-language market!
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