Obstructive sleep apnoea and type 1 diabetes mellitus: A neglected relationship?

IF 1.6 4区医学 Q4 ENDOCRINOLOGY & METABOLISM Experimental and Clinical Endocrinology & Diabetes Pub Date : 2024-09-12 DOI:10.1055/a-2414-5487

Theodoros Panou,Konstantinos Roukas,Konstantina Chadia,Evangelia Nena,Evanthia Gouveri,Nikolaos Papanas,Paschalis Steiropoulos

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Abstract

Obstructive sleep apnoea (OSA) is regarded as a major health condition, progressively affecting an increased number of people around the world. The interplay between OSA and type 2 diabetes mellitus (T2DM) has been extensively studied. However, little is known on the relationship between OSA and type 1 diabetes mellitus (T1DM). This review provides an insight into the prevalence of OSA in T1DM and its relationship with diabetic complications. Studies have hitherto yielded contradictory results on the occurrence of OSA in T1DM. Indeed, the risk of OSA in T1DM has ranged from 1 in 10 T1DM subjects to more than 1 in 2 T1DM subjects. This high occurrence was confirmed both by objective polysomnography and by widely used subjective questionnaires. Multiple studies revealed the important correlation between OSA and the diabetes complications. Both microvascular (nephropathy, neuropathy and retinopathy) and macrovascular complications appear to be associated with OSA occurrence, although some associations were not significant due to inadequate data. In conclusion, T1DM subjects carry higher risk of OSA, which may be undiagnosed. Additional studies are needed to clarify the exact correlation between the 2 conditions.

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阻塞性睡眠呼吸暂停与 1 型糖尿病：被忽视的关系？

阻塞性睡眠呼吸暂停（OSA）被认为是一种主要的健康问题，逐渐影响着全世界越来越多的人。人们对 OSA 与 2 型糖尿病（T2DM）之间的相互影响进行了广泛研究。然而，人们对 OSA 与 1 型糖尿病（T1DM）之间的关系知之甚少。本综述深入探讨了 OSA 在 T1DM 中的发病率及其与糖尿病并发症的关系。迄今为止，关于 T1DM 中 OSA 发生率的研究结果相互矛盾。事实上，T1DM 患者发生 OSA 的风险从十分之一到超过二分之一不等。客观的多导睡眠图和广泛使用的主观问卷都证实了这种高发生率。多项研究揭示了 OSA 与糖尿病并发症之间的重要关联。微血管并发症（肾病、神经病变和视网膜病变）和大血管并发症似乎都与 OSA 的发生有关，尽管由于数据不足，有些关联并不显著。总之，T1DM 患者罹患 OSA 的风险较高，而且可能未被诊断出来。要明确这两种疾病之间的确切相关性，还需要进行更多的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Experimental and Clinical Endocrinology & Diabetes 医学-内分泌学与代谢

CiteScore

4.10

自引率

5.60%

发文量

审稿时长

3 months

期刊介绍： Publishing outstanding articles from all fields of endocrinology and diabetology, from molecular biology to clinical research, this journal is a brilliant resource. Since being published in English in 1983, the popularity of this journal has grown steadily, reflecting the importance of this publication within its field. Original contributions and short communications appear in each issue along with reviews addressing current topics. In addition, supplementary issues are published each year presenting abstracts or proceedings of national and international scientific meetings. The journal was initially published in German and is still the oldest endocrinological periodical in the German-language market!