Age at Menarche, Menopause Status and Metabolic Syndrome and its Components: Findings from the Henan Rural Cohort Study.

IF 1.6 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM Experimental and Clinical Endocrinology & Diabetes Pub Date : 2023-09-01 DOI:10.1055/a-2095-2074
Xueyan Wu, Du Zhen, Xiaotian Liu, Wei Liao, Xiaokang Dong, Jing Yang, Bing Zhao, Chongjian Wang
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Abstract

Introduction: To evaluate the effect of age at menarche on metabolic syndrome (Mets) and its components and explore the impact of menopause status on the association between age at menarche and Mets in rural Chinese women.

Methods: This cross-sectional study enrolled 23382 women from the Henan Rural Cohort study. The relationship between age at menarche and Mets was assessed using logistic regression and restricted cubic spline. Interaction plots were used to describe interactive effects of age at menarche and menopause status on Mets.

Results: Age at menarche was inversely associated with the risk of Mets with the adjusted OR of 1.16, 0.98, 1.00, 0.82, and 0.77, respectively, for those with age at menarche≤13, 14, 15-16 (reference), 17, and≥18 years. Each year of delay in menarche age correlated with a 6.2% (P<0.001) lower risk of Mets. Among the components of Mets, an inverse association was observed between age at menarche and central obesity (OR (95% CI): 0.92 (0.90, 0.94)), abnormal FPG (OR (95% CI): 0.96 (0.94, 0.97)), abnormal BP (OR (95% CI): 0.967 (0.95, 0.98)), abnormal TG (OR (95% CI): 0.96 (0.94, 0.97)), and abnormal HDL-C (OR (95% CI): 0.96 (0.95, 0.98)). Significant interactions were discovered between age at menarche, menopause status, and the risk of Mets, central obesity, abnormal FPG, abnormal BP, and abnormal TG (all P interaction<0.001). The adverse effect of menopausal status on Mets, central obesity, abnormal FPG, abnormal BP, and abnormal TG decreased with delayed age at menarche.

Conclusions: Later menarche was associated with a lower risk of Mets. More importantly, the deleterious effect of menopause status on Mets decreased with the increase in age at menarche.

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月经初潮年龄、绝经状态与代谢综合征及其组成:来自河南农村队列研究的结果。
前言:评价初潮年龄对中国农村妇女代谢综合征(Mets)及其组成的影响,探讨绝经状态对初潮年龄与Mets相关性的影响。方法:本横断面研究纳入了来自河南农村队列研究的23382名妇女。初潮年龄与Mets之间的关系采用logistic回归和限制性三次样条进行评估。相互作用图用于描述初潮年龄和绝经状态对Mets的相互作用效应。结果:初潮年龄与met风险呈负相关,初潮年龄≤13岁、14岁、15-16岁(参考文献)、17岁和≥18岁的患者的调整OR分别为1.16、0.98、1.00、0.82和0.77。月经初潮年龄每推迟一年与6.2%的PP相互作用相关。结论:月经初潮较晚与较低的met风险相关。更重要的是,绝经状态对Mets的有害影响随着月经初潮年龄的增加而减少。
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来源期刊
CiteScore
4.10
自引率
5.60%
发文量
72
审稿时长
3 months
期刊介绍: Publishing outstanding articles from all fields of endocrinology and diabetology, from molecular biology to clinical research, this journal is a brilliant resource. Since being published in English in 1983, the popularity of this journal has grown steadily, reflecting the importance of this publication within its field. Original contributions and short communications appear in each issue along with reviews addressing current topics. In addition, supplementary issues are published each year presenting abstracts or proceedings of national and international scientific meetings. The journal was initially published in German and is still the oldest endocrinological periodical in the German-language market!
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