The effect of medical biodegradable magnesium alloy in vivo degradation and bone response in a rat femur model with long-term fixation.

IF 1 4区 医学 Q4 ENGINEERING, BIOMEDICAL Bio-medical materials and engineering Pub Date : 2023-01-01 DOI:10.3233/BME-222514
Ying Zhang, Haijian Wang, Takashi Kumazawa, Dongying Ju
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Abstract

Background: It is of great significance to understand the effect of the different corrosion behaviors of magnesium (Mg) alloys manufactured using different casting methods and implanted with different methods on the long-term implantation to expand the application of Mg-based biomedical implants.

Objective: The effects of four different casting and rolling speeds on the microstructure of an Mg-rare earth (Mg-Re) alloy were analyzed using electron backscatter diffraction (EBSD).

Method: Four Mg alloys were obtained using vertical two-roll casting (TRC) at 10 m/min, 16 m/min, 24 m/min, and 30 m/min, and their microstructure, corrosion behavior and bone reaction in vivo were studied.

Results: The corrosion resistance of the alloy increases with an increase in casting speed and finer grain size of the cast-rolled parts. The Mg-Re alloys with TRC-10 m/min and TRC-30 m/min were selected for animal experiments. The two Mg alloys were made into metal rods and inserted into the rat femur to simulate the effect of Mg-Re on femoral healing under an injury condition. The rods were implanted for a long time to judge the effects of the Mg-Re alloy on the body. The TRC-30 m/min implants obtained highly mature new bone tissue in the case of bone injury.

Conclusion: The in vivo experiments showed that the corrosion resistance of the TRC-30 m/min implant was better than that of the TRC-10 m/min implant. After 32 weeks of implantation, there were no pathological changes in the liver, heart, or kidney of rats in the TRC-30 m/min group, and the cell structure was normal.

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医用可生物降解镁合金对大鼠股骨长期固定模型体内降解及骨反应的影响。
背景:了解不同铸造方法和不同植入方式制备的镁合金的不同腐蚀行为对长期植入的影响,对扩大镁基生物医学植入物的应用具有重要意义。目的:利用电子背散射衍射(EBSD)分析四种不同铸造和轧制速度对mg -稀土(Mg-Re)合金显微组织的影响。方法:采用垂直双辊铸造(TRC)工艺,以10 m/min、16 m/min、24 m/min和30 m/min的速度制备4种Mg合金,研究其显微组织、腐蚀行为和体内骨反应。结果:合金的耐蚀性随着铸造速度的提高和铸轧件晶粒的细化而提高。动物实验选用TRC-10 m/min和TRC-30 m/min的Mg-Re合金。将两种镁合金制成金属棒,植入大鼠股骨,模拟Mg- re对损伤条件下股骨愈合的影响。长时间植入棒体,以判断Mg-Re合金对机体的影响。在骨损伤情况下,TRC-30 m/min种植体获得高度成熟的新骨组织。结论:体内实验表明,TRC-30 m/min种植体的耐蚀性优于TRC-10 m/min种植体。植入32周后,TRC-30 m/min组大鼠肝脏、心脏、肾脏均未见病理改变,细胞结构正常。
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来源期刊
Bio-medical materials and engineering
Bio-medical materials and engineering 工程技术-材料科学:生物材料
CiteScore
1.80
自引率
0.00%
发文量
73
审稿时长
6 months
期刊介绍: The aim of Bio-Medical Materials and Engineering is to promote the welfare of humans and to help them keep healthy. This international journal is an interdisciplinary journal that publishes original research papers, review articles and brief notes on materials and engineering for biological and medical systems. Articles in this peer-reviewed journal cover a wide range of topics, including, but not limited to: Engineering as applied to improving diagnosis, therapy, and prevention of disease and injury, and better substitutes for damaged or disabled human organs; Studies of biomaterial interactions with the human body, bio-compatibility, interfacial and interaction problems; Biomechanical behavior under biological and/or medical conditions; Mechanical and biological properties of membrane biomaterials; Cellular and tissue engineering, physiological, biophysical, biochemical bioengineering aspects; Implant failure fields and degradation of implants. Biomimetics engineering and materials including system analysis as supporter for aged people and as rehabilitation; Bioengineering and materials technology as applied to the decontamination against environmental problems; Biosensors, bioreactors, bioprocess instrumentation and control system; Application to food engineering; Standardization problems on biomaterials and related products; Assessment of reliability and safety of biomedical materials and man-machine systems; and Product liability of biomaterials and related products.
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