Preparation, Characterization and Drug Delivery Research of γ-Polyglutamic Acid Nanoparticles: A Review.

IF 2.8 4区医学 Q2 PHARMACOLOGY & PHARMACY Current drug delivery Pub Date : 2024-01-01 DOI:10.2174/1567201820666230102140450

Zhihan Liu, Yan He, Xia Ma

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Abstract

γ-Polyglutamic acid is a kind of biomaterial and environmentally friendly polymer material with the characteristics of water solubility and good biocompatibility. It has a wide range of applications in medicine, food, cosmetics and other fields. This article reviews the preparation, characterization and medical applications of γ-polyglutamic acid nanoparticles. Nanoparticles prepared by using γ- polyglutamic acid not only had the traditional advantages of enhancing drug stability and slow-release effect, but also were simple to prepare without any biological toxicity. The current methods of nanoparticle preparation mainly include the ion gel method and solvent exchange method, which use the total electrostatic force, van der Waals force, hydrophobic interaction force and hydrogen bond force between molecules to embed materials with different characteristics. At present, there are more and more studies on the use of γ-polyglutamic acid to encapsulate drugs, and the research on the mechanism of its encapsulation and sustained release has gradually matured. The development and application of polyglutamic acid nanoparticles have broad prospects.

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γ-聚谷氨酸纳米颗粒的制备、表征和给药研究：综述

γ-聚谷氨酸是一种生物材料和环保型高分子材料，具有水溶性和良好的生物相容性。它在医药、食品、化妆品等领域有着广泛的应用。本文综述了γ-聚谷氨酸纳米粒子的制备、表征和医学应用。利用γ-聚谷氨酸制备的纳米颗粒不仅具有增强药物稳定性和缓释效果的传统优势，而且制备简单，无生物毒性。目前制备纳米粒子的方法主要有离子凝胶法和溶剂交换法，利用分子间的总静电力、范德华力、疏水作用力和氢键力来包埋不同特性的材料。目前，利用γ-聚谷氨酸包封药物的研究越来越多，对其包封和缓释机理的研究也逐渐成熟。聚谷氨酸纳米颗粒的开发和应用具有广阔的前景。

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来源期刊

Current drug delivery PHARMACOLOGY & PHARMACY-

CiteScore

5.10

自引率

4.20%

发文量

170

期刊介绍： Current Drug Delivery aims to publish peer-reviewed articles, research articles, short and in-depth reviews, and drug clinical trials studies in the rapidly developing field of drug delivery. Modern drug research aims to build delivery properties of a drug at the design phase, however in many cases this idea cannot be met and the development of delivery systems becomes as important as the development of the drugs themselves. The journal aims to cover the latest outstanding developments in drug and vaccine delivery employing physical, physico-chemical and chemical methods. The drugs include a wide range of bioactive compounds from simple pharmaceuticals to peptides, proteins, nucleotides, nucleosides and sugars. The journal will also report progress in the fields of transport routes and mechanisms including efflux proteins and multi-drug resistance. The journal is essential for all pharmaceutical scientists involved in drug design, development and delivery.