Determination of the Re-188 Calibration Number for the Capintec CRC- 25PET Dose Calibrator.

IF 1.5 4区医学 Q3 PHARMACOLOGY & PHARMACY Current radiopharmaceuticals Pub Date : 2023-01-01 DOI:10.2174/1874471016666230502140224

Mitchell Ashley Klenner, Aron Poole

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Abstract

Background: During the development of novel Re-188 radiopharmaceuticals, it was discovered that no calibration settings were published to calibrate Re-188 on the Capintec CRC-25PET dose calibrator.

Methods: Sodium [¹⁸⁸Re]perrhenate was eluted from an OncoBeta ¹⁸⁸W/¹⁸⁸Re generator to measure activity on a Capintec CRC-25R dose calibrator using established dose calibrator settings provided by the manufacturer. The eluent was then used to tune the calibra on settings on a Capintec CRC-25PET dose calibrator, accounting for geometry. Radionuclidic purity of the [¹⁸⁸Re]perrhenate source was verified via gamma spectroscopy.

Results: The calibrator number for Re-188 was determined to be 469 x 10 for the Capintec CRC-25PET dose calibrator, which differed from the manufacturer provided calibra on number of 496 x 10 for the Capintec CRC-25R dose calibra on model. W-188 breakthrough was characterised as < 0.01%.

Conclusion: This previously unreported calibration number can be used to determine the activity of Re- 188 labelled radiopharmaceuticals using the Capintec CRC-25PET dose calibrator model.

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Capintec CRC- 25PET剂量校准器Re-188校准号的确定。

背景:在新型Re-188放射性药物的开发过程中，发现Capintec CRC-25PET剂量校准器上没有发布校准设置来校准Re-188。方法:从OncoBeta 188W/188Re发生器中洗脱过透酸钠[188Re]，在Capintec CRC-25R剂量校准器上使用制造商提供的剂量校准器设置测量活性。然后使用该洗脱液调整Capintec CRC-25PET剂量校准器上的刻度设置，考虑几何形状。通过伽玛谱法验证了[188Re]过铼酸盐源的放射性核素纯度。结果:Capintec CRC-25PET剂量校准器的Re-188校准器编号为469 × 10，不同于制造商提供的型号Capintec CRC-25R剂量校准器编号为496 × 10。W-188突破特征为< 0.01%。结论:此先前未报道的校准数可用于使用Capintec CRC-25PET剂量校准器模型确定Re- 188标记的放射性药物的活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current radiopharmaceuticals PHARMACOLOGY & PHARMACY-

CiteScore

3.20

自引率

4.30%

发文量