External ureteric stent versus internal double J stent in kidney transplantation: a retrospective analysis on the incidence of urological complications and urinary tract infections.

Ietje T Hazenberg, Stephanie J M Middelkoop, Anoek A E de Joode, Juliette D Rabbeljee, Robert A Pol, Benjamin H J Doornweerd, Jan-Stephan F Sanders, Coen A Stegeman
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Abstract

Introduction: Urologic complications (UCs) and urinary tract infections (UTIs) are common after kidney transplantation. Intraoperative stent placement at the vesicoureteric anastomosis reduces UC risk, but increases UTI risk.

Methods: In 2014 our stenting protocol changed from external ureteric stent (ES) to internal double J stent (DJ). We retrospectively studied the occurrence of UCs and UTIs in relation to ES or DJ in 697 kidney recipients.

Methods: An ES was used in 403 patients (57.8%), in 294 (42.2%) a DJ. ES was removed 7-12 days and DJ 3-4 weeks post-operative. Induction immunosuppression was the same in both groups. Primary outcomes at 6 months follow-up were UC (urinary leakage/ureter stenosis) and UTI; they were related to stenting procedure and clinical and transplant characteristics. The incidence of UCs was similar for ES (8.4%) and DJ (6.8%), p=0.389. ES use was a significant risk factor for UTI (OR 1.69 (1.15-2.50), p=0.008). Post-transplant hospitalization was significantly shorter in the DJ group. Despite more acute rejection episodes with ES (ES/DJ: 16.4%/6.1%, p<0.001), no clinical relevant differences in graft outcomes existed.

Discussion: A DJ is, compared to ES, associated with a lower incidence of UTIs and comparable occurrence of UCs and is therefore the preferred technique for stenting the vesicoureteric anastomosis.

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输尿管外支架与肾移植内双J支架:泌尿系统并发症和尿路感染发生率的回顾性分析。
肾移植术后泌尿系统并发症(UCs)和尿路感染(uti)很常见。术中膀胱输尿管吻合处放置支架可降低UC风险,但增加UTI风险。方法:2014年,我们将输尿管外支架(ES)改为输尿管内双J型支架(DJ)。我们回顾性研究了697例肾受者与ES或DJ相关的UCs和UTIs的发生情况。方法:403例(57.8%)采用ES, 294例(42.2%)采用DJ。术后7-12天切除ES, 3-4周切除DJ。两组诱导免疫抑制相同。6个月随访时的主要结局为UC(尿漏/输尿管狭窄)和UTI;它们与支架植入术、临床和移植特征有关。ES(8.4%)和DJ(6.8%)的UCs发生率相似,p=0.389。使用ES是UTI的重要危险因素(OR 1.69 (1.15-2.50), p=0.008)。DJ组移植后住院时间明显缩短。尽管ES的急性排斥反应发生率更高(ES/DJ: 16.4%/6.1%),但与ES相比,DJ与尿路感染发生率较低和UCs发生率相当相关,因此是膀胱输尿管吻合术支架置入的首选技术。
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