Herbal Medicines for Idiopathic Male Infertility: A Systematic Review.

Q3 Pharmacology, Toxicology and Pharmaceutics Current drug discovery technologies Pub Date : 2022-01-01 DOI:10.2174/1570163819666220820122101

Mohammad Ahmadian, Roshanak Salari, Mohammad Reza Noras, Hamid Reza Bahrami-Taghanaki

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引用次数: 1

Abstract

Background: Various medications, surgeries, and assisted reproductive techniques are used to treat male infertility, but the high cost and low effectiveness have made these methods unpopular. The use of herbal medicines such as Withania somnifera, Ceratonia siliqua, Nigella sativa and Alpinia officinarum for the treatment of male infertility has become highly popular in recent years.

Objective: We conducted this systematic review to evaluate the recent scientific evidence regarding herbal medicines used to treat idiopathic male infertility (IMI).

Methods: Online literature resources were checked using different search engines, including ISI, Web of Knowledge, Medline, PubMed, Scopus, and Google Scholar. Date restrictions were applied to 2020, and the publication language was restricted to English and Persian. The risk of bias was evaluated using the Cochrane method.

Results: Out of 851 articles, 14 trials with 1218 participants were included. Of the 15 plants and medicinal products introduced in the selected studies, 12 cases were effective in treating male infertility. Each of these plants or products affects specific components of male fertility for which various mechanisms were mentioned, but most of them had antioxidant effects. No serious side effects were reported.

Conclusion: Whitania somnifera roots, Alpinia officinarum, Nigella sativa seeds, Tomato, and Ceratonia siliqua and the formulation of Xperm, PHF, Churna Ratnam, Svaguptadi Churna, Y virilin capsule, manix capsule, and Tradafertil tablet revealed successful outcomes in treatment of idiopathic male infertility.

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草药治疗特发性男性不育症:系统综述。

背景:各种药物、手术和辅助生殖技术被用于治疗男性不育症，但这些方法的高成本和低效果使这些方法不受欢迎。近年来，人们普遍使用一些草药治疗男性不育症，如Withania somnifera、Ceratonia siliqua、Nigella sativa和Alpinia officinarum。目的:我们进行了这一系统综述，以评估最近关于草药治疗特发性男性不育症(IMI)的科学证据。方法:利用ISI、Web of Knowledge、Medline、PubMed、Scopus、Google Scholar等搜索引擎对网络文献资源进行检索。日期限制适用于2020年，出版语言仅限于英语和波斯语。采用Cochrane方法评估偏倚风险。结果:在851篇文章中，纳入了14项试验，1218名受试者。在选定的研究中介绍的15种植物和药品中，有12例对治疗男性不育症有效。这些植物或产品中的每一种都影响男性生育能力的特定成分，其中各种机制被提到，但大多数都具有抗氧化作用。没有严重的副作用报告。结论:黑穗槐根、高山麻、黑穗槐种子、番茄、白屈菌及Xperm、PHF、chillna Ratnam、saguptadi Churna、yvirilin胶囊、manix胶囊、Tradafertil片治疗特发男性不育症疗效显著。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current drug discovery technologies Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

CiteScore

3.70

自引率

0.00%

发文量

期刊介绍： Due to the plethora of new approaches being used in modern drug discovery by the pharmaceutical industry, Current Drug Discovery Technologies has been established to provide comprehensive overviews of all the major modern techniques and technologies used in drug design and discovery. The journal is the forum for publishing both original research papers and reviews describing novel approaches and cutting edge technologies used in all stages of drug discovery. The journal addresses the multidimensional challenges of drug discovery science including integration issues of the drug discovery process.