Research Progress of Novel Drug Delivery Systems of Chinese Medicine Monomers based on Natural Silk Fibroin: A Mini-Review.

IF 2.8 4区医学 Q2 PHARMACOLOGY & PHARMACY Current drug delivery Pub Date : 2023-01-01 DOI:10.2174/1567201819666220413111439

Bin Yu, Zheng Sun, Xuecheng Li, Aimei Qv, Muhammad Sohail, Yanli Li, Hui Xu, Ping Xiang

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引用次数: 2

Abstract

Traditional Chinese medicine (TCM) has a good curative effect, but its disadvantages include complex components, poor drug stability, potential drug interaction, etc. Therefore, it is particularly important to construct a novel drug delivery system that can load Chinese medicine monomers to solve this problem. Silk fibroin is a kind of natural polymer material with unique properties. It can be used as a carrier material to load Chinese medicine monomers to prepare novel drug delivery systems that significantly affect treating diseases without toxic and side effects. However, there is still a lack of a review on silk fibroin as a carrier material to load Chinese medicine monomers to explore and analyze the current research results and progress. Here, our article focuses on the in-depth excavation and analysis of the recent research on novel drug delivery systems prepared by silk fibroin and TCM monomers. Besides, the characteristics, existing problems, and prospects of silk fibroin are discussed and explained. It is hoped that this research can provide a reference and basis for the modernization of TCM, the design of novel drug delivery systems, the research and development of new drugs in the future, and contribute to the innovation of silk protein.

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基于天然丝素蛋白的新型中药单体给药系统研究进展

中药具有良好的疗效，但存在成分复杂、药物稳定性差、药物相互作用等缺点。因此，构建一种能够装载中药单体的新型给药系统来解决这一问题就显得尤为重要。丝素是一种具有独特性能的天然高分子材料。可作为载药中药单体的载体材料，制备对治疗疾病有显著影响且无毒副作用的新型给药系统。然而，目前尚缺乏对丝素蛋白作为载体材料装载中药单体的综述，以探索和分析目前的研究成果和进展。本文重点对丝素蛋白与中药单体制备的新型给药体系的最新研究进行了深入的挖掘和分析。并对丝素的特点、存在的问题及发展前景进行了讨论和说明。希望本研究能为今后中医药现代化、新型给药系统设计、新药研发提供参考和依据，并为丝蛋白的创新做出贡献。

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来源期刊

Current drug delivery PHARMACOLOGY & PHARMACY-

CiteScore

5.10

自引率

4.20%

发文量

170

期刊介绍： Current Drug Delivery aims to publish peer-reviewed articles, research articles, short and in-depth reviews, and drug clinical trials studies in the rapidly developing field of drug delivery. Modern drug research aims to build delivery properties of a drug at the design phase, however in many cases this idea cannot be met and the development of delivery systems becomes as important as the development of the drugs themselves. The journal aims to cover the latest outstanding developments in drug and vaccine delivery employing physical, physico-chemical and chemical methods. The drugs include a wide range of bioactive compounds from simple pharmaceuticals to peptides, proteins, nucleotides, nucleosides and sugars. The journal will also report progress in the fields of transport routes and mechanisms including efflux proteins and multi-drug resistance. The journal is essential for all pharmaceutical scientists involved in drug design, development and delivery.