Lead Optimization of Nerve-Specific Fluorophores for Image-Guided Nerve Sparing Surgical Procedures.

Connor W Barth, Lei G Wang, Antonio Montano, Alexander L Antaris, Alwin Klaassen, Jonathan Sorger, Darcy A Kerr, Eric R Henderson, Adam W G Alani, Summer L Gibbs
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Abstract

Nerve damage is a major complication of surgery, causing pain and loss of function. We have identified novel near-infrared nerve-specific fluorophores that provide excellent nerve contrast with the ability to identify buried nerve tissue.

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图像引导神经保留外科手术中神经特异性荧光团的先导优化。
神经损伤是手术的主要并发症,会引起疼痛和功能丧失。我们已经确定了新的近红外神经特异性荧光团,它提供了极好的神经对比,能够识别埋藏的神经组织。
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Lead Optimization of Nerve-Specific Fluorophores for Image-Guided Nerve Sparing Surgical Procedures. AlliGator: A Phasor Computational Platform for Fast in vivo Lifetime Analysis.
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