Sudarshan Ganesh, Mariana Moreno, Jianfeng Liu, Marcial Gonzalez, Zoltan Nagy, Gintaras Reklaitis
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Abstract
The progress in the mechanistic understanding of the unit operations and the availability of multiple sensor technologies enable the inline implementation of data reconciliation and gross error detection methods in continuous pharmaceutical manufacturing. In this work, we demonstrate the benefits of accurate real-time monitoring of the process state in a continuous tableting process, with case studies representative of common situations in pilot-plant or manufacturing line implementation.
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