Comparative Study of New Biomarkers in Iraqi DM2 with and without Complications.

IF 1.6 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Reports of Biochemistry and Molecular Biology Pub Date : 2022-10-01 DOI:10.52547/rbmb.11.3.400

Husam Salman Jasim, Anwar Farooq Altaie, Warkaa Touma Saloum, Ali Hussein Ali

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Abstract

Background: Recent research indicates that persistent inflammatory responses may contribute to the rise of diabetic nephropathy (DN) and diabetic cardiovascular disease (DCVD) in type 2 diabetes mellitus patients (DM2). Numerous molecules associated with inflammation and angiogenesis have been implicated in the development and progression of DN and DCVD, respectively.

Methods: The subjects were separated into five groups: healthy controls (n= 25), type 2 diabetes mellitus patients (n= 30), type 2 diabetes mellitus patients with nephropathy DN (n= 30), and type 2 diabetes mellitus patients with cardiovascular disease DCVD (n= 30). The blood levels of irisin, IL-8, HbA1C, urea, and creatinine were determined.

Results: In current study there was high significant increased irisin levels (p< 0.001) in DN patients than other groups and a high significant decreased IL-8 level in DCVD.

Discussion: Serum IL-8 and irisin levels may serve as early indicators of DM2 problems (DN, DCVD).

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伊拉克DM2伴与无并发症新生物标志物的比较研究。

背景:最近的研究表明，持续的炎症反应可能导致2型糖尿病(DM2)患者糖尿病肾病(DN)和糖尿病心血管疾病(DCVD)的增加。许多与炎症和血管生成相关的分子分别与DN和DCVD的发生和进展有关。方法:将受试者分为5组:健康对照组(n= 25)、2型糖尿病患者(n= 30)、2型糖尿病合并肾病DN (n= 30)、2型糖尿病合并心血管疾病DCVD (n= 30)。测定血中鸢尾素、白介素-8、糖化血红蛋白、尿素和肌酐水平。结果:本研究中，DN患者鸢尾素水平显著高于其他组(p< 0.001)，而DCVD患者IL-8水平显著低于其他组。讨论:血清IL-8和鸢尾素水平可作为DM2问题(DN, DCVD)的早期指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reports of Biochemistry and Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

2.80

自引率

23.50%

发文量

审稿时长

10 weeks

期刊介绍： The Reports of Biochemistry & Molecular Biology (RBMB) is the official journal of the Varastegan Institute for Medical Sciences and is dedicated to furthering international exchange of medical and biomedical science experience and opinion and a platform for worldwide dissemination. The RBMB is a medical journal that gives special emphasis to biochemical research and molecular biology studies. The Journal invites original and review articles, short communications, reports on experiments and clinical cases, and case reports containing new insights into any aspect of biochemistry and molecular biology that are not published or being considered for publication elsewhere. Publications are accepted in the form of reports of original research, brief communications, case reports, structured reviews, editorials, commentaries, views and perspectives, letters to authors, book reviews, resources, news, and event agenda.