Lowered oxygen saturation and increased body temperature in acute COVID-19 largely predict chronic fatigue syndrome and affective symptoms due to Long COVID: A precision nomothetic approach.

IF 3.8 4区 医学 Q1 Medicine Acta Neuropsychiatrica Pub Date : 2023-04-01 DOI:10.1017/neu.2022.21
Dhurgham Shihab Al-Hadrawi, Haneen Tahseen Al-Rubaye, Abbas F Almulla, Hussein Kadhem Al-Hakeim, Michael Maes
{"title":"Lowered oxygen saturation and increased body temperature in acute COVID-19 largely predict chronic fatigue syndrome and affective symptoms due to Long COVID: A precision nomothetic approach.","authors":"Dhurgham Shihab Al-Hadrawi,&nbsp;Haneen Tahseen Al-Rubaye,&nbsp;Abbas F Almulla,&nbsp;Hussein Kadhem Al-Hakeim,&nbsp;Michael Maes","doi":"10.1017/neu.2022.21","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Long coronavirus disease 2019 (LC) is a chronic sequel of acute COVID-19. The exact pathophysiology of the affective, chronic fatigue and physiosomatic symptoms (labelled as \"physio-affective phenome\") of LC has remained elusive.</p><p><strong>Objective: </strong>The current study aims to delineate the effects of oxygen saturation (SpO2) and body temperature during the acute phase on the physio-affective phenome of LC.</p><p><strong>Method: </strong>We recruited 120 LC patients and 36 controls. For all participants, we assessed the lowest SpO2 and peak body temperature during acute COVID-19, and the Hamilton Depression and Anxiety Rating Scale (HAMD/HAMA) and Fibro Fatigue (FF) scales 3-4 months later.</p><p><strong>Results: </strong>Lowered SpO2 and increased body temperature during the acute phase and female sex predict 60.7% of the variance in the physio-affective phenome of LC. Using unsupervised learning techniques, we were able to delineate a new endophenotype class, which comprises around 26.7% of the LC patients and is characterised by very low SpO2 and very high body temperature, and depression, anxiety, chronic fatigue, and autonomic and gastro-intestinal symptoms scores. Single latent vectors could be extracted from both biomarkers, depression, anxiety and FF symptoms or from both biomarkers, insomnia, chronic fatigue, gastro-intestinal and autonomic symptoms.</p><p><strong>Conclusion: </strong>The newly constructed endophenotype class and pathway phenotypes indicate that the physio-affective phenome of LC is at least in part the consequence of the pathophysiology of acute COVID-19, namely the combined effects of lowered SpO2, increased body temperature and the associated immune-inflammatory processes and lung lesions.</p>","PeriodicalId":7066,"journal":{"name":"Acta Neuropsychiatrica","volume":"35 2","pages":"76-87"},"PeriodicalIF":3.8000,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Neuropsychiatrica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1017/neu.2022.21","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Long coronavirus disease 2019 (LC) is a chronic sequel of acute COVID-19. The exact pathophysiology of the affective, chronic fatigue and physiosomatic symptoms (labelled as "physio-affective phenome") of LC has remained elusive.

Objective: The current study aims to delineate the effects of oxygen saturation (SpO2) and body temperature during the acute phase on the physio-affective phenome of LC.

Method: We recruited 120 LC patients and 36 controls. For all participants, we assessed the lowest SpO2 and peak body temperature during acute COVID-19, and the Hamilton Depression and Anxiety Rating Scale (HAMD/HAMA) and Fibro Fatigue (FF) scales 3-4 months later.

Results: Lowered SpO2 and increased body temperature during the acute phase and female sex predict 60.7% of the variance in the physio-affective phenome of LC. Using unsupervised learning techniques, we were able to delineate a new endophenotype class, which comprises around 26.7% of the LC patients and is characterised by very low SpO2 and very high body temperature, and depression, anxiety, chronic fatigue, and autonomic and gastro-intestinal symptoms scores. Single latent vectors could be extracted from both biomarkers, depression, anxiety and FF symptoms or from both biomarkers, insomnia, chronic fatigue, gastro-intestinal and autonomic symptoms.

Conclusion: The newly constructed endophenotype class and pathway phenotypes indicate that the physio-affective phenome of LC is at least in part the consequence of the pathophysiology of acute COVID-19, namely the combined effects of lowered SpO2, increased body temperature and the associated immune-inflammatory processes and lung lesions.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
急性COVID-19患者血氧饱和度降低和体温升高在很大程度上预测长COVID导致的慢性疲劳综合征和情感性症状:一种精确的拟合方法。
背景:长冠状病毒病2019 (LC)是急性COVID-19的慢性后遗症。LC的情感、慢性疲劳和生理症状(标记为“生理-情感现象”)的确切病理生理学仍然难以捉摸。目的:探讨急性期血氧饱和度(SpO2)和体温对LC生理-情感现象的影响。方法:我们招募了120例LC患者和36例对照组。对于所有参与者,我们评估了急性COVID-19期间最低SpO2和最高体温,并在3-4个月后评估了汉密尔顿抑郁和焦虑评定量表(HAMD/HAMA)和纤维疲劳量表(FF)。结果:急性期SpO2降低、体温升高和女性预测了LC生理-情感表型变异的60.7%。使用无监督学习技术,我们能够描绘出一个新的内表型类别,它包括约26.7%的LC患者,其特征是非常低的SpO2和非常高的体温,抑郁,焦虑,慢性疲劳,自主神经和胃肠道症状评分。单一潜伏载体可以从生物标志物、抑郁、焦虑和FF症状中提取,也可以从生物标志物、失眠、慢性疲劳、胃肠道和自主神经症状中提取。结论:新构建的内表型类和通路表型表明,LC的生理-情感表型至少部分是急性COVID-19病理生理的结果,即SpO2降低、体温升高以及相关的免疫炎症过程和肺部病变的综合作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Acta Neuropsychiatrica
Acta Neuropsychiatrica 医学-精神病学
CiteScore
8.50
自引率
5.30%
发文量
30
审稿时长
6-12 weeks
期刊介绍: Acta Neuropsychiatrica is an international journal focussing on translational neuropsychiatry. It publishes high-quality original research papers and reviews. The Journal''s scope specifically highlights the pathway from discovery to clinical applications, healthcare and global health that can be viewed broadly as the spectrum of work that marks the pathway from discovery to global health.
期刊最新文献
Cannabidiol modulates contextual fear memory consolidation in animals with experimentally induced type-1 diabetes mellitus. Role of T and B lymphocyte cannabinoid type 1 and 2 receptors in major depression and suicidal behaviours. Cannabidiol negatively modulates adenosine A2A receptor functioning in living cells. The effects of cannabidiol on behavioural and oxidative stress parameters induced by prolonged haloperidol administration. Psychiatric sequelae after SARS-Cov-2 infection: trajectory, predictors and associations in a longitudinal Australian cohort.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1