Drug-eluting stent with rhombic-shape reservoirs for drug delivery

Yen-Ting Wang, Yi-Ping Wang, Tzu-Yuan Lin, Chien-Erh Lin, H. Hsiao
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引用次数: 3

Abstract

A novel drug-eluting stent with rhombic-shape drug reservoirs is proposed, aimed at providing smart drug delivery and longer fatigue life. By creating the rhombic-shape reservoirs, a stent could increase its total drug capacity and improves its stress distribution for fatigue life enhancement. Simulation results showed that the total drug capacity of our stent could be significantly increased without sacrificing its fatigue life. This is astonishing considering that the stent mechanical integrity could be deteriorated by creating channels on the stent structure.
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菱形储药库药物洗脱支架
提出了一种具有菱形药物储存库的新型药物洗脱支架,旨在提供智能药物传递和更长的疲劳寿命。通过创建菱形储层,可以增加支架的总药物容量,改善支架的应力分布,从而提高支架的疲劳寿命。仿真结果表明,在不牺牲支架疲劳寿命的前提下,可以显著提高支架的总容药能力。考虑到在支架结构上产生通道可能会破坏支架的机械完整性,这是令人惊讶的。
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