Study of electrogram organization and synchronization in paroxysmal and persistent/permanent atrial fibrillation

A. Alcaine, Angel Arenai, P. Laguna, J. P. Martínez
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Abstract

In this study, we measure and compare organization and synchronization of electrograms (EGM) obtained from patients with different types of diagnosed atrial fibrillation (AF). The studied database is composed of 70 patients admitted for ablation procedure and previously classified as paroxysmal or persistent/permanent AF. From those patients we analyzed bipolar EGM recordings during AF which were acquired using a circular catheter placed in the pulmonary veins. Results, which are given next as median (IQR), suggest that shorter (145.9 (27) ms vs. 161.3 (33.6) ms, p <; 0.01) and less stable AF cycle length (32.1 (36) ms vs. 7.2 (32.7) ms, p <; 0.01) is associated with persistent/permanent AF. Moreover, a significant reduction of the synchronization (0.35 (0.44) vs. 0.47 (0.51), p = 0.03) and linear relation (0.27 (0.40) vs. 0.36 (0.47), p = 0.01) between EGMs from antipodal electrodes of the same catheter has been found in persistent/permanent AF patients.
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阵发性和持续性/永久性房颤的电图组织与同步研究
在这项研究中,我们测量并比较了不同类型心房颤动(AF)患者的心电图(EGM)的组织和同步性。所研究的数据库由70例接受消融术的患者组成,这些患者以前被分类为阵发性或持续性/永久性房颤。我们分析了这些患者在房颤期间的双极EGM记录,这些记录是通过放置在肺静脉中的圆形导管获得的。结果中位数(IQR)显示较短(145.9 (27)ms vs. 161.3 (33.6) ms, p <;0.01)和更短的稳定AF周期长度(32.1 (36)ms vs. 7.2 (32.7) ms, p <;0.01)与持续性/永久性房颤相关。此外,在持续性/永久性房颤患者中,同一导管对跖电极的egm之间的同步性显著降低(0.35(0.44)对0.47 (0.51),p = 0.03),线性关系(0.27(0.40)对0.36 (0.47),p = 0.01)。
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