POSSIBILITIES OF DIAGNOSIS AND TREATMENT OF ACUTE AND CHRONIC BRAIN ISCHEMIA

Abstract

Aim: To study the formation of pathological brain systems and their transformation during treatment in patients with acute and chronic cerebral ischemia, using the method of quantitative EEG with wavelet analysis. Material and methods: In the period from 2016 to 2020, 120 people aged 40 to 68 years with CSI and IS were comprehensively examined in dynamics. Patients underwent quantitative EEG (qEEG) with wavelet analysis on days 1, 7, 14, 21, 28. In addition to the protocol, one group of patients received ethylmethyhydropyridoxine succinate. Results: The formation of a new system with a decrease or disappearance of the dominant frequency in the delta range, the appearance of a dominant frequency in the theta range and a subdominant frequency in the alpha range indicates the restoration of brain function. The applied course of neurometabolic therapy leads to such a change in the EEG wavelet graphs after 3-4 weeks in 86.6% of patients. And in the control group, similar changes occur during this period only in 53.3% of patients. Conclusions: To assess the effectiveness of treatment of acute and chronic cerebral ischemia, it is advisable to use a complex of amplitude-time representation of an EEG signal using continuous wavelet transform. The effectiveness of neuromethobolic therapy aimed at eliminating mitochondrial dysfunction can be assessed using the method of quantitative EEG with wavelet transformation, to study the formation and destruction of stable pathological brain systems in patients with cerebral ischemia.