Bio-feedback iontophoresis patch for controllable transdermal drug delivery

2013 IEEE Biomedical Circuits and Systems Conference (BioCAS) Pub Date : 2013-12-12 DOI:10.1109/BIOCAS.2013.6679706

Kiseok Song, U. Ha, Jaehyuk Lee, H. Yoo

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引用次数: 2

Abstract

The bio-feedback iontophoresis patch is proposed for controllable transdermal drug delivery. The proposed iontophoresis patch is implemented with the bio-feedback iontophoresis integrated circuit (IC) on the planar-fashionable circuit board (P-FCB) technology. For controllable iontophoresis treatment, the bio-feedback iontophoresis IC provides programmable stimulation current (16-512μA amplitude, DC-500Hz frequency, and 3-100% duty cycle) and monitors the dual-mode (load and tissue) impedance and the skin temperature during iontophoresis treatment with the reconfigurable tetra-polar electrode configuration. The load impedance is used to determine the stimulation current level, which means the instantaneous delivered dosage, for optimized iontophoresis treatment. The measured tissue impedance is used as an indicator of the accumulated delivered dosage. The skin temperature sensor prevents the unexpected side effects, such as skin burn or tissue destruction. As a result, the proposed iontophoresis patch monitors drug delivery status and patient's status. The proposed iontophoresis system is fully implemented and verified on both in-vitro and in-vivo tests.

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可控透皮给药的生物反馈离子导入贴片

提出了一种生物反馈离子导入贴片，用于可控的透皮给药。所提出的离子导入贴片采用平面时尚电路板(P-FCB)技术上的生物反馈离子导入集成电路(IC)实现。为了实现可控的离子透入处理，生物反馈离子透入IC提供可编程的刺激电流(16-512μA振幅，DC-500Hz频率，3-100%占空比)，并通过可重构的四极电极配置监测离子透入处理过程中的双模(负载和组织)阻抗和皮肤温度。负载阻抗用于确定刺激电流水平，即瞬时输送剂量，以优化离子导入处理。测量的组织阻抗用作累积递送剂量的指示器。皮肤温度传感器防止意外的副作用，如皮肤烧伤或组织破坏。因此，所提出的离子透入贴片监测药物递送状态和患者状态。所提出的离子透入系统在体外和体内测试中都得到了充分的实施和验证。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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2013 IEEE Biomedical Circuits and Systems Conference (BioCAS)

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