Pengaruh Konsentrasi Carbopol 940 Sebagai Gelling Agent Terhadap Stabilitas Fisik Sediaan Gel Lidah Buaya (Aloe Vera)

N. Thomas, Robert Tungadi, Faramita Hiola, Multiani S. Latif
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Abstract

Carbopol 940 is a gelling agent that is very communly used in cosmetic production because of its high compatibility and stability, and it is non-toxic when applied to the skin and it spreads on the skin more easilym gels are semi solid preparations that contain a gel-forming agent which gives stiffiness to collodial solutions or dispersions used for external use on the skin, gel preparations are widely chosen because they are very easy to apply ( easily smeared, absorbed, and cleaned) and more attractive (transparent) compared to the other topical preparations. the purpose of this study was to determine the effect of carbopol concentration 940 as a gelling agent on the physical stability of aloe vera gel preparations. this study began with optimization of the carbopol 940 gel base then the preparation formulation used 50% aloe vera extract, 0,5% carbopol 940 F1, 1 % F2, 2% F3, 10 % propylene glycol, 10% glycerine, 0,1% dm dm hydantoin and sufficient aquadest, afterward the evaluation of the preparation included organoleptic, observations, homogeneity tests, pH tests, spreadability tests, adhesion tests and viscosity tests. carbopol 940 was depeloped using co-free water. gel preparations were 0,5%, 1%, and 2%. the results showed that the thrid formulation (F3) with a concentration of 2% fulfilled the physical evaluation requirements for organoleptic, spreadability, adhesion, viscosity, pH and homogeneity tests.
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Carbopol 940作为Gelling Agent的浓度对芦荟库存稳定的影响
卡波波尔940是一种胶凝剂,在化妆品生产中广泛使用,因为它具有很高的相容性和稳定性,当它应用于皮肤时是无毒的,它更容易在皮肤上扩散。凝胶是一种半固体制剂,含有凝胶形成剂,使胶体溶液或分散剂具有硬度,用于皮肤外用,凝胶制剂被广泛选择,因为它们非常容易应用(容易涂抹,容易吸收,与其他外用制剂相比,更有吸引力(透明)。本研究的目的是确定卡波醇浓度940作为胶凝剂对芦荟凝胶制剂物理稳定性的影响。本研究首先对卡波醇940凝胶基进行了优化,然后将50%芦荟提取物、0.5%卡波醇940 F1、1% F2、2% F3、10%丙二醇、10%甘油、0.1% dm -缬氨酸和足量水凝胶作为制剂配方,随后对制剂进行了感官、观察、均匀性、pH、涂布性、粘附性和粘度等评价。Carbopol 940是用无co水制备的。凝胶制剂分别为0、5%、1%和2%。结果表明,第3配方(F3)在2%的浓度下满足感官、涂抹性、粘附性、粘度、pH和均匀性等物理评价要求。
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