Corona virous is the cause of infection with Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). This disease was named by the World Health Organization, namely Coronavirus Disease 2019 or also known as COVID-19. In the management of COVID-19 patients using antibiotic therapy. Azithromycin is a broad-spectrum macrolide antibiotic that is the first line in the treatment of COVID- 19, because azithromycin has anti-inflammatory properties. The purpose of this study was to examine the side effects of using azithromycin as a treatment in COVID-19 patients based on a systematic review of various research articles that have been carried out. The method used is Literature review with SPIDER analysis. The results showed that azithromycin caused side effects in COVID-19 patients in the form of sudden cardiac death by triggering torsade de pointes and other ventricular arrhythmias. The conclusion is that azithromycin has been shown to cause the most side effects in COVID-19 patients.
{"title":"Narrative Review : Efek Samping Penggunaan Antibiotik Azitromycin Pada Pasien Covid-19","authors":"Valentina Dian Suryani, Nera Umilia Purwanti, Nurmainah Nurmainah","doi":"10.37311/ijpe.v3i2.20720","DOIUrl":"https://doi.org/10.37311/ijpe.v3i2.20720","url":null,"abstract":"Corona virous is the cause of infection with Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). This disease was named by the World Health Organization, namely Coronavirus Disease 2019 or also known as COVID-19. In the management of COVID-19 patients using antibiotic therapy. Azithromycin is a broad-spectrum macrolide antibiotic that is the first line in the treatment of COVID- 19, because azithromycin has anti-inflammatory properties. The purpose of this study was to examine the side effects of using azithromycin as a treatment in COVID-19 patients based on a systematic review of various research articles that have been carried out. The method used is Literature review with SPIDER analysis. The results showed that azithromycin caused side effects in COVID-19 patients in the form of sudden cardiac death by triggering torsade de pointes and other ventricular arrhythmias. The conclusion is that azithromycin has been shown to cause the most side effects in COVID-19 patients.","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"311 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116686756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-24DOI: 10.37311/ijpe.v3i2.18050
N. Thomas, Robert Tungadi, Faramita Hiola, Multiani S. Latif
Carbopol 940 is a gelling agent that is very communly used in cosmetic production because of its high compatibility and stability, and it is non-toxic when applied to the skin and it spreads on the skin more easilym gels are semi solid preparations that contain a gel-forming agent which gives stiffiness to collodial solutions or dispersions used for external use on the skin, gel preparations are widely chosen because they are very easy to apply ( easily smeared, absorbed, and cleaned) and more attractive (transparent) compared to the other topical preparations. the purpose of this study was to determine the effect of carbopol concentration 940 as a gelling agent on the physical stability of aloe vera gel preparations. this study began with optimization of the carbopol 940 gel base then the preparation formulation used 50% aloe vera extract, 0,5% carbopol 940 F1, 1 % F2, 2% F3, 10 % propylene glycol, 10% glycerine, 0,1% dm dm hydantoin and sufficient aquadest, afterward the evaluation of the preparation included organoleptic, observations, homogeneity tests, pH tests, spreadability tests, adhesion tests and viscosity tests. carbopol 940 was depeloped using co-free water. gel preparations were 0,5%, 1%, and 2%. the results showed that the thrid formulation (F3) with a concentration of 2% fulfilled the physical evaluation requirements for organoleptic, spreadability, adhesion, viscosity, pH and homogeneity tests.
{"title":"Pengaruh Konsentrasi Carbopol 940 Sebagai Gelling Agent Terhadap Stabilitas Fisik Sediaan Gel Lidah Buaya (Aloe Vera)","authors":"N. Thomas, Robert Tungadi, Faramita Hiola, Multiani S. Latif","doi":"10.37311/ijpe.v3i2.18050","DOIUrl":"https://doi.org/10.37311/ijpe.v3i2.18050","url":null,"abstract":"Carbopol 940 is a gelling agent that is very communly used in cosmetic production because of its high compatibility and stability, and it is non-toxic when applied to the skin and it spreads on the skin more easilym gels are semi solid preparations that contain a gel-forming agent which gives stiffiness to collodial solutions or dispersions used for external use on the skin, gel preparations are widely chosen because they are very easy to apply ( easily smeared, absorbed, and cleaned) and more attractive (transparent) compared to the other topical preparations. the purpose of this study was to determine the effect of carbopol concentration 940 as a gelling agent on the physical stability of aloe vera gel preparations. this study began with optimization of the carbopol 940 gel base then the preparation formulation used 50% aloe vera extract, 0,5% carbopol 940 F1, 1 % F2, 2% F3, 10 % propylene glycol, 10% glycerine, 0,1% dm dm hydantoin and sufficient aquadest, afterward the evaluation of the preparation included organoleptic, observations, homogeneity tests, pH tests, spreadability tests, adhesion tests and viscosity tests. carbopol 940 was depeloped using co-free water. gel preparations were 0,5%, 1%, and 2%. the results showed that the thrid formulation (F3) with a concentration of 2% fulfilled the physical evaluation requirements for organoleptic, spreadability, adhesion, viscosity, pH and homogeneity tests.","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114744580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-17DOI: 10.37311/ijpe.v3i2.20196
I. Indra, Hurria Hurria, Suhandra Makkasau
Antibiotics are the drugs most widely used in infections caused by bacteria where oral route antibiotics are the first choice in infection therapy. Various studies have found that around 40-62% of antibiotics are used inappropriately, including for diseases that actually do not require antibiotics. The problem that often occurs is the lack of knowledge of inpatients about the proper use of antibiotics. This research was conducted to determine the level of knowledge of inpatients about the use of antibiotics, using a cross sectional descriptive method. Data was taken secondary through filling out a questionnaire. A total of 92 inpatients at x Hospital in Palopo City were selected as volunteers using the accidental sampling method. Data was processed using the Statistical Product and Servicer Solution (SPSS) application with the chi-square test. The results obtained from 92 respondents, as many as 16.3% of respondents had a low level of knowledge, 56.5% of respondents had a sufficient level of knowledge and 27.2% of respondents had a high level of knowledge. There is a relationship between the last level of education (p value 0.000 0.05), with the level of knowledge in using antibiotics. The conclusion of this study is that the level of knowledge of inpatients at x Hospital in Palopo City is quite adequate, namely 56.5%.
抗生素是最广泛应用于细菌感染的药物，口服抗生素是感染治疗的首选药物。各种研究发现，约有40-62%的抗生素使用不当，包括用于实际上不需要抗生素的疾病。经常出现的问题是住院病人缺乏正确使用抗生素的知识。本研究采用横断面描述性方法，以确定住院患者对抗生素使用的知识水平。通过填写问卷，数据是次要的。采用随机抽样的方法，选取Palopo市x医院92名住院患者作为志愿者。数据处理采用SPSS (Statistical Product and service Solution)软件，采用卡方检验。92名受访者的调查结果显示，16.3%的受访者知识水平较低，56.5%的受访者知识水平较好，27.2%的受访者知识水平较高。最后受教育程度与抗生素使用知识水平之间存在相关关系(p值0.000 0.05)。本研究的结论是，Palopo市x医院住院患者的知识水平相当充足，占56.5%。
{"title":"Tingkat Pengetahuan Pasien Rawat Inap Tentang Penggunaan Antibiotik di Rumah Sakit X Kota Palopo","authors":"I. Indra, Hurria Hurria, Suhandra Makkasau","doi":"10.37311/ijpe.v3i2.20196","DOIUrl":"https://doi.org/10.37311/ijpe.v3i2.20196","url":null,"abstract":"Antibiotics are the drugs most widely used in infections caused by bacteria where oral route antibiotics are the first choice in infection therapy. Various studies have found that around 40-62% of antibiotics are used inappropriately, including for diseases that actually do not require antibiotics. The problem that often occurs is the lack of knowledge of inpatients about the proper use of antibiotics. This research was conducted to determine the level of knowledge of inpatients about the use of antibiotics, using a cross sectional descriptive method. Data was taken secondary through filling out a questionnaire. A total of 92 inpatients at x Hospital in Palopo City were selected as volunteers using the accidental sampling method. Data was processed using the Statistical Product and Servicer Solution (SPSS) application with the chi-square test. The results obtained from 92 respondents, as many as 16.3% of respondents had a low level of knowledge, 56.5% of respondents had a sufficient level of knowledge and 27.2% of respondents had a high level of knowledge. There is a relationship between the last level of education (p value 0.000 0.05), with the level of knowledge in using antibiotics. The conclusion of this study is that the level of knowledge of inpatients at x Hospital in Palopo City is quite adequate, namely 56.5%.","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116174760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-13DOI: 10.37311/ijpe.v3i2.20414
Muhamad Handoyo Sahumena, S. Suryani, Widya Pratiwi
Miana (Coleus atropurpureus L. Benth) is a plant in the ornamental plant group that has benefits for the body. The part of the plant that is efficacious as medicine is on the leaves with a brownish red color. However, extracts from miana leaves are hydrophilic, making it difficult to penetrate biological membranes which are rich in lipids and difficult to use topically. One way to overcome this problem is by making liposome carrier systems. Liposomes are carrier systems consisting of phospholipids and cholesterol with the ability to encapsulate hydrophilic and hydrophobic compounds. Parameters for the success of the liposome formula include vesicle shape, high adsorption efficiency and liposome vesicle size using a particle size analyzer (PSA). The liposome formula was obtained through the thin layer hydration method using phosphatidylcholine and cholesterol. The composition of the optimum liposome formula of miana leaf ethanol extract is 0.2% phosphatidylcholine and 0.4% cholesterol. The optimum formula obtained is a complex spherical structure, efficiency entrapment 92.91%, vesicle size 573.6 nm and polydispersity index is 0,505.
Miana (Coleus atropurpureus L. Benth)是一种对身体有益的观赏植物。植物中有药用功效的部分在叶子上，呈棕红色。然而，棕榈叶提取物是亲水的，这使得它很难穿透富含脂质的生物膜，难以局部使用。克服这个问题的一种方法是制造脂质体载体系统。脂质体是由磷脂和胆固醇组成的载体系统，具有包封亲水性和疏水性化合物的能力。脂质体配方的成功参数包括囊泡形状、高吸附效率和脂质体囊泡大小(使用粒径分析仪(PSA))。以磷脂酰胆碱和胆固醇为原料，采用薄层水合法制备脂质体配方。棉麻叶乙醇提取物的最佳脂质体配方为0.2%磷脂酰胆碱和0.4%胆固醇。得到的最佳配方为复杂的球形结构，包封效率为92.91%，囊泡尺寸为573.6 nm，多分散性指数为0.0505。
{"title":"Preparasi dan Karakterisasi Sistem Pembawa Liposom dari Ekstrak Etanol Daun Miana (Coleus atropurpureus L. Benth)","authors":"Muhamad Handoyo Sahumena, S. Suryani, Widya Pratiwi","doi":"10.37311/ijpe.v3i2.20414","DOIUrl":"https://doi.org/10.37311/ijpe.v3i2.20414","url":null,"abstract":"Miana (Coleus atropurpureus L. Benth) is a plant in the ornamental plant group that has benefits for the body. The part of the plant that is efficacious as medicine is on the leaves with a brownish red color. However, extracts from miana leaves are hydrophilic, making it difficult to penetrate biological membranes which are rich in lipids and difficult to use topically. One way to overcome this problem is by making liposome carrier systems. Liposomes are carrier systems consisting of phospholipids and cholesterol with the ability to encapsulate hydrophilic and hydrophobic compounds. Parameters for the success of the liposome formula include vesicle shape, high adsorption efficiency and liposome vesicle size using a particle size analyzer (PSA). The liposome formula was obtained through the thin layer hydration method using phosphatidylcholine and cholesterol. The composition of the optimum liposome formula of miana leaf ethanol extract is 0.2% phosphatidylcholine and 0.4% cholesterol. The optimum formula obtained is a complex spherical structure, efficiency entrapment 92.91%, vesicle size 573.6 nm and polydispersity index is 0,505.","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129482227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-12DOI: 10.37311/ijpe.v2i3.20405
Muhamad Handoyo Sahumena, S. Suryani
Ibuprofen is one of the Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) class of propionic acid derivatives which has potent anti-inflammatory and antipyretic activity. The solubility of ibuprofen is disadvantageous because it is practically insoluble and has poor dissolution. The aim of this study was to overcome the solubility of ibuprofen through a stable SNEDDS formula. One way to overcome the solubility of ibuprofen is to prepare nanoemulsions using the Self-Emulsifying Drug Delivery System (SNEDDS) technique. SNEDDS is a form of preemulsion drug which spontaneously forms nanoemulsion when it encounters the aqueous phase in the digestive tract. Parameters for the success of the SNEDDS formula include emulsification time, stability, and droplet size using a particle size analyzer (PSA). The SNEDDS formulation was carried out by mixing span 80 and tween 20, PEG 400 and VCO as the oil phase. The characteristics of SNEDDS ibuprofen include homogeneity of SNEDDS, clarity, transmittance, emulsification time, and droplet size. The composition of the optimum formula for SNEDDS ibuprofen is 1 mL of VCO; 1 mL PEG; 7 mL tween 20; 1 mL span 80. The formula shows good homogeneity, is clear with emulsification time of 15 seconds, transmittance is 92.69%, and droplet size is 221.9 nm.
布洛芬是非甾体抗炎药(NSAIDs)类丙酸衍生物之一，具有很强的抗炎和解热活性。布洛芬的溶解度是不利的，因为它几乎不溶，溶解性差。本研究的目的是通过稳定的sndds配方来克服布洛芬的溶解度。克服布洛芬溶解性的一种方法是利用自乳化给药系统(SNEDDS)技术制备纳米乳液。SNEDDS是一种预乳药物，在消化道中与水相接触后会自发形成纳米乳。SNEDDS配方成功的参数包括乳化时间、稳定性和使用粒径分析仪(PSA)的液滴大小。以PEG 400和VCO为油相，在80和20之间混合制备了SNEDDS配方。SNEDDS布洛芬的特性包括SNEDDS的均匀性、透明度、透光率、乳化时间和液滴大小。SNEDDS布洛芬的最佳配方为1ml VCO;1 mL PEG;7 mL 20间;1毫升跨度80。该配方均匀性好，乳化时间为15 s，透明，透过率为92.69%，液滴尺寸为221.9 nm。
{"title":"Formulasi Self Nano-Emulsifying Drug Delivery System (SNEDDS) Ibuprofen dengan VCO dan Kombinasi Surfaktan","authors":"Muhamad Handoyo Sahumena, S. Suryani","doi":"10.37311/ijpe.v2i3.20405","DOIUrl":"https://doi.org/10.37311/ijpe.v2i3.20405","url":null,"abstract":"Ibuprofen is one of the Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) class of propionic acid derivatives which has potent anti-inflammatory and antipyretic activity. The solubility of ibuprofen is disadvantageous because it is practically insoluble and has poor dissolution. The aim of this study was to overcome the solubility of ibuprofen through a stable SNEDDS formula. One way to overcome the solubility of ibuprofen is to prepare nanoemulsions using the Self-Emulsifying Drug Delivery System (SNEDDS) technique. SNEDDS is a form of preemulsion drug which spontaneously forms nanoemulsion when it encounters the aqueous phase in the digestive tract. Parameters for the success of the SNEDDS formula include emulsification time, stability, and droplet size using a particle size analyzer (PSA). The SNEDDS formulation was carried out by mixing span 80 and tween 20, PEG 400 and VCO as the oil phase. The characteristics of SNEDDS ibuprofen include homogeneity of SNEDDS, clarity, transmittance, emulsification time, and droplet size. The composition of the optimum formula for SNEDDS ibuprofen is 1 mL of VCO; 1 mL PEG; 7 mL tween 20; 1 mL span 80. The formula shows good homogeneity, is clear with emulsification time of 15 seconds, transmittance is 92.69%, and droplet size is 221.9 nm.","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123655605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Endophytic fungi are fungi that live in plant tissues for a certain period and can form colonies in the host's tissues without endangering the host itself. In addition to plants, endophytic fungi are also found in marine biota. Endophytic fungi that live in the internal organs or tissues of marine biota, whether in the form of mold or yeast, can transform the nutrients they obtain from their host animals into metabolite compounds which will then be transferred back to the host organs so that they have the same metabolites as their hosts. This study aimed to analyze and test the antioxidant activity of the secondary metabolites of sea urchins in the Tomini Bay area. The method used from the beginning of the research was endophytic microbial fermentation, production of secondary metabolites, and partitioning of endophytic microbial isolates, namely liquid-liquid; the method used to test antioxidant activity was qualitative using TLC plates, DPPH UV-Vis spectrophotometer method, color reagent, and thin layer chromatography. Two isolates of endophytic fungi were obtained, namely (JBB1, JBB2). The isolate that was active as an antioxidant was JBB2 from sea urchins in the Tomini Bay area with an ICso 50-100 ppm, which was in the strong category. Meanwhile, JBB2 isolate was carried out at a wavelength of 517 nm with a value absorbance of 0,707 A. In accordance with the value of the linear equation, it obtained y = 0,092x+36,95 and an R2 value = 0,945 that the ethyl acetate extract in JBB2 had a moderate ICs of 87.43 µg/mL. Meanwhile, the qualitative test of secondary metabolites using thin layer chromatography with n-hexane eluent: ethyl acetate (8:2) ethyl acetate extract contained alkaloid and terpenoid compounds.
{"title":"Analisis Kualitatif Metabolit Sekunder dan Aktivitas Antioksidan Jamur Endofit Cangkang Bulu Babi (Diadema setosum)","authors":"Widy Susanti Abdulkadir, Mahdalena Sy. Pakaya, Fika Nuzul Ramadhani, Wiwit Zuriyati Uno, Arona Salama","doi":"10.37311/ijpe.v3i2.18019","DOIUrl":"https://doi.org/10.37311/ijpe.v3i2.18019","url":null,"abstract":"Endophytic fungi are fungi that live in plant tissues for a certain period and can form colonies in the host's tissues without endangering the host itself. In addition to plants, endophytic fungi are also found in marine biota. Endophytic fungi that live in the internal organs or tissues of marine biota, whether in the form of mold or yeast, can transform the nutrients they obtain from their host animals into metabolite compounds which will then be transferred back to the host organs so that they have the same metabolites as their hosts. This study aimed to analyze and test the antioxidant activity of the secondary metabolites of sea urchins in the Tomini Bay area. The method used from the beginning of the research was endophytic microbial fermentation, production of secondary metabolites, and partitioning of endophytic microbial isolates, namely liquid-liquid; the method used to test antioxidant activity was qualitative using TLC plates, DPPH UV-Vis spectrophotometer method, color reagent, and thin layer chromatography. Two isolates of endophytic fungi were obtained, namely (JBB1, JBB2). The isolate that was active as an antioxidant was JBB2 from sea urchins in the Tomini Bay area with an ICso 50-100 ppm, which was in the strong category. Meanwhile, JBB2 isolate was carried out at a wavelength of 517 nm with a value absorbance of 0,707 A. In accordance with the value of the linear equation, it obtained y = 0,092x+36,95 and an R2 value = 0,945 that the ethyl acetate extract in JBB2 had a moderate ICs of 87.43 µg/mL. Meanwhile, the qualitative test of secondary metabolites using thin layer chromatography with n-hexane eluent: ethyl acetate (8:2) ethyl acetate extract contained alkaloid and terpenoid compounds.","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131290490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-11DOI: 10.37311/ijpe.v3i2.18611
Muhammad Taupik, A. Mu’thi Andy Suryadi, A. Makkulawu, Siti nuraini Bahar
Rice is a staple food because it contains protein needed by the body is a source of energy. Rice that is white and shiny sometimes attracts people’s attention. Therefore, to increase buyers’ interest, many sellers add bleaching additives such as chlorine ( a chemical to kill germs) without reckoning the side effects that will be inflicted. This study examines the chlorine content in circulated rice in Bone Bolango Regency. This study used seven rice samples to be analyzed through color and precipitation tests. This research implements a mixed method in the form of qualitative as well as Iodometric and Argentometry titrations for quantitative. The results reveal that in the seven rice samples studied, there was no chlorine content due to the absence of discoloration and precipitate. It is supported by the Iodometric and Argentometric tests which show the results of chlorine levels are at 0%.
{"title":"Analisis Cemaran Klorin Pada Beras Dengan Metode Volumetri Studi Kasus : Kabupaten Bone Bolango","authors":"Muhammad Taupik, A. Mu’thi Andy Suryadi, A. Makkulawu, Siti nuraini Bahar","doi":"10.37311/ijpe.v3i2.18611","DOIUrl":"https://doi.org/10.37311/ijpe.v3i2.18611","url":null,"abstract":"Rice is a staple food because it contains protein needed by the body is a source of energy. Rice that is white and shiny sometimes attracts people’s attention. Therefore, to increase buyers’ interest, many sellers add bleaching additives such as chlorine ( a chemical to kill germs) without reckoning the side effects that will be inflicted. This study examines the chlorine content in circulated rice in Bone Bolango Regency. This study used seven rice samples to be analyzed through color and precipitation tests. This research implements a mixed method in the form of qualitative as well as Iodometric and Argentometry titrations for quantitative. The results reveal that in the seven rice samples studied, there was no chlorine content due to the absence of discoloration and precipitate. It is supported by the Iodometric and Argentometric tests which show the results of chlorine levels are at 0%.","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"90 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126724976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-31DOI: 10.37311/ijpe.v3i2.20104
Liska Alfaaizin, A. Arsyad, Yulia Yusrini Djabir
High-fat diet has become one of the risk factors of liver dysfunction due to accumulation of fat in the liver cells. This disorder might be triggered by increased reactive oxygen species (ROS) activity with high-fat consumption. This study aimed to compare protective effect of natural antioxidants black cumin oil, argan oil and olive oil on liver function in wistar rats fed with high-fat diet. Male wistar rats (n = 24) were divided into four treatment groups. Group 1 (negative control) was not given any oil treatment (0,5 ml/g bw), group 2 was given black cumin oil (0,4 ml/g bw), group 3 was given argan oil (0,5 ml/g bw) and group 4 was given olive oil (0,5 ml/g bw). All rats were fed a high-fat diet of 10 gr/day for 2 months. The analysis of liver function tests was performed before and after treatment. With high-fat diet, the negative controls had SGOT of 93.05 ± 47.91 UI/I and SGPT of 43.10 ± 14.64 UI/l. Administration of black cumin oil markedly reduced SGOT (62.05 ± 30.67 UI/l) and SGPT levels (28.81 ± 10.60 UI/l) (P0.05). Argan oil can not reduce SGOT levels (97.92 ± 35.07 UI/l) but can reduce SGPT levels (51.67 ± 15.84 UI/l). Olive oil can not reduce SGOT levels (67.38 ± 29.31 UI/l) but can reduce SGPT levels (50.19 ± 9.70 UI/l). It was concluded that administration of black cumin is more effective to reduce SGOT and SGPT levels in rats with high-fat diet compared to argan oil and olive oil treatments.
{"title":"Perbandingan Perlindungan Minyak Jintan Hitam, Minyak Argan dan Minyak Zaitun terhadap Enzim Hati Tikus Akibat Diet Tinggi Lemak","authors":"Liska Alfaaizin, A. Arsyad, Yulia Yusrini Djabir","doi":"10.37311/ijpe.v3i2.20104","DOIUrl":"https://doi.org/10.37311/ijpe.v3i2.20104","url":null,"abstract":"High-fat diet has become one of the risk factors of liver dysfunction due to accumulation of fat in the liver cells. This disorder might be triggered by increased reactive oxygen species (ROS) activity with high-fat consumption. This study aimed to compare protective effect of natural antioxidants black cumin oil, argan oil and olive oil on liver function in wistar rats fed with high-fat diet. Male wistar rats (n = 24) were divided into four treatment groups. Group 1 (negative control) was not given any oil treatment (0,5 ml/g bw), group 2 was given black cumin oil (0,4 ml/g bw), group 3 was given argan oil (0,5 ml/g bw) and group 4 was given olive oil (0,5 ml/g bw). All rats were fed a high-fat diet of 10 gr/day for 2 months. The analysis of liver function tests was performed before and after treatment. With high-fat diet, the negative controls had SGOT of 93.05 ± 47.91 UI/I and SGPT of 43.10 ± 14.64 UI/l. Administration of black cumin oil markedly reduced SGOT (62.05 ± 30.67 UI/l) and SGPT levels (28.81 ± 10.60 UI/l) (P0.05). Argan oil can not reduce SGOT levels (97.92 ± 35.07 UI/l) but can reduce SGPT levels (51.67 ± 15.84 UI/l). Olive oil can not reduce SGOT levels (67.38 ± 29.31 UI/l) but can reduce SGPT levels (50.19 ± 9.70 UI/l). It was concluded that administration of black cumin is more effective to reduce SGOT and SGPT levels in rats with high-fat diet compared to argan oil and olive oil treatments.","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121605623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-24DOI: 10.37311/ijpe.v3i2.19872
Bimby Irenesia, Puan Sadila Islami, Riski Dwi Utami
Cuts are wounds caused by sharp objects such as knives, swords, razors and glass. According to data from the Arifin Achmad Regional General Hospital, Riau Province, it was noted that the most common type of wound in sharp violence was a cut (66.7%). When a wound occurs, the wound healing process occurs, namely: inflammation, proliferation, and remodeling. During the proliferative phase, fibroblasts influence the reepithelialization process that closes the wound. Handling cuts using acacia honey because acacia honey in wound healing has anti-inflammatory, antibacterial and antioxidant activities. Knowing the effectiveness of acacia honey gel on the number of fibroblasts in white rat (Rattus novergicus) incision wounds. This type of research is an experimental study design with a randomized posttest only control group design that uses acacia honey on cuts in white rats (Rattus novergicus). There was no significant difference between each treatment group: 20% acacia honey gel, 60% acacia honey gel, 80% acacia honey gel, positive control (povidone iodine) and negative control (gel without honey). Giving acacia honey gel could not increase the number of fibroblasts in white rat (Rattus novergicus) incision wounds.
{"title":"Efektivitas Gel Madu Hutan Akasia terhadap Jumlah Fibroblas pada Luka Sayat Tikus Putih (Rattus novergicus)","authors":"Bimby Irenesia, Puan Sadila Islami, Riski Dwi Utami","doi":"10.37311/ijpe.v3i2.19872","DOIUrl":"https://doi.org/10.37311/ijpe.v3i2.19872","url":null,"abstract":"Cuts are wounds caused by sharp objects such as knives, swords, razors and glass. According to data from the Arifin Achmad Regional General Hospital, Riau Province, it was noted that the most common type of wound in sharp violence was a cut (66.7%). When a wound occurs, the wound healing process occurs, namely: inflammation, proliferation, and remodeling. During the proliferative phase, fibroblasts influence the reepithelialization process that closes the wound. Handling cuts using acacia honey because acacia honey in wound healing has anti-inflammatory, antibacterial and antioxidant activities. Knowing the effectiveness of acacia honey gel on the number of fibroblasts in white rat (Rattus novergicus) incision wounds. This type of research is an experimental study design with a randomized posttest only control group design that uses acacia honey on cuts in white rats (Rattus novergicus). There was no significant difference between each treatment group: 20% acacia honey gel, 60% acacia honey gel, 80% acacia honey gel, positive control (povidone iodine) and negative control (gel without honey). Giving acacia honey gel could not increase the number of fibroblasts in white rat (Rattus novergicus) incision wounds.","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129907175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-24DOI: 10.37311/ijpe.v3i2.19905
M. Margaretha, Pratiwi Apridamayanti, Hadi Kurniawan
Indonesia is one of the countries known as the world's banana producer. Banana is one of the local fruits that are widely spread in Pontianak, West Kalimantan. Ambon banana and raja banana are classified as bananas that can be consumed directly, so banana peels are often discarded and considered as waste. Whereas banana peels are rich in nutrients such as macro and micro minerals. The purpose of this study was to determine the mineral levels of calcium in the peels of ambon banana and raja banana. Sample preparation using dry digestion method with 0.5 M HNO3 solvent. Method verification was carried out with parameters of linearity, LOD, LOQ, precision and accuracy. The assay was carried out with atomic absorption spectrophotometry at a wavelength of 422.67 nm. The results showed that the mineral levels of calcium in the wet peels of ambon banana are 104.29 mg/kg and raja banana are 314.79 mg/kg. Based on the research conducted, it can be concluded that the levels of calcium mineral in raja banana peels are higher than ambon banana peels
印度尼西亚是世界上著名的香蕉生产国之一。香蕉是一种当地水果，在西加里曼丹的蓬甸广泛分布。安汶香蕉和拉贾香蕉被归类为可以直接食用的香蕉，所以香蕉皮经常被丢弃，被认为是废物。而香蕉皮富含宏量和微量矿物质等营养物质。本研究的目的是测定安汶香蕉和拉贾香蕉果皮中钙的矿物质含量。用0.5 M HNO3溶剂干消解法制备样品。采用线性度、定量限、定量限、精密度、准确度等参数对方法进行验证。采用原子吸收分光光度法测定，波长为422.67 nm。结果表明，安博香蕉湿皮钙矿物质含量为104.29 mg/kg，拉贾香蕉湿皮钙矿物质含量为314.79 mg/kg。通过研究，可以得出结论，拉贾香蕉皮中的钙矿物质含量高于安汶香蕉皮
{"title":"Analisis Kadar Kalsium pada Kulit Pisang Ambon dan Pisang Raja dengan Metode Spektrofotometri Serapan Atom","authors":"M. Margaretha, Pratiwi Apridamayanti, Hadi Kurniawan","doi":"10.37311/ijpe.v3i2.19905","DOIUrl":"https://doi.org/10.37311/ijpe.v3i2.19905","url":null,"abstract":"Indonesia is one of the countries known as the world's banana producer. Banana is one of the local fruits that are widely spread in Pontianak, West Kalimantan. Ambon banana and raja banana are classified as bananas that can be consumed directly, so banana peels are often discarded and considered as waste. Whereas banana peels are rich in nutrients such as macro and micro minerals. The purpose of this study was to determine the mineral levels of calcium in the peels of ambon banana and raja banana. Sample preparation using dry digestion method with 0.5 M HNO3 solvent. Method verification was carried out with parameters of linearity, LOD, LOQ, precision and accuracy. The assay was carried out with atomic absorption spectrophotometry at a wavelength of 422.67 nm. The results showed that the mineral levels of calcium in the wet peels of ambon banana are 104.29 mg/kg and raja banana are 314.79 mg/kg. Based on the research conducted, it can be concluded that the levels of calcium mineral in raja banana peels are higher than ambon banana peels","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"94 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127072847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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