Role of mean platelet volume in patients with type 2 diabetes mellitus

Abstract

In type 2 diabetes mellitus, increased platelet activity is crucial for the emergence of vascular complications. Mean platelet volume (MPV), an indicator of enhanced platelet activity, may be helpful in identifying the thromboembolic events that lead to these vascular complications. This study aims to assess MPV in Type 2 Diabetes patients and investigate the relationship between MPV and glycaemic and diabetic complications. : A comparative cross-sectional study was carried out on 266 subjects (133 diabetic patients and 133 nondiabetic controls) at B.P Koirala Institute of Health Sciences for a period of one year. MPV was analyzed in both the groups and the potential association of MPV with diabetic complications and glycaemic parameters was evaluated. Statistical analysis was carried out with Student t-test and Pearson Correlation Coefficient.: The results of the study showed that diabetics' MPV was considerably higher than that of non-diabetic controls (10.07 + 1.41 vs. 7.47 + 0.60 fl, P0.001) and that diabetic patients who had complications had significantly higher MPV than those who did not (10.61 + 1.35 vs. 9.37 + 1.15 fl, P0.001). Retinopathy (p=0.004), nephropathy (p=0.001), and Peripheral artery disease (p=0.03) were diabetes complications with significantly increased MPV. With regard to HbA1C, FBS levels, and the duration of diabetes, MPV demonstrated a statistically significant positive connection (p0.001 and positive r-value).: MPV is a cost-effective tool in the early detection of vascular complications in diabetes and hence proves to be a promising indicator in preventing vascular complications.