Pub Date : 2023-06-15DOI: 10.18231/j.ijpo.2023.041
Ankita Deshmukh, S. Nemade, Ramesh Kalshetty, A. Padmanabhan, N. Gadgil
Renal failure can occasionally be caused by oxalate nephropathy. Glyoxylate metabolism abnormalities and particular hepatic enzyme deficits are the causes of primary hyperoxaluria (PH). Increased intestinal absorption, an excessive diet or an increased intake of oxalate precursors can all result in secondary hyperoxaluria. A 13-month old male child with high blood creatinine, low sodium, low calcium levels, high uric acid and low urine specific gravity is the subject of this research. Medullary papillary calcification was detected using sonography (nephrocalcinosis). Calcium oxalate crystals, sparse lymphocytic infiltration and interstitial fibrosis were seen on a renal biopsy. The patient was put on peritoneal dialysis, progresses to anuria and expired due to renal failure.
{"title":"Primary hyperoxaluria: A case report","authors":"Ankita Deshmukh, S. Nemade, Ramesh Kalshetty, A. Padmanabhan, N. Gadgil","doi":"10.18231/j.ijpo.2023.041","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.041","url":null,"abstract":"Renal failure can occasionally be caused by oxalate nephropathy. Glyoxylate metabolism abnormalities and particular hepatic enzyme deficits are the causes of primary hyperoxaluria (PH). Increased intestinal absorption, an excessive diet or an increased intake of oxalate precursors can all result in secondary hyperoxaluria. A 13-month old male child with high blood creatinine, low sodium, low calcium levels, high uric acid and low urine specific gravity is the subject of this research. Medullary papillary calcification was detected using sonography (nephrocalcinosis). Calcium oxalate crystals, sparse lymphocytic infiltration and interstitial fibrosis were seen on a renal biopsy. The patient was put on peritoneal dialysis, progresses to anuria and expired due to renal failure.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115587836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-15DOI: 10.18231/j.ijpo.2023.040
Rushali Saxena, Smita Singh, K. Agarwal
Amphicrine carcinoma is rarely reported in literature. It is characterised by dual positivity of neuroendocrine markers and mucin stain in the same cells depicting divergent differentiation. Recently published WorldHealth Organisation (WHO) classification of neuroendocrine neoplasm of 2022 differentiates it from adenocarcinoma and mixed neuroendocrine-nonneuroendocrine neoplasms (MiNEN) it shows varied histomorphology and on rare occasions neuroendocrine features may not be evident in poorly differentiated carcinoma. Hence, diagnosis based solely on histomorphology can be misleading. This is a case of amphicrine carcinoma in an elderly female which showed poorly differentiated morphology along with signet ring cells. Same cells demonstrated immunopositivity for synaptophysin, chromogranin A and were also positive for mucin stains (PAS, PAS-D and Alcian blue). This case report, thus, emphasises the importance of neuroendocrine markers as a part of routine immunohistochemistry in poorly differentiated gastric carcinomas to aid diagnosis of amphicrine carcinoma.
{"title":"Gastric amphicrine carcinoma: A histopathological diagnostic conundrum","authors":"Rushali Saxena, Smita Singh, K. Agarwal","doi":"10.18231/j.ijpo.2023.040","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.040","url":null,"abstract":"Amphicrine carcinoma is rarely reported in literature. It is characterised by dual positivity of neuroendocrine markers and mucin stain in the same cells depicting divergent differentiation. Recently published WorldHealth Organisation (WHO) classification of neuroendocrine neoplasm of 2022 differentiates it from adenocarcinoma and mixed neuroendocrine-nonneuroendocrine neoplasms (MiNEN) it shows varied histomorphology and on rare occasions neuroendocrine features may not be evident in poorly differentiated carcinoma. Hence, diagnosis based solely on histomorphology can be misleading. This is a case of amphicrine carcinoma in an elderly female which showed poorly differentiated morphology along with signet ring cells. Same cells demonstrated immunopositivity for synaptophysin, chromogranin A and were also positive for mucin stains (PAS, PAS-D and Alcian blue). This case report, thus, emphasises the importance of neuroendocrine markers as a part of routine immunohistochemistry in poorly differentiated gastric carcinomas to aid diagnosis of amphicrine carcinoma.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128513004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-15DOI: 10.18231/j.ijpo.2023.030
P. Kumar M
Chronic Kidney Disease (CKD) is a global health problem and associated with increased morbidity and mortality. Hemodialysis is the most common mode of renal replacement in end stage kidney disease. Variation in hematological and biochemical parameters are the prime factors responsible for morbidity and mortality in CKD patients. Normocytic Normochromic Anemia is a typical morphology seen in CKD patients resulting due to erythropoietin deficiency. Early detection and treatment of these pathologies can improve the quality of life in CKD patients.: 1) To evaluate the clinical manifestations and various pathological changes associated with CKD patients on hemodialysis. 2) To compare and correlate various clinico-pathological parameters in CKD patients on hemodialysis, with special emphasis on diabetic kidney disease.: One year eleven months retrospective study was done at CIMS hospital, which included 50 CKD patients. Complete clinical data were recorded and correlated with various hematological and biochemical parameters. Statistical analysis was performed by chi square test and student’s T test. Out of 50 CKD patients, 86% were male, age group of 41-50 years (62%). The commonest co-morbidity was combined hypertension with diabetes in 44%. Majority (72%) had BP between 140-159mmHg. Most (64%) of the CKD patients were known cases of diabetes. Significantly lower levels of RBC count, hemoglobin, hematocrit and platelet count were found with normocytic normochromic anemia being the commonest morphological type. Significantly increased WBC counts, ESR, serum urea, creatinine and serum phosphate levels were noted in CKD patients. DKD patients showed significant risk compared to NDKD patients. CKD is a progressive, irreversible disease. We found alterations in various haematological and biochemical parameters, which were more severe among DKD patients compared to NDKD patients. Early recognition and management of these changes will have an important impact in improving the quality of life.
{"title":"Clinico-pathological correlation study in chronic kidney disease patients undergoing hemodialysis","authors":"P. Kumar M","doi":"10.18231/j.ijpo.2023.030","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.030","url":null,"abstract":"Chronic Kidney Disease (CKD) is a global health problem and associated with increased morbidity and mortality. Hemodialysis is the most common mode of renal replacement in end stage kidney disease. Variation in hematological and biochemical parameters are the prime factors responsible for morbidity and mortality in CKD patients. Normocytic Normochromic Anemia is a typical morphology seen in CKD patients resulting due to erythropoietin deficiency. Early detection and treatment of these pathologies can improve the quality of life in CKD patients.: 1) To evaluate the clinical manifestations and various pathological changes associated with CKD patients on hemodialysis. 2) To compare and correlate various clinico-pathological parameters in CKD patients on hemodialysis, with special emphasis on diabetic kidney disease.: One year eleven months retrospective study was done at CIMS hospital, which included 50 CKD patients. Complete clinical data were recorded and correlated with various hematological and biochemical parameters. Statistical analysis was performed by chi square test and student’s T test. Out of 50 CKD patients, 86% were male, age group of 41-50 years (62%). The commonest co-morbidity was combined hypertension with diabetes in 44%. Majority (72%) had BP between 140-159mmHg. Most (64%) of the CKD patients were known cases of diabetes. Significantly lower levels of RBC count, hemoglobin, hematocrit and platelet count were found with normocytic normochromic anemia being the commonest morphological type. Significantly increased WBC counts, ESR, serum urea, creatinine and serum phosphate levels were noted in CKD patients. DKD patients showed significant risk compared to NDKD patients. CKD is a progressive, irreversible disease. We found alterations in various haematological and biochemical parameters, which were more severe among DKD patients compared to NDKD patients. Early recognition and management of these changes will have an important impact in improving the quality of life.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129970330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-15DOI: 10.18231/j.ijpo.2023.044
V. Bhanvadia, Ami M Shah, Swati A Ravani
Intraocular medulloepithelioma of cilliary body is a nonhereditary neoplasm of childhood arising from primitive medullary epithelium characterized by cords of multi-layered neuroepithelial cells resembling medullary epithelium of the optic cup. It often present as loss of vision, painful eye & leucocoria. Common signs include secondary glaucoma & dislocated lens. About half of patients undergo surgery before discovery of this tumor. We report a case of cilliary body teratoid benign meduloepithelioma in a 4 year female child, presented as phthisical eye, detected incidentally & relevant literature.
{"title":"Incidental detection of teratoid benign medulloepithelioma of cilliary body of eye- A rare case report & literature review","authors":"V. Bhanvadia, Ami M Shah, Swati A Ravani","doi":"10.18231/j.ijpo.2023.044","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.044","url":null,"abstract":"Intraocular medulloepithelioma of cilliary body is a nonhereditary neoplasm of childhood arising from primitive medullary epithelium characterized by cords of multi-layered neuroepithelial cells resembling medullary epithelium of the optic cup. It often present as loss of vision, painful eye & leucocoria. Common signs include secondary glaucoma & dislocated lens. About half of patients undergo surgery before discovery of this tumor. We report a case of cilliary body teratoid benign meduloepithelioma in a 4 year female child, presented as phthisical eye, detected incidentally & relevant literature.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125315747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-15DOI: 10.18231/j.ijpo.2023.034
Shweta Sabu, Reshma Gafoor, S. Vijay, Aswin Mullath, L. Thomas
Facial artery musculomucosal flaps (FAMM) are frequently utilised to restore medium-sized abnormalities after surgical removal of oral malignancies. This case series provides an overview of how patients are chosen for FAMM flap surgery, the operative anatomy, the surgical procedure, and the benefits of FAMM flap in reconstruction.
{"title":"Versatality of facial artery musculomucosal flap in medium sized defects following ablation of oral cancers - A case series","authors":"Shweta Sabu, Reshma Gafoor, S. Vijay, Aswin Mullath, L. Thomas","doi":"10.18231/j.ijpo.2023.034","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.034","url":null,"abstract":"Facial artery musculomucosal flaps (FAMM) are frequently utilised to restore medium-sized abnormalities after surgical removal of oral malignancies. This case series provides an overview of how patients are chosen for FAMM flap surgery, the operative anatomy, the surgical procedure, and the benefits of FAMM flap in reconstruction.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"279 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121038247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-15DOI: 10.18231/j.ijpo.2023.045
Gourik Gangopadhyay, S. Gautam, Mohd Feroz Alam, Bushra Siddiqui
Diabetes mellitus is a public health problem significantly contributing to morbidity and mortality worldwide. The patients are highly prone to opportunistic infections with major systemic as well as cutaneous fungi. The fungal infections frequent in diabetics include Candidiasis as well as cutaneous Aspergillosis. The most commonly involved species include Aspergillus niger, Aspergillus flavus and Aspergillus fumigatus. Presenting here is a case of 60 years male with history of diabetes mellitus type 2 on oral hypoglycaemic agents, presenting in Medicine Out Patient Department with complaints of progressive painless left cystic medial ankle swelling for last 4 months. Patient was then asked to undergo FNAC which revealed pyogenic inflammation with giant cells and fungal hyphae showing acute angled branching. Furthermore, microbiological confirmation was also done and patient was initiated treatment for the same. This case report underlines the importance of FNAC and Cytological study in the accurate and early diagnosis of Cutaneous Aspergillosis even before the more expensive and time-consuming microbiological diagnostic modalities are applied.
{"title":"Cutaneous aspergillosis in a diabetic patient- A cytological encounter in FNAC","authors":"Gourik Gangopadhyay, S. Gautam, Mohd Feroz Alam, Bushra Siddiqui","doi":"10.18231/j.ijpo.2023.045","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.045","url":null,"abstract":"Diabetes mellitus is a public health problem significantly contributing to morbidity and mortality worldwide. The patients are highly prone to opportunistic infections with major systemic as well as cutaneous fungi. The fungal infections frequent in diabetics include Candidiasis as well as cutaneous Aspergillosis. The most commonly involved species include Aspergillus niger, Aspergillus flavus and Aspergillus fumigatus. Presenting here is a case of 60 years male with history of diabetes mellitus type 2 on oral hypoglycaemic agents, presenting in Medicine Out Patient Department with complaints of progressive painless left cystic medial ankle swelling for last 4 months. Patient was then asked to undergo FNAC which revealed pyogenic inflammation with giant cells and fungal hyphae showing acute angled branching. Furthermore, microbiological confirmation was also done and patient was initiated treatment for the same. This case report underlines the importance of FNAC and Cytological study in the accurate and early diagnosis of Cutaneous Aspergillosis even before the more expensive and time-consuming microbiological diagnostic modalities are applied.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"os-22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127765167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-15DOI: 10.18231/j.ijpo.2023.039
R. Thomas, Purushotham Reddy
Fibrosarcoma is a malignant tumour arising from fibroblasts. Several variants have been described and these prove to be a diagnostic challenge owing to its many mimics, thus often requiring ancillary testing such as immunohistochemistry. The sclerosing epithelioid variant is a poorly recognised entity that poses a therapeutic dilemma. This is a case of Fibrosarcoma-sclerosing epithelioid variant reported in a 62-year-old male who presented with an exophytic lesion on the sole of the foot and was operated for the same. This article stresses on the systematic approach to such a case which will enable the pathologist to arrive at an accurate diagnosis.
{"title":"Sclerosing epithelioid fibrosarcoma- A rare entity with a challenging presentation","authors":"R. Thomas, Purushotham Reddy","doi":"10.18231/j.ijpo.2023.039","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.039","url":null,"abstract":"Fibrosarcoma is a malignant tumour arising from fibroblasts. Several variants have been described and these prove to be a diagnostic challenge owing to its many mimics, thus often requiring ancillary testing such as immunohistochemistry. The sclerosing epithelioid variant is a poorly recognised entity that poses a therapeutic dilemma. This is a case of Fibrosarcoma-sclerosing epithelioid variant reported in a 62-year-old male who presented with an exophytic lesion on the sole of the foot and was operated for the same. This article stresses on the systematic approach to such a case which will enable the pathologist to arrive at an accurate diagnosis.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133161111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-15DOI: 10.18231/j.ijpo.2023.025
Bhanushree C S
{"title":"An enigmatic rare tumor of sino-nasal cavity","authors":"Bhanushree C S","doi":"10.18231/j.ijpo.2023.025","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.025","url":null,"abstract":"","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"214 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115419560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-15DOI: 10.18231/j.ijpo.2023.027
S. Dhule, Qureshi Saba Yasmeen, Piyush Prakash Narkhede, Tooba Fatima Mohammed Shafee, Ishrat Fatema
Ovarian lesions can present in any age of life and has a wide spectrum of presentation. They contribute to most of the pelvic masses encountered in clinical practice in reproductive age group. Histopathological examination is of prime importance in ovarian lesions as it is difficult to diagnose these lesions on basis of clinical history, radiology alone.: To analyse the spectrum of ovarian lesions and to categorize them on basis of histomorphological pattern. A total 132 cases were studied from January 2022 to December 2022. Relevant clinical details and histopathological findings were reviewed and analysed. A total of 132 cases of ovarian lesions were included in this study with age range from 20 years to 72 years. Non neoplastic cases were 71 and neoplastic cases were 61 in present study. Follicular cyst was the commonest non neoplastic lesion (48 cases) followed by haemorrhagic corpus luteal cyst (16 cases). Out of 61 neoplastic lesions, 56 were benign, 3 were borderline and 2 were malignant on histopathological examination. Mucinous cystadenoma was the commonest benign lesion and serous cystadenocarcinoma was the commonest malignant tumour in the present study. Borderline mucinous cyst adenoma was the commonest in borderline cases in our study. Unilateral presentation of ovarian lesions was found in 116 cases and bilateral in 16 cases. In present study majority of cases were of non neoplastic lesions. For accurate management of the ovarian lesions it is important to correlate clinical findings and ultrasonography findings with histopathology diagnosis.
{"title":"A histopathological study of ovarian lesions in a rural medical college","authors":"S. Dhule, Qureshi Saba Yasmeen, Piyush Prakash Narkhede, Tooba Fatima Mohammed Shafee, Ishrat Fatema","doi":"10.18231/j.ijpo.2023.027","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.027","url":null,"abstract":"Ovarian lesions can present in any age of life and has a wide spectrum of presentation. They contribute to most of the pelvic masses encountered in clinical practice in reproductive age group. Histopathological examination is of prime importance in ovarian lesions as it is difficult to diagnose these lesions on basis of clinical history, radiology alone.: To analyse the spectrum of ovarian lesions and to categorize them on basis of histomorphological pattern. A total 132 cases were studied from January 2022 to December 2022. Relevant clinical details and histopathological findings were reviewed and analysed. A total of 132 cases of ovarian lesions were included in this study with age range from 20 years to 72 years. Non neoplastic cases were 71 and neoplastic cases were 61 in present study. Follicular cyst was the commonest non neoplastic lesion (48 cases) followed by haemorrhagic corpus luteal cyst (16 cases). Out of 61 neoplastic lesions, 56 were benign, 3 were borderline and 2 were malignant on histopathological examination. Mucinous cystadenoma was the commonest benign lesion and serous cystadenocarcinoma was the commonest malignant tumour in the present study. Borderline mucinous cyst adenoma was the commonest in borderline cases in our study. Unilateral presentation of ovarian lesions was found in 116 cases and bilateral in 16 cases. In present study majority of cases were of non neoplastic lesions. For accurate management of the ovarian lesions it is important to correlate clinical findings and ultrasonography findings with histopathology diagnosis.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"80 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129752039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-15DOI: 10.18231/j.ijpo.2023.033
A. Prabhu, Kiruthiga K G, R. Pai, L. Mathew, S. Backianathan
Ewing sarcoma is the second most common sarcoma involving the bones in children and adolescents. Published data on the clinical features, morphology, translocation and follow-up of patients with Ewing sarcoma from India, is sparse. Objectives of this study were to analyse the clinico-pathologic features of Ewing sarcoma and compare with translocation status, BCoR immunohistochemistry, treatment and survival. 406 cases of Ewing sarcoma were diagnosed in the Department of Pathology, Christian Medical College, Vellore during the period 2008-2015. 135 patients underwent molecular testing for common translocations by RT-PCR and were included in this study.Mean age of patients at diagnosis was 22 years. Most common location of tumour was appendicular skeleton (31.4%) and 19% had solid organ involvement. Distant metastasis was present in 21.5% patients. Translocation was seen in 63 (46.7%) cases, EWS-FLI1 type I (87%), EWS-FLI1 type II(11%) and one patient had EWS-ERG translocation. Seven out of 30 patients were classified as “Sarcoma with BCOR genetic alteration”. Patients who underwent 6 cycles of chemotherapy had a better mean survival. Mean follow-up was 13.72 months and 3 year event free survival of patients was 93.8%.Percentage of viable tumour <10% was the only significant histologic parameter predicting survival. Age at diagnosis ≤15yrs, female sex, size ≤12cm, extra-osseous site, chemotherapy and translocation positivity predicted an improved survival. This study has analysed the type of mutations/translocations seen in a subset of Indian patients with Ewing sarcoma and correlated the clinical and pathological factors affecting survival.
{"title":"Molecular profile & clinical outcome in 121 cases - experience from a tertiary referral centre in South India","authors":"A. Prabhu, Kiruthiga K G, R. Pai, L. Mathew, S. Backianathan","doi":"10.18231/j.ijpo.2023.033","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.033","url":null,"abstract":"Ewing sarcoma is the second most common sarcoma involving the bones in children and adolescents. Published data on the clinical features, morphology, translocation and follow-up of patients with Ewing sarcoma from India, is sparse. Objectives of this study were to analyse the clinico-pathologic features of Ewing sarcoma and compare with translocation status, BCoR immunohistochemistry, treatment and survival. 406 cases of Ewing sarcoma were diagnosed in the Department of Pathology, Christian Medical College, Vellore during the period 2008-2015. 135 patients underwent molecular testing for common translocations by RT-PCR and were included in this study.Mean age of patients at diagnosis was 22 years. Most common location of tumour was appendicular skeleton (31.4%) and 19% had solid organ involvement. Distant metastasis was present in 21.5% patients. Translocation was seen in 63 (46.7%) cases, EWS-FLI1 type I (87%), EWS-FLI1 type II(11%) and one patient had EWS-ERG translocation. Seven out of 30 patients were classified as “Sarcoma with BCOR genetic alteration”. Patients who underwent 6 cycles of chemotherapy had a better mean survival. Mean follow-up was 13.72 months and 3 year event free survival of patients was 93.8%.Percentage of viable tumour <10% was the only significant histologic parameter predicting survival. Age at diagnosis ≤15yrs, female sex, size ≤12cm, extra-osseous site, chemotherapy and translocation positivity predicted an improved survival. This study has analysed the type of mutations/translocations seen in a subset of Indian patients with Ewing sarcoma and correlated the clinical and pathological factors affecting survival.","PeriodicalId":446035,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134218116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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