{"title":"The Anti-Nociceptive/Anti-Inflammatory Actions of Botulinum Toxin A for the Treatment of Chronic Pain; A Literature Review","authors":"Racha Hajj, Camille Haddad","doi":"10.3844/crdsp.2021.62.70","DOIUrl":null,"url":null,"abstract":"Corresponding author: Racha Hajj Resident, Department of Prosthodontics and Restorative Dentistry, Email: rahajj94@gmail.com Abstract: The aim of this article is to describe the new actions of botulinum toxin A for chronic pain treatment. BT/A inhibits the exocytosis of synaptic vesicles containing the pain mediators neurotransmitters, reduces the post traumatic trigeminal neuralgia pain, inhibits the release of microglia derived TNF-α as well as other pro inflammatory cytokines, viable treatment option in the case of patients who do not respond to conservative treatment methods of chronic pain (medication) BT/A is an emerging treatment for chronic pain; patients with severe chronic facial pain, not responding to conventional treatments, can respond to botulinum type a injections.","PeriodicalId":117844,"journal":{"name":"Current Research in Dentistry","volume":"92 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Research in Dentistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3844/crdsp.2021.62.70","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Corresponding author: Racha Hajj Resident, Department of Prosthodontics and Restorative Dentistry, Email: rahajj94@gmail.com Abstract: The aim of this article is to describe the new actions of botulinum toxin A for chronic pain treatment. BT/A inhibits the exocytosis of synaptic vesicles containing the pain mediators neurotransmitters, reduces the post traumatic trigeminal neuralgia pain, inhibits the release of microglia derived TNF-α as well as other pro inflammatory cytokines, viable treatment option in the case of patients who do not respond to conservative treatment methods of chronic pain (medication) BT/A is an emerging treatment for chronic pain; patients with severe chronic facial pain, not responding to conventional treatments, can respond to botulinum type a injections.
通讯作者:Racha Hajj Resident, Department of Prosthodontics and Restorative Dentistry, Email: rahajj94@gmail.com摘要:本文旨在描述肉毒毒素A在慢性疼痛治疗中的新作用。BT/A抑制含有疼痛介质神经递质的突触囊泡的胞吐，减轻创伤后三叉神经痛的疼痛，抑制小胶质细胞衍生的TNF-α以及其他促炎细胞因子的释放，是慢性疼痛保守治疗方法(药物治疗)无效患者的可行治疗选择。严重的慢性面部疼痛患者，对常规治疗无效，可以对a型肉毒杆菌注射有反应。
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