Carine Mounir Ziadeh, Pascale Habre, Lara Nasr, Helene J Haddad
: The clinical study aimed to evaluate the repeatability of the Intraoral Scanner (IOS) in terms of dental shade selection in comparison to the visual method and to find if the difference between these two methods is clinically acceptable. As well as to assess the impact of tooth position on the repeatability of the IOS in shade selection. Two experienced raters have selected the shades of 38 right maxillary incisors, canines, and molars in 38 patients on two different days under the same clinical conditions using both the visual method and the trio’s intraoral scanner. Vita toothguide 3D-master was used as the shade guide reference for both methods. Delta E (ΔΕ) was calculated to assess the repeatability of each technique and to evaluate the difference in color matching between each observer and the IOS. Data were analyzed using IBM SPSS Statistics for Windows and the level of significance was set at 5%. Results of repeatability assessment between day 1 and day 2 for the visual method and the intraoral scanner were higher in the incisor region but lower in the canine and molar region for the IOS compared to the visual method. However, this difference is not statistically significant in all regions (p>0.05). The color difference between the visual technique and the IOS was significantly lower than the clinical acceptability threshold, except between the second rater and intraoral scanner on day 2 for the molar region. Within the intraoral scanner, the repeatability agreement rate was significantly greater for the central, compared to the canine and molar teeth. The IOS is a reliable instrument for color shade selection compared to the visual method, especially in the anterior region; however, tooth position had an impact on its repeatability.
本临床研究旨在评估口腔内扫描(IOS)在牙色选择方面的可重复性，并与目测法进行比较，以确定这两种方法之间的差异在临床上是否可以接受。以及评估齿位对阴影选择中IOS可重复性的影响。两位经验丰富的评判员在相同的临床条件下，使用视觉方法和三人口腔内扫描仪在不同的两天选择了38名患者的38个右上颌门牙，犬齿和磨牙的阴影。两种方法均以Vita齿导3D-master作为阴影导轨参考。计算Delta E (ΔΕ)以评估每种技术的可重复性，并评估每个观察者与IOS之间的颜色匹配差异。数据采用IBM SPSS Statistics for Windows进行分析，显著性水平设为5%。与目测法相比，目测法和口内扫描仪在第1天和第2天的重复性评估结果在门牙区域较高，而在犬齿和磨牙区域较低。然而，这一差异在所有地区均无统计学意义(p < 0.05)。除了在第2天的磨牙区域，视觉技术与口腔内扫描仪的色差显著低于临床可接受阈值。在口腔内扫描仪中，与犬牙和磨牙相比，中央牙齿的重复性一致性率显着更高。与目测方法相比，IOS是一种可靠的色度选择工具，特别是在前区;然而，牙的位置对其重复性有影响。
{"title":"Dental Color Matching: A Comparison between Visual and Digital Shade Selection Repeatability in the Anterior and Posterior Region: A Clinical Study","authors":"Carine Mounir Ziadeh, Pascale Habre, Lara Nasr, Helene J Haddad","doi":"10.3844/crdsp.2023.8.16","DOIUrl":"https://doi.org/10.3844/crdsp.2023.8.16","url":null,"abstract":": The clinical study aimed to evaluate the repeatability of the Intraoral Scanner (IOS) in terms of dental shade selection in comparison to the visual method and to find if the difference between these two methods is clinically acceptable. As well as to assess the impact of tooth position on the repeatability of the IOS in shade selection. Two experienced raters have selected the shades of 38 right maxillary incisors, canines, and molars in 38 patients on two different days under the same clinical conditions using both the visual method and the trio’s intraoral scanner. Vita toothguide 3D-master was used as the shade guide reference for both methods. Delta E (ΔΕ) was calculated to assess the repeatability of each technique and to evaluate the difference in color matching between each observer and the IOS. Data were analyzed using IBM SPSS Statistics for Windows and the level of significance was set at 5%. Results of repeatability assessment between day 1 and day 2 for the visual method and the intraoral scanner were higher in the incisor region but lower in the canine and molar region for the IOS compared to the visual method. However, this difference is not statistically significant in all regions (p>0.05). The color difference between the visual technique and the IOS was significantly lower than the clinical acceptability threshold, except between the second rater and intraoral scanner on day 2 for the molar region. Within the intraoral scanner, the repeatability agreement rate was significantly greater for the central, compared to the canine and molar teeth. The IOS is a reliable instrument for color shade selection compared to the visual method, especially in the anterior region; however, tooth position had an impact on its repeatability.","PeriodicalId":117844,"journal":{"name":"Current Research in Dentistry","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125700342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Wakwak, Karim Sherif Adly, Abdallah Ahmed Abdelhady, Ahmed Ramadan Elmanakhly
: The preservation of tooth structure is an important factor in the successful restoration of endodontically treated teeth. The loss of structural integrity increases the occurrence of crown fractures and microleakage at the margins of restorations in endodontically treated teeth compared with vital teeth. A total of twenty endocrowns were fabricated in this study and the endocrown was divided into two main groups. Each subgroup was tested after cementation for (marginal gap and fracture strength). To simulate a frequent clinical situation then accept a different type of end crown restoration (IPS E-max cad, IPS E-max press). IPS E-max comprises highly esthetic, high strength materials for both the press and CAD/CAM technology subgroup recorded statistically significant (p<0.05) highest marginal gap mean value (54.85±2.5 μm) followed by O group P subgroup (52.00±4.3 μm) then N group P subgroup (49.47±1.3 μm). CAD/CAM endocrown restoration is better in marginal fit. Microleakage is directly affected by the type of cement of CAD/CAM endocrown. Ceramic endocrown is considered a recent approach in the treatment of endodontically treated teeth with the advantage of the reduction in the amount of loss of tooth structure in comparison to the classical crown with post and core.
{"title":"Microleakage Assessment of CAD/CAM Endo Crown Restorations (an in vitro Study)","authors":"M. Wakwak, Karim Sherif Adly, Abdallah Ahmed Abdelhady, Ahmed Ramadan Elmanakhly","doi":"10.3844/crdsp.2023.1.7","DOIUrl":"https://doi.org/10.3844/crdsp.2023.1.7","url":null,"abstract":": The preservation of tooth structure is an important factor in the successful restoration of endodontically treated teeth. The loss of structural integrity increases the occurrence of crown fractures and microleakage at the margins of restorations in endodontically treated teeth compared with vital teeth. A total of twenty endocrowns were fabricated in this study and the endocrown was divided into two main groups. Each subgroup was tested after cementation for (marginal gap and fracture strength). To simulate a frequent clinical situation then accept a different type of end crown restoration (IPS E-max cad, IPS E-max press). IPS E-max comprises highly esthetic, high strength materials for both the press and CAD/CAM technology subgroup recorded statistically significant (p<0.05) highest marginal gap mean value (54.85±2.5 μm) followed by O group P subgroup (52.00±4.3 μm) then N group P subgroup (49.47±1.3 μm). CAD/CAM endocrown restoration is better in marginal fit. Microleakage is directly affected by the type of cement of CAD/CAM endocrown. Ceramic endocrown is considered a recent approach in the treatment of endodontically treated teeth with the advantage of the reduction in the amount of loss of tooth structure in comparison to the classical crown with post and core.","PeriodicalId":117844,"journal":{"name":"Current Research in Dentistry","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133000891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.3844/crdsp.2022.11.22
B. Petersen, Carl Yu, S. Hutchings, Connor Lemmon, K. Howard, K. Kingsley
: MicroRNAs are abundant small non-coding RNA with a variety of known functions, including transcriptional activation and inhibition. Recent evidence has suggested that microRNA expression may influence the responsiveness of some cancers to chemotherapy, including liver and lung cancers. Some evidence has now suggested that specific microRNAs, such as miR-21, miR-155, and miR-375, may influence oral cancer responsiveness to chemotherapy – although much remains to be discovered. Based on the lack of evidence in this area, the primary objective of this study was to evaluate microRNA expression and responsiveness among oral cancers. Five commercially available oral cancer cell lines (SCC4, SCC9, SCC15, SCC25, CAL27) were obtained from ATCC and cultured and chemotherapy resistance to Cisplatin, Fluorouracil or 5-FU and Paclitaxel or Taxol was assessed. Exosomes were then isolated, confirmed, and processed using Particle Metrix Nano Tracking Analysis (NTA) Subsequently, RNA was isolated from both the exosomes and cellular fractions and qPCR screening was performed to determine the expression of microRNA from cellular and exosomal isolates. Growth assays revealed that SCC15 assays were the least resistant, while CAL27 and SCC4 cells exhibited moderate resistance, and SCC9 and SCC25 cells exhibited strong and differential resistance to these chemotherapeutic agents. The screening revealed all cancers expressed miR-21 and miR-133 with differential expressions of miR-27, miR-135, miR-155, and miR-375 observed. However, the most resistant cell lines, SCC9 and SCC25, were the only cells to express miR-375 and were also the only cells that did not express miR-27, suggesting an association between chemotherapeutic resistance and expression of these specific microRNAs. In addition, miR-21 and miR-133 were identified in exosomes from all oral cancers with differential results observed with miR-133 and miR-135-although miR-27 and miR-375 were not found among any exosomes. Although much remains to be elucidated about the functional roles of these differentially expressed microRNAs, the findings of this study suggest that specific microRNAs including miR-27 and miR-375 may, in fact, function in distinct, different, and opposite pathways among these cell lines. Future research endeavors will need to evaluate the potential role of these microRNAs not only to validate their predictive capabilities as biomarkers but also to ascertain which functional pathways may be involved in the development and progression of oral cancers. corresponds 3.0 10 7 particles per mL for each sample. This analysis provides both the peak and mean diameter of EVs, including exosomes and nanospheres.
{"title":"Differential Expression of Cellular and Exosomal MicroRNA Isolated from Oral Cancer Cells and their Resistance to Chemotherapy","authors":"B. Petersen, Carl Yu, S. Hutchings, Connor Lemmon, K. Howard, K. Kingsley","doi":"10.3844/crdsp.2022.11.22","DOIUrl":"https://doi.org/10.3844/crdsp.2022.11.22","url":null,"abstract":": MicroRNAs are abundant small non-coding RNA with a variety of known functions, including transcriptional activation and inhibition. Recent evidence has suggested that microRNA expression may influence the responsiveness of some cancers to chemotherapy, including liver and lung cancers. Some evidence has now suggested that specific microRNAs, such as miR-21, miR-155, and miR-375, may influence oral cancer responsiveness to chemotherapy – although much remains to be discovered. Based on the lack of evidence in this area, the primary objective of this study was to evaluate microRNA expression and responsiveness among oral cancers. Five commercially available oral cancer cell lines (SCC4, SCC9, SCC15, SCC25, CAL27) were obtained from ATCC and cultured and chemotherapy resistance to Cisplatin, Fluorouracil or 5-FU and Paclitaxel or Taxol was assessed. Exosomes were then isolated, confirmed, and processed using Particle Metrix Nano Tracking Analysis (NTA) Subsequently, RNA was isolated from both the exosomes and cellular fractions and qPCR screening was performed to determine the expression of microRNA from cellular and exosomal isolates. Growth assays revealed that SCC15 assays were the least resistant, while CAL27 and SCC4 cells exhibited moderate resistance, and SCC9 and SCC25 cells exhibited strong and differential resistance to these chemotherapeutic agents. The screening revealed all cancers expressed miR-21 and miR-133 with differential expressions of miR-27, miR-135, miR-155, and miR-375 observed. However, the most resistant cell lines, SCC9 and SCC25, were the only cells to express miR-375 and were also the only cells that did not express miR-27, suggesting an association between chemotherapeutic resistance and expression of these specific microRNAs. In addition, miR-21 and miR-133 were identified in exosomes from all oral cancers with differential results observed with miR-133 and miR-135-although miR-27 and miR-375 were not found among any exosomes. Although much remains to be elucidated about the functional roles of these differentially expressed microRNAs, the findings of this study suggest that specific microRNAs including miR-27 and miR-375 may, in fact, function in distinct, different, and opposite pathways among these cell lines. Future research endeavors will need to evaluate the potential role of these microRNAs not only to validate their predictive capabilities as biomarkers but also to ascertain which functional pathways may be involved in the development and progression of oral cancers. corresponds 3.0 10 7 particles per mL for each sample. This analysis provides both the peak and mean diameter of EVs, including exosomes and nanospheres.","PeriodicalId":117844,"journal":{"name":"Current Research in Dentistry","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133839161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. C. O. Magalhães, Cimar Eustáquio Marques da Silva, Cornelis Robert Springer, R. Carteri, A. L. Lopes, B. C. Teixeira, Bárbara Capitanio de Souza
America Football Club, Medical Department, Belo Horizonte, Brazil Methodist University Center Porto Alegre Institute, Nutrition College, Porto Alegre, Brazil Federal University of Rio Grande do Sul, Physical Education School, Porto Alegre, Brazil State University of Minas Gerais, Physical Education College, Ibirité, Brazil Federal University of Rio Grande do Sul, Dentistry College, Porto Alegre, Brazil
{"title":"Survey on Oral Health and History of Muscle Injury in Professional Athletes of Brazilian Women's Soccer: A Cross-Sectional Self-Reported Study","authors":"F. C. O. Magalhães, Cimar Eustáquio Marques da Silva, Cornelis Robert Springer, R. Carteri, A. L. Lopes, B. C. Teixeira, Bárbara Capitanio de Souza","doi":"10.3844/crdsp.2022.1.10","DOIUrl":"https://doi.org/10.3844/crdsp.2022.1.10","url":null,"abstract":"America Football Club, Medical Department, Belo Horizonte, Brazil Methodist University Center Porto Alegre Institute, Nutrition College, Porto Alegre, Brazil Federal University of Rio Grande do Sul, Physical Education School, Porto Alegre, Brazil State University of Minas Gerais, Physical Education College, Ibirité, Brazil Federal University of Rio Grande do Sul, Dentistry College, Porto Alegre, Brazil","PeriodicalId":117844,"journal":{"name":"Current Research in Dentistry","volume":"121 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116394919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.20944/PREPRINTS202101.0139.V1
G. Aoun
The thyroid gland secretes essential hormones for the growth regulation and the metabolic activity of the body. Thyroid dysfunction includes many conditions that can indirectly affect dental treatments. Therefore, the practitioner must be aware of these pathologies and their signs and symptoms in order to elaborate specific dental treatment plans, thus avoiding any per- and/or postoperative complications. Moreover, the dentist can help in the screening of undiagnosed thyroid dysfunction among patients.
{"title":"Thyroid Dysfunction: Risk and Management in Dentistry","authors":"G. Aoun","doi":"10.20944/PREPRINTS202101.0139.V1","DOIUrl":"https://doi.org/10.20944/PREPRINTS202101.0139.V1","url":null,"abstract":"The thyroid gland secretes essential hormones for the growth regulation and the metabolic activity of the body. Thyroid dysfunction includes many conditions that can indirectly affect dental treatments. Therefore, the practitioner must be aware of these pathologies and their signs and symptoms in order to elaborate specific dental treatment plans, thus avoiding any per- and/or postoperative complications. Moreover, the dentist can help in the screening of undiagnosed thyroid dysfunction among patients.","PeriodicalId":117844,"journal":{"name":"Current Research in Dentistry","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125830133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.20944/PREPRINTS202101.0400.V1
Georges Abi Khalil, G. Aoun, Banine Khalifeh, T. Zeinoun
Ameloblastoma is an aggressive slow growing benign epithelial odontogenic tumor usually associated with an unerupted third molar. In this report, we present the case of a 71-year-old male with a large swelling on the left mandibular region causing a remarkable facial asymmetry. After clinical, radiological, and histopathological examinations the diagnosis of conventional ameloblastoma was made. To avoid probable recurrence our treatment choice was a segmental mandibular resection with the placement of a reconstructive titanium plate to maintain the space for subsequent bone graft.
{"title":"Segmental Mandibular Resection for Conventional Ameloblastoma","authors":"Georges Abi Khalil, G. Aoun, Banine Khalifeh, T. Zeinoun","doi":"10.20944/PREPRINTS202101.0400.V1","DOIUrl":"https://doi.org/10.20944/PREPRINTS202101.0400.V1","url":null,"abstract":"Ameloblastoma is an aggressive slow growing benign epithelial odontogenic tumor usually associated with an unerupted third molar. In this report, we present the case of a 71-year-old male with a large swelling on the left mandibular region causing a remarkable facial asymmetry. After clinical, radiological, and histopathological examinations the diagnosis of conventional ameloblastoma was made. To avoid probable recurrence our treatment choice was a segmental mandibular resection with the placement of a reconstructive titanium plate to maintain the space for subsequent bone graft.","PeriodicalId":117844,"journal":{"name":"Current Research in Dentistry","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134011945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.3844/crdsp.2021.62.70
Racha Hajj, Camille Haddad
Corresponding author: Racha Hajj Resident, Department of Prosthodontics and Restorative Dentistry, Email: rahajj94@gmail.com Abstract: The aim of this article is to describe the new actions of botulinum toxin A for chronic pain treatment. BT/A inhibits the exocytosis of synaptic vesicles containing the pain mediators neurotransmitters, reduces the post traumatic trigeminal neuralgia pain, inhibits the release of microglia derived TNF-α as well as other pro inflammatory cytokines, viable treatment option in the case of patients who do not respond to conservative treatment methods of chronic pain (medication) BT/A is an emerging treatment for chronic pain; patients with severe chronic facial pain, not responding to conventional treatments, can respond to botulinum type a injections.
通讯作者:Racha Hajj Resident, Department of Prosthodontics and Restorative Dentistry, Email: rahajj94@gmail.com摘要:本文旨在描述肉毒毒素A在慢性疼痛治疗中的新作用。BT/A抑制含有疼痛介质神经递质的突触囊泡的胞吐，减轻创伤后三叉神经痛的疼痛，抑制小胶质细胞衍生的TNF-α以及其他促炎细胞因子的释放，是慢性疼痛保守治疗方法(药物治疗)无效患者的可行治疗选择。严重的慢性面部疼痛患者，对常规治疗无效，可以对a型肉毒杆菌注射有反应。
{"title":"The Anti-Nociceptive/Anti-Inflammatory Actions of Botulinum Toxin A for the Treatment of Chronic Pain; A Literature Review","authors":"Racha Hajj, Camille Haddad","doi":"10.3844/crdsp.2021.62.70","DOIUrl":"https://doi.org/10.3844/crdsp.2021.62.70","url":null,"abstract":"Corresponding author: Racha Hajj Resident, Department of Prosthodontics and Restorative Dentistry, Email: rahajj94@gmail.com Abstract: The aim of this article is to describe the new actions of botulinum toxin A for chronic pain treatment. BT/A inhibits the exocytosis of synaptic vesicles containing the pain mediators neurotransmitters, reduces the post traumatic trigeminal neuralgia pain, inhibits the release of microglia derived TNF-α as well as other pro inflammatory cytokines, viable treatment option in the case of patients who do not respond to conservative treatment methods of chronic pain (medication) BT/A is an emerging treatment for chronic pain; patients with severe chronic facial pain, not responding to conventional treatments, can respond to botulinum type a injections.","PeriodicalId":117844,"journal":{"name":"Current Research in Dentistry","volume":"92 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115106784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.3844/crdsp.2021.71.76
Alexander Saber, A. Kassir, N. Naaman, N. Mokbel, Layal Bou Semaan, M. Dagher
Layal A. Bou Semaan Department of Periodontology, Faculty of Dental Medicine, Saint Joseph University of Beirut, Lebanon Email: layal.bs@live.com Abstract: The aim of this randomized control trial was to compare the analgesic efficacy of two commonly prescribed medications, mefenamic acid (PonstanTM Forte) and lysine clonixinate (Dorixina®) in patients undergoing dental implant surgery. A total of 130 patients receiving dental implants were randomized into two groups: 75 Treated with Mefenamic Acid (MA) and 75 with Lysine Clonixinate (LC). The primary outcome was the change in pain scores according to a Visual Analog Scale (VAS) recorded by the patients on a questionnaire over 7 days post-operatively. Secondary outcome was analgesic consumption taken as a rescue medication. 102 patients (78.5%) completed questionnaires and were available for analysis. No significant difference was found for both outcome measures during the first 4 days post-operative. However, the mean VAS score was significantly lower in LC group at days 5, 6 and 7 compared to MA group. The results of this study suggests that there is no difference in the analgesic efficacy between MA and LC when prescribed as pain medications following dental implant surgery. The abovementioned findings will help clinicians to have a better understanding of the analgesic efficacy of two different medications in implant surgery. When anti-inflammatory drugs are contraindicated in patients undergoing implant treatment, LC can be safely prescribed with the same analgesic efficacy of an AINS.
{"title":"Comparison of the Analgesic Efficacy of Two Medications in Patients Receiving Dental Implants a Randomized Controlled Trial","authors":"Alexander Saber, A. Kassir, N. Naaman, N. Mokbel, Layal Bou Semaan, M. Dagher","doi":"10.3844/crdsp.2021.71.76","DOIUrl":"https://doi.org/10.3844/crdsp.2021.71.76","url":null,"abstract":"Layal A. Bou Semaan Department of Periodontology, Faculty of Dental Medicine, Saint Joseph University of Beirut, Lebanon Email: layal.bs@live.com Abstract: The aim of this randomized control trial was to compare the analgesic efficacy of two commonly prescribed medications, mefenamic acid (PonstanTM Forte) and lysine clonixinate (Dorixina®) in patients undergoing dental implant surgery. A total of 130 patients receiving dental implants were randomized into two groups: 75 Treated with Mefenamic Acid (MA) and 75 with Lysine Clonixinate (LC). The primary outcome was the change in pain scores according to a Visual Analog Scale (VAS) recorded by the patients on a questionnaire over 7 days post-operatively. Secondary outcome was analgesic consumption taken as a rescue medication. 102 patients (78.5%) completed questionnaires and were available for analysis. No significant difference was found for both outcome measures during the first 4 days post-operative. However, the mean VAS score was significantly lower in LC group at days 5, 6 and 7 compared to MA group. The results of this study suggests that there is no difference in the analgesic efficacy between MA and LC when prescribed as pain medications following dental implant surgery. The abovementioned findings will help clinicians to have a better understanding of the analgesic efficacy of two different medications in implant surgery. When anti-inflammatory drugs are contraindicated in patients undergoing implant treatment, LC can be safely prescribed with the same analgesic efficacy of an AINS.","PeriodicalId":117844,"journal":{"name":"Current Research in Dentistry","volume":"341 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122323122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Destructive peri-implant bone loss is distressing for both the patient and the treating dentist(s). In severe cases peri-implant bone loss may cause jawbone mutilation, making re-treatment highly complex or impossible and violating the treatment philosophy of “first, do no harm”. There are a multitude of causes of bone loss around a dental implant. These include, but are not limited to, post-operative bone remodeling; the skills or otherwise of the surgeon, the restorative dentist and technicians; patient factors (smoking, bruxing, health and disease of the oral hard and soft tissues, systemic disease); a dis-balanced immunobiological response to the placement of a foreign body; the physical, chemical and topographical properties of the implant; and the response of the commensal bone biofilm populations to the placement of the implant. This paper looks at one possible cause of destructive, peri-implant bone loss and the response of the commensal bone biofilms to the placement of the implant, including the influence that surface topography may have on the behavior of the biofilm populations. A new classification of bone quality and health, based on radiographical anatomy and the associated microbial ecology, is proposed. An aetiology of biofilm-mediated, surface-induced, destructive peri-implant bone loss is described.
{"title":"On Destructive Peri-implant Bone Loss","authors":"A. Viljoen","doi":"10.3844/crdsp.2019.1.17","DOIUrl":"https://doi.org/10.3844/crdsp.2019.1.17","url":null,"abstract":"Destructive peri-implant bone loss is distressing for both the patient and the treating dentist(s). In severe cases peri-implant bone loss may cause jawbone mutilation, making re-treatment highly complex or impossible and violating the treatment philosophy of “first, do no harm”. There are a multitude of causes of bone loss around a dental implant. These include, but are not limited to, post-operative bone remodeling; the skills or otherwise of the surgeon, the restorative dentist and technicians; patient factors (smoking, bruxing, health and disease of the oral hard and soft tissues, systemic disease); a dis-balanced immunobiological response to the placement of a foreign body; the physical, chemical and topographical properties of the implant; and the response of the commensal bone biofilm populations to the placement of the implant. This paper looks at one possible cause of destructive, peri-implant bone loss and the response of the commensal bone biofilms to the placement of the implant, including the influence that surface topography may have on the behavior of the biofilm populations. A new classification of bone quality and health, based on radiographical anatomy and the associated microbial ecology, is proposed. An aetiology of biofilm-mediated, surface-induced, destructive peri-implant bone loss is described.","PeriodicalId":117844,"journal":{"name":"Current Research in Dentistry","volume":"146 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116466744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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