Integrated plasmonic refractive index sensor based on grating/metal film resonant structure

SPIE OPTO Pub Date : 2016-03-15 DOI:10.1117/12.2218558
Mingze Sun, T. Sun, Youhai Liu, Li Zhu, Fang Liu, Yidong Huang, C. Chang-Hasnain
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引用次数: 10

Abstract

Optical biosensors with the high sensitivity is an important tool for environment monitoring, disease diagnosis and drug development. Integrating the biosensor could reduce the size and cost and is desirable for home and outdoor use. However, the integrated structure always results in the worsening of sensitivity and narrowing of sensing range, especially for small molecule sensing. In this work, we propose an integrated plasmonic biosensor based on the resonant structure composed of dielectric grating and metal film. With vertically incident light from the grating side, the surface plasmon polariton (SPP) mode could be excited at certain wavelength and the reflected light would vanish. Simulation results indicate that, when varying refractive index (ndet) of detection layer, the energy of reflected light changes dramatically. Assuming the resolution of the power meter is 0.01dB, the sensing resolution could be 4.37×10-6 RIU, which is very close to the bulk lens based SPP biosensor by monitoring the light intensity variation. Since antibody and antigen always have the size of tens of nanometers, it is necessary to check the sensing ability of the sensor in tens of nanometers. Fixing ndet and varying the thickness of detection layer, calculation result demonstrates that the reflected light energy is sensitive to the thickness change with one hundred nanometers. This attributes to the surface mode property of SPP mode.
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基于光栅/金属薄膜谐振结构的集成等离子体折射率传感器
光学生物传感器具有很高的灵敏度,是环境监测、疾病诊断和药物开发的重要工具。集成生物传感器可以减小尺寸和成本,适合家庭和户外使用。然而,集成的结构往往导致灵敏度的下降和传感范围的缩小,特别是对于小分子传感。在这项工作中,我们提出了一种基于由介电光栅和金属薄膜组成的谐振结构的集成等离子体生物传感器。当光从光栅侧垂直入射时,表面等离子激元(SPP)模式在一定波长处被激发,反射光消失。仿真结果表明,当探测层的折射率(ndet)发生变化时,反射光的能量发生显著变化。假设功率计的分辨率为0.01dB,通过监测光强变化,传感分辨率可以达到4.37×10-6 RIU,与基于体透镜的SPP生物传感器非常接近。由于抗体和抗原总是有几十纳米大小,因此有必要在几十纳米尺度上检查传感器的传感能力。固定探针,改变检测层厚度,计算结果表明,反射光能量对100纳米厚度的变化非常敏感。这归因于SPP模式的表面模式属性。
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