Potential predictors of the immunotherapy effectiveness

Abstract

The development of novel predictors of immunotherapy efficacy is a clinically important and rapidly developing area. The currently existing predictors (PD-L1, MSI tumor status) do not always guarantee a positive treatment result. In addition, performing these analyses is characterized by the complexity, high cost, and long execution period. Thus, identifying potential new biomarkers in peripheral blood, which would be more accurate and accessible from a technical and economic point of view, is of great interest and is the object of active research. The article is a literature review of the currently available studies written worldwide on the topic of potential markers of the immunotherapy effectiveness. The most interesting and promising studies with intermediate conclusions are presented. We highlighted a number of clinical studies on the use of various assays and platforms for monitoring peripheral immune status. These studies point to the usefulness of these biomarkers as potential prognostic indicators.